1. Case 11-2015: A 28-Year-Old Woman with Headache, Fever, and a Rash

    New England Journal of Medicine 372(15):1454 (2015) PMID 25853750

    A 28-year-old woman was seen in the emergency department of this hospital because of the acute onset of headache, fever, rash, and myalgias. On examination, she had petechiae on the chest, abdomen, and thighs and a purpuric lesion on the right shoulder. Presentation of Case ...
  2. Ibrutinib in Previously Treated Waldenström’s Macroglobulinemia

    New England Journal of Medicine 372(15):1430 (2015) PMID 25853747

    Background MYD88L265P and CXCR4WHIM mutations are highly prevalent in Waldenström’s macroglobulinemia. MYD88L265P triggers tumor-cell growth through Bruton’s tyrosine kinase, a target of ibrutinib. CXCR4WHIM mutations confer in vitro resistance to ibrutinib.
  3. Ibrutinib in Previously Treated Waldenström’s Macroglobulinemia

    New England Journal of Medicine 372(15):1430 (2015) PMID 25853747

    Background MYD88L265P and CXCR4WHIM mutations are highly prevalent in Waldenström’s macroglobulinemia. MYD88L265P triggers tumor-cell growth through Bruton’s tyrosine kinase, a target of ibrutinib. CXCR4WHIM mutations confer in vitro resistance to ibrutinib.
  4. Ibrutinib in Previously Treated Waldenström’s Macroglobulinemia

    New England Journal of Medicine 372(15):1430 (2015) PMID 25853747

    Background MYD88L265P and CXCR4WHIM mutations are highly prevalent in Waldenström’s macroglobulinemia. MYD88L265P triggers tumor-cell growth through Bruton’s tyrosine kinase, a target of ibrutinib. CXCR4WHIM mutations confer in vitro resistance to ibrutinib.
  5. Ibrutinib in Previously Treated Waldenström’s Macroglobulinemia

    New England Journal of Medicine 372(15):1430 (2015) PMID 25853747

    Background MYD88L265P and CXCR4WHIM mutations are highly prevalent in Waldenström’s macroglobulinemia. MYD88L265P triggers tumor-cell growth through Bruton’s tyrosine kinase, a target of ibrutinib. CXCR4WHIM mutations confer in vitro resistance to ibrutinib.
  6. Chronic lymphocytic leukemia/small lymphocytic lymphoma, version 1.2015.

    Journal of the National Comprehensive Cancer Ne... 13(3):326 (2015) PMID 25736010

    Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are different manifestations of the same disease, which are managed in the same way. The advent of novel monoclonal antibodies (ofatumumab and obinutuzumab) led to the development of effective chemoimmunotherapy regimens. Th...
  7. Chronic lymphocytic leukemia/small lymphocytic lymphoma, version 1.2015.

    Journal of the National Comprehensive Cancer Ne... 13(3):326 (2015) PMID 25736010

    Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are different manifestations of the same disease, which are managed in the same way. The advent of novel monoclonal antibodies (ofatumumab and obinutuzumab) led to the development of effective chemoimmunotherapy regimens. Th...
  8. Case 7-2015: A 25-Year-Old Man with Oral Ulcers, Rash, and Odynophagia

    New England Journal of Medicine 372(9):864 (2015) PMID 25714165

    A 25-year-old man presented with oral ulcers and odynophagia. On examination, there were scattered pink papules and plaques on the trunk, thighs, and buttocks and multiple raised, erythematous nodules on both shins. A diagnostic procedure was performed. Presentation of Case ...
  9. Case 7-2015: A 25-Year-Old Man with Oral Ulcers, Rash, and Odynophagia

    New England Journal of Medicine 372(9):864 (2015)

    A 25-year-old man presented with oral ulcers and odynophagia. On examination, there were scattered pink papules and plaques on the trunk, thighs, and buttocks and multiple raised, erythematous nodules on both shins. A diagnostic procedure was performed. Presentation of Case ...
  10. Case 7-2015: A 25-Year-Old Man with Oral Ulcers, Rash, and Odynophagia

    New England Journal of Medicine 372(9):864 (2015) PMID 25714165

    A 25-year-old man presented with oral ulcers and odynophagia. On examination, there were scattered pink papules and plaques on the trunk, thighs, and buttocks and multiple raised, erythematous nodules on both shins. A diagnostic procedure was performed. Presentation of Case ...
  11. Case 7-2015: A 25-Year-Old Man with Oral Ulcers, Rash, and Odynophagia

