1. Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals.

    PNAS 109(30):12147 (2012) PMID 22778419 PMCID PMC3409745

    During Mycobacterium tuberculosis infection, a population of bacteria likely becomes refractory to antibiotic killing in the absence of genotypic resistance, making treatment challenging. We describe an in vitro model capable of yielding a phenotypically antibiotic-tolerant subpopulation of cell...
  2. Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals.

    PNAS 109(30):12147 (2012) PMID 22778419 PMCID PMC3409745

    During Mycobacterium tuberculosis infection, a population of bacteria likely becomes refractory to antibiotic killing in the absence of genotypic resistance, making treatment challenging. We describe an in vitro model capable of yielding a phenotypically antibiotic-tolerant subpopulation of cell...
  3. Phosphoproteomics.

    Wiley Interdisciplinary Reviews: Systems Biolog... 2(3):255 (2010) PMID 20836028

    Current analytical protein methods show phosphorylation to be the most ubiquitous, evolutionary conserved post-translational modification Post-Translational Modification (PTM). The reversible and transient nature of protein phosphorylation allows signal transduction pathways to carry out diverse...