1. Brain-derived neurotrophic factor is required for axonal growth of selective groups of neurons in the arcuate nucleus.

    Molecular Metabolism 4(6):471 (2015) PMID 26042201 PMCID PMC4443292

    Brain-derived neurotrophic factor (BDNF) is a potent regulator of neuronal development, and the Bdnf gene produces two populations of transcripts with either a short or long 3' untranslated region (3' UTR). Deficiencies in BDNF signaling have been shown to cause severe obesity in humans; however...
  2. The Cellular and Molecular Basis of Direction Selectivity of Aδ-LTMRs

    Cell 160(5):1027 (2015)

  3. The cellular and molecular basis of direction selectivity of Aδ-LTMRs.

    Cell 159(7):1640 (2014) PMID 25525881 PMCID PMC4297767

    The perception of touch, including the direction of stimulus movement across the skin, begins with activation of low-threshold mechanosensory neurons (LTMRs) that innervate the skin. Here, we show that murine Aδ-LTMRs are preferentially tuned to deflection of body hairs in the caudal-to-rostral ...
  4. Sexually dimorphic BDNF signaling directs sensory innervation of the mammary gland.

    Science 338(6112):1357 (2012) PMID 23224557 PMCID PMC3826154

    How neural circuits associated with sexually dimorphic organs are differentially assembled during development is unclear. Here, we report a sexually dimorphic pattern of mouse mammary gland sensory innervation and the mechanism of its formation. Brain-derived neurotrophic factor (BDNF), emanatin...
  5. Sexually dimorphic BDNF signaling directs sensory innervation of the mammary gland.

    Science 338(6112):1357 (2012) PMID 23224557 PMCID PMC3826154

    How neural circuits associated with sexually dimorphic organs are differentially assembled during development is unclear. Here, we report a sexually dimorphic pattern of mouse mammary gland sensory innervation and the mechanism of its formation. Brain-derived neurotrophic factor (BDNF), emanatin...
  6. The functional organization of cutaneous low-threshold mechanosensory neurons.

    Cell 147(7):1615 (2011) PMID 22196735 PMCID PMC3262167

    Innocuous touch of the skin is detected by distinct populations of neurons, the low-threshold mechanoreceptors (LTMRs), which are classified as Aβ-, Aδ-, and C-LTMRs. Here, we report genetic labeling of LTMR subtypes and visualization of their relative patterns of axonal endings in hairy skin an...
  7. The functional organization of cutaneous low-threshold mechanosensory neurons.

    Cell 147(7):1615 (2011) PMID 22196735 PMCID PMC3262167

    Innocuous touch of the skin is detected by distinct populations of neurons, the low-threshold mechanoreceptors (LTMRs), which are classified as Aβ-, Aδ-, and C-LTMRs. Here, we report genetic labeling of LTMR subtypes and visualization of their relative patterns of axonal endings in hairy skin an...
  8. MeCP2: phosphorylated locally, acting globally.

    Neuron 72(1):3 (2011) PMID 21982363

    In this issue of Neuron, Greenberg and colleagues revise our understanding of how activity-dependent MeCP2 phosphorylation regulates distinct aspects of brain development and circuit function. The study also suggests a prominent role for MeCP2 in the regulation of global chromatin state in vivo....
  9. MeCP2: phosphorylated locally, acting globally.

    Neuron 72(1):3 (2011) PMID 21982363

    In this issue of Neuron, Greenberg and colleagues revise our understanding of how activity-dependent MeCP2 phosphorylation regulates distinct aspects of brain development and circuit function. The study also suggests a prominent role for MeCP2 in the regulation of global chromatin state in vivo....
  10. MeCP2: phosphorylated locally, acting globally.

    Neuron 72(1):3 (2011) PMID 21982363

    In this issue of Neuron, Greenberg and colleagues revise our understanding of how activity-dependent MeCP2 phosphorylation regulates distinct aspects of brain development and circuit function. The study also suggests a prominent role for MeCP2 in the regulation of global chromatin state in vivo....
  11. The Functional Organization of Cutaneous Low-Threshold Mechanosensory Neurons

    Cell 147(7):1615 (2011) PMID 22196735 PMCID PMC3262167

    Innocuous touch of the skin is detected by distinct populations of neurons, the low-threshold mechanoreceptors (LTMRs), which are classified as Aβ-, Aδ-, and C-LTMRs. Here, we report genetic labeling of LTMR subtypes and visualization of their relative patterns of axonal endings in hairy sk...
  12. The Functional Organization of Cutaneous Low-Threshold Mechanosensory Neurons

    Cell 147(7):1615 (2011) PMID 22196735 PMCID PMC3262167

    Innocuous touch of the skin is detected by distinct populations of neurons, the low-threshold mechanoreceptors (LTMRs), which are classified as Aβ-, Aδ-, and C-LTMRs. Here, we report genetic labeling of LTMR subtypes and visualization of their relative patterns of axonal endings in hairy sk...
  13. The Functional Organization of Cutaneous Low-Threshold Mechanosensory Neurons

    Cell 147(7):1615 (2011) PMID 22196735 PMCID PMC3262167

    Innocuous touch of the skin is detected by distinct populations of neurons, the low-threshold mechanoreceptors (LTMRs), which are classified as Aβ-, Aδ-, and C-LTMRs. Here, we report genetic labeling of LTMR subtypes and visualization of their relative patterns of axonal endings in hairy sk...
  14. MeCP2: Phosphorylated Locally, Acting Globally

    Neuron 72(1):3 (2011) PMID 21982363

    In this issue of Neuron, Greenberg and colleagues revise our understanding of how activity-dependent MeCP2 phosphorylation regulates distinct aspects of brain development and circuit function. The study also suggests a prominent role for MeCP2 in the regulation of global chromatin st...
  15. MeCP2: Phosphorylated Locally, Acting Globally

    Neuron 72(1):3 (2011)

    In this issue of Neuron, Greenberg and colleagues revise our understanding of how activity-dependent MeCP2 phosphorylation regulates distinct aspects of brain development and circuit function. The study also suggests a prominent role for MeCP2 in the regulation of global chromatin st...
  16. MeCP2: Phosphorylated Locally, Acting Globally

    Neuron 72(1):3 (2011) PMID 21982363

    In this issue of Neuron, Greenberg and colleagues revise our understanding of how activity-dependent MeCP2 phosphorylation regulates distinct aspects of brain development and circuit function. The study also suggests a prominent role for MeCP2 in the regulation of global chromatin st...
  17. