1. A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer

    Cell 162(5):1169 (2015)

  2. A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer.

    Cell 162(1):146 (2015) PMID 26140595

    KRAS is one of the most frequently mutated oncogenes in human cancer. Despite substantial efforts, no clinically applicable strategy has yet been developed to effectively treat KRAS-mutant tumors. Here, we perform a cell-line-based screen and identify strong synergistic interactions between cell...
  3. A functional cancer genomics screen identifies a druggable synthetic lethal interaction between MSH3 and PRKDC.

    Cancer Discovery 4(5):592 (2014) PMID 24556366

    Here, we use a large-scale cell line-based approach to identify cancer cell-specific mutations that are associated with DNA-dependent protein kinase catalytic subunit (DNA-PKcs) dependence. For this purpose, we profiled the mutational landscape across 1,319 cancer-associated genes of 67 distinct...
  4. The association between proinflammatory cytokine polymorphisms and cerebral palsy in very preterm infants.

    Cytokine 58(1):57 (2012) PMID 22266275

    Cerebral palsy (CP) is a nonprogressive motor disorder caused by white matter damage in the developing brain and is often accompanied with cognitive and sensory disabilities. The risk of CP is higher among infants born preterm than in more mature infants. Intrauterine infection/inflammation, act...
  5. Posttranscriptional regulation of gene expression-adding another layer of complexity to the DNA damage response.

    Frontiers in Genetics 3:159 (2012) PMID 22936947 PMCID PMC3427493

    In response to DNA damage, cells activate a complex, kinase-based signaling network to arrest the cell cycle and allow time for DNA repair, or, if the extend of damage is beyond repair capacity, induce apoptosis. This signaling network, which is collectively referred to as the DNA damage respons...
  6. Association of MTHFR, MTR, MTRR, RFC1, and DHFR gene polymorphisms with susceptibility to sporadic colon cancer.

    DNA and Cell Biology 30(10):771 (2011) PMID 21438757

    Altered folate levels may play an important role in colon carcinogenesis. The aim of this study was to investigate the association of polymorphisms in key folate-metabolizing genes with susceptibility to sporadic colon cancer. Six common polymorphisms (two in MTHFR and one each in MTR, MTRR, RFC...
  7. IL-2 -330 T/G SNP and serum values-potential new tumor markers in neuroendocrine tumors of the gastrointestinal tract and pancreas (GEP-NETs).

    Klinische Wochenschrift 88(4):423 (2010) PMID 20049409

    Cytokines participate in tumorigenesis of gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Single nucleotide polymorphisms (SNPs) in cytokine genes influence expression of proteins and are evaluated in cancer susceptibility. The aim of this study was to evaluate IL-2 -330 T/G SNP and sus...
  8. Interleukin-6-174 G/C polymorphism is not associated with IL-6 expression and susceptibility to sporadic colon cancer.

    DNA and Cell Biology 29(4):177 (2010) PMID 20132036

    Interleukin-6 (IL-6) has been implicated in tumorigenesis; however, its role is still far from being clearly defined. Regulation of IL-6 expression is highly complex, and additional complexity is introduced by single-nucleotide polymorphisms in the IL-6 gene. These single-nucleotide polymorphism...
  9. Association ofPTPN22C1858T andCTLA-4A49G polymorphisms with type 1 diabetes in Croatians

    Diabetes Research and Clinical Practice 86(3):e54 (2009) PMID 19815302

    In this case–control study the association between the PTPN22 1858T and CTLA-4 49G gene variants and T1D in Croatian population was examined. We found that distribution of PTPN22 C1858T and CTLA-4 A49G genotypes between T1D patient ( n = 102) an...
  10. Association ofPTPN22C1858T andCTLA-4A49G polymorphisms with type 1 diabetes in Croatians

    Diabetes Research and Clinical Practice 86(3):e54 (2009) PMID 19815302

    In this case–control study the association between the PTPN22 1858T and CTLA-4 49G gene variants and T1D in Croatian population was examined. We found that distribution of PTPN22 C1858T and CTLA-4 A49G genotypes between T1D patient ( n = 102) an...
  11. Ethnic differences in the serotonin transporter polymorphism (5-HTTLPR) in several European populations.

    Progress in Neuro-Psychopharmacology and Biolog... 32(7):1735 (2008) PMID 18700161

    The serotonin transporter (5-HTT) is a protein that has a major role in divergent psychiatric disorders, personality traits and behaviors, by regulating serotonergic synaptic function. Transcriptional activity of the 5-HTT gene (5-HTT or SLC6A4) is modulated by a polymorphic repetitive element (...
  12. IL-6-174 C/G polymorphism in the gastroenteropancreatic neuroendocrine tumors (GEP-NETs).

    Experimental and Molecular Pathology 83(3):474 (2007) PMID 17950274

    IL-6 is a pleiotropic cytokine with still controversial role in tumorigenesis of different cancer types. Its promoter SNP-174 C/G is associated with increased IL-6 transcription and in some tumor types with elevated IL-6 serum levels. The role of IL-6 polymorphisms and IL-6 serum values and thei...
  13. IL-6-174 C/Gpolymorphism in the gastroenteropancreatic neuroendocrine tumors (GEP-NETs)

    Experimental and Molecular Pathology 83(3):474 (2007)

    IL-6 is a pleiotropic cytokine with still controversial role in tumorigenesis of different cancer types. Its promoter SNP- 174 C/G is associated with increased IL-6 transcription and in some tumor types with elevated IL-6 serum levels. The role of IL-6 polymorphisms and IL-6 serum val...
  14. Loss of heterozygosity testing using real-time PCR analysis of single nucleotide polymorphisms.

    Journal of Cancer Research and Clinical Oncology 132(3):200 (2006) PMID 16283382

    Colon cancer is a genetic disease, caused by mutations in different oncogenes and tumor-suppressor genes. The aim of this study is to evaluate the usefulness of real-time PCR SNP analysis as a new technique in the loss of heterozygosity (LOH) analysis at the E-cadherin gene locus in sporadic col...