1. Neutralization of colony-stimulating factor 1 receptor prevents sickness behavior syndrome by reprogramming inflammatory monocytes to produce IL-10.

    Brain, Behavior, and Immunity 48:78 (2015) PMID 25749482

    Sickness behavior syndrome (SBS) as characterized by fatigue and depression impairs quality of life in patients with inflammatory diseases caused by infections and autoimmunity. Systemic engagement of CD40 in mice leads to an inflammatory syndrome with acute hepatitis, lymphadenopathy and develo...
  2. Deficiency of the B cell-activating factor receptor results in limited CD169+ macrophage function during viral infection.

    Journal of Virology 89(9):4748 (2015) PMID 25673724 PMCID PMC4403498

    The B cell-activating factor (BAFF) is critical for B cell development and humoral immunity in mice and humans. While the role of BAFF in B cells has been widely described, its role in innate immunity remains unknown. Using BAFF receptor (BAFFR)-deficient mice, we characterized BAFFR-related inn...
  3. Multicenter experience in hematopoietic stem cell transplantation for serious complications of common variable immunodeficiency.

    Journal of Allergy and Clinical Immunology 135(4):988 (2015) PMID 25595268

    Common variable immunodeficiency (CVID) is usually well controlled with immunoglobulin substitution and immunomodulatory drugs. A subgroup of patients has a complicated disease course with high mortality. For these patients, investigation of more invasive, potentially curative treatments, such a...
  4. Influenza vaccine response profiles are affected by vaccine preparation and preexisting immunity, but not HIV infection.

    Human Vaccines & Immunotherapeutics 11(2):391 (2015) PMID 25692740

    Vaccines dramatically reduce infection-related morbidity and mortality. Determining factors that modulate the host response is key to rational vaccine design and demands unsupervised analysis. To longitudinally resolve influenza-specific humoral immune response dynamics we constructed vaccine re...
  5. CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production.

    Nature Communications 6:6217 (2015) PMID 25692415 PMCID PMC4346637

    B cells are essential for antiviral immune defence because they produce neutralizing antibodies, present antigen and maintain the lymphoid architecture. Here we show that intrinsic signalling of CEACAM1 is essential for generating efficient B-cell responses. Although CEACAM1 exerts limited influ...
  6. CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production.

    Nature Communications 6:6217 (2015) PMID 25692415 PMCID PMC4346637

    B cells are essential for antiviral immune defence because they produce neutralizing antibodies, present antigen and maintain the lymphoid architecture. Here we show that intrinsic signalling of CEACAM1 is essential for generating efficient B-cell responses. Although CEACAM1 exerts limited influ...
  7. Exacerbated experimental arthritis in Wiskott-Aldrich syndrome protein deficiency: modulatory role of regulatory B cells.

    European Journal of Immunology 44(9):2692 (2014) PMID 24945741 PMCID PMC4209796

    Patients deficient in the cytoskeletal regulator Wiskott-Aldrich syndrome protein (WASp) are predisposed to varied autoimmunity, suggesting it has an important controlling role in participating cells. IL-10-producing regulatory B (Breg) cells are emerging as important mediators of immunosuppress...
  8. Exacerbated experimental arthritis in Wiskott-Aldrich syndrome protein deficiency: modulatory role of regulatory B cells.

    European Journal of Immunology 44(9):2692 (2014) PMID 24945741 PMCID PMC4209796

    Patients deficient in the cytoskeletal regulator Wiskott-Aldrich syndrome protein (WASp) are predisposed to varied autoimmunity, suggesting it has an important controlling role in participating cells. IL-10-producing regulatory B (Breg) cells are emerging as important mediators of immunosuppress...
  9. Exacerbated experimental arthritis in Wiskott-Aldrich syndrome protein deficiency: modulatory role of regulatory B cells.

    European Journal of Immunology 44(9):2692 (2014) PMID 24945741 PMCID PMC4209796

    Patients deficient in the cytoskeletal regulator Wiskott-Aldrich syndrome protein (WASp) are predisposed to varied autoimmunity, suggesting it has an important controlling role in participating cells. IL-10-producing regulatory B (Breg) cells are emerging as important mediators of immunosuppress...
  10. Genetic variation in schlafen genes in a patient with a recapitulation of the murine Elektra phenotype.

    Journal of Allergy and Clinical Immunology 133(5):1462 (2014) PMID 24373355

  11. Genetic variation in schlafen genes in a patient with a recapitulation of the murine Elektra phenotype

    Journal of Allergy and Clinical Immunology 133(5):1462 (2014)

  12. A common single nucleotide polymorphism impairs B-cell activating factor receptor's multimerization, contributing to common variable immunodeficiency

    Journal of Allergy and Clinical Immunology 133(4):1222 (2014)

  13. A common single nucleotide polymorphism impairs B-cell activating factor receptor's multimerization, contributing to common variable immunodeficiency.

    Journal of Allergy and Clinical Immunology 133(4):1222 (2014) PMID 24406071

  14. A common single nucleotide polymorphism impairs B-cell activating factor receptor's multimerization, contributing to common variable immunodeficiency

    Journal of Allergy and Clinical Immunology 133(4):1222 (2014) PMID 24406071

  15. A common single nucleotide polymorphism impairs B-cell activating factor receptor's multimerization, contributing to common variable immunodeficiency.

    Journal of Allergy and Clinical Immunology 133(4):1222 (2014) PMID 24406071

  16. [Primary and secondary immunodeficiencies].

    Therapeutische Umschau 71(1):31 (2014) PMID 24394207

    Primary Immunodeficiencies (PID) are rare, genetically determined diseases that cause dysfunctional immunity, clinically presenting as susceptibility to infection but also as autoimmunity due to deficient immune tolerance. More than 180 PID have been described to date. To diagnose a PID, seconda...
  17. [Primary and secondary immunodeficiencies].

    Therapeutische Umschau 71(1):31 (2014) PMID 24394207

    Primary Immunodeficiencies (PID) are rare, genetically determined diseases that cause dysfunctional immunity, clinically presenting as susceptibility to infection but also as autoimmunity due to deficient immune tolerance. More than 180 PID have been described to date. To diagnose a PID, seconda...
  18. Usp18 driven enforced viral replication in dendritic cells contributes to break of immunological tolerance in autoimmune diabetes.

    PLoS Pathogens 9(10):e1003650 (2013) PMID 24204252 PMCID PMC3812017

    Infection with viruses carrying cross-reactive antigens is associated with break of immunological tolerance and induction of autoimmune disease. Dendritic cells play an important role in this process. However, it remains unclear why autoimmune-tolerance is broken during virus infection, but usua...
  19. Usp18 driven enforced viral replication in dendritic cells contributes to break of immunological tolerance in autoimmune diabetes.

    PLoS Pathogens 9(10):e1003650 (2013) PMID 24204252 PMCID PMC3812017

    Infection with viruses carrying cross-reactive antigens is associated with break of immunological tolerance and induction of autoimmune disease. Dendritic cells play an important role in this process. However, it remains unclear why autoimmune-tolerance is broken during virus infection, but usua...
  20. A common SNP impairs B cell activating factor receptor's multimerization, contributing to common variable immunodeficiency

    Journal of Allergy and Clinical Immunology (2013)