    New England Journal of Medicine 372(9):864 (2015) PMID 25714165

    A 25-year-old man presented with oral ulcers and odynophagia. On examination, there were scattered pink papules and plaques on the trunk, thighs, and buttocks and multiple raised, erythematous nodules on both shins. A diagnostic procedure was performed. Presentation of Case ...
  12. Case 6-2015: A 16-Year-Old Boy with Coughing Spells

    New England Journal of Medicine 372(8):765 (2015)

    A 16-year-old boy presented with a 3-week history of cough and nasal congestion and a 3-day history of severe coughing spells, post-tussive emesis, and trouble breathing. A chest radiograph was normal. A diagnostic test was performed. Presentation of Case Dr. Mark A...
  13. Case 5-2015: A 69-Year-Old Woman with Recurrent Skin Lesions after Treatment for Lymphoma

    New England Journal of Medicine 372(7):650 (2015) PMID 25671258

    A 69-year-old woman presented with recurrent skin lesions. Nine months earlier, a diagnosis of anaplastic large-cell lymphoma had been made; systemic chemotherapy was administered, after which new skin lesions appeared. A diagnostic procedure was performed. Presentation of Ca...
  14. Case 4-2015: A 49-Year-Old Man with Obtundation Followed by Agitation and Acidosis

    New England Journal of Medicine 372(5):465 (2015)

    A 49-year-old man was admitted to this hospital after being found unresponsive outdoors; he was next to a half-filled bottle of cloudy liquid with pill fragments. An electrocardiogram showed a QTc interval of 501 msec. A diagnostic test was performed. Presentation of Case ...
  15. Case 4-2015: A 49-Year-Old Man with Obtundation Followed by Agitation and Acidosis

    New England Journal of Medicine 372(5):465 (2015) PMID 25629745

    A 49-year-old man was admitted to this hospital after being found unresponsive outdoors; he was next to a half-filled bottle of cloudy liquid with pill fragments. An electrocardiogram showed a QTc interval of 501 msec. A diagnostic test was performed. Presentation of Case ...
  16. Case 3-2015: A 60-Year-Old Woman with Abdominal Pain, Dyspnea, and Diplopia

    New England Journal of Medicine 372(4):364 (2015) PMID 25607430

    A 60-year-old woman was admitted to the hospital because of abdominal pain, dyspnea, and diplopia. Several hours after presentation, she was unable to phonate clearly or protrude the tongue, and proximal weakness of the arms and legs developed. A diagnostic test was performed. ...
  17. Case 3-2015: A 60-Year-Old Woman with Abdominal Pain, Dyspnea, and Diplopia

    New England Journal of Medicine 372(4):364 (2015) PMID 25607430

    A 60-year-old woman was admitted to the hospital because of abdominal pain, dyspnea, and diplopia. Several hours after presentation, she was unable to phonate clearly or protrude the tongue, and proximal weakness of the arms and legs developed. A diagnostic test was performed. ...
  18. Case 3-2015: A 60-Year-Old Woman with Abdominal Pain, Dyspnea, and Diplopia

    New England Journal of Medicine 372(4):364 (2015) PMID 25607430

    A 60-year-old woman was admitted to the hospital because of abdominal pain, dyspnea, and diplopia. Several hours after presentation, she was unable to phonate clearly or protrude the tongue, and proximal weakness of the arms and legs developed. A diagnostic test was performed. ...
  19. Case 1-2015: A 66-Year-Old Woman with Metastatic Breast Cancer after Endocrine Therapy

    New England Journal of Medicine 372(2):162 (2015) PMID 25564900

    In a 66-year-old woman, enlarged lymph nodes were seen on routine breast imaging. She had received a diagnosis of ductal carcinoma 6 years earlier and had been treated with radiation and chemotherapy, followed by anastrozole. A diagnostic procedure was performed. Presentation...
  20. Case 1-2015: A 66-Year-Old Woman with Metastatic Breast Cancer after Endocrine Therapy

    New England Journal of Medicine 372(2):162 (2015) PMID 25564900

    In a 66-year-old woman, enlarged lymph nodes were seen on routine breast imaging. She had received a diagnosis of ductal carcinoma 6 years earlier and had been treated with radiation and chemotherapy, followed by anastrozole. A diagnostic procedure was performed. Presentation...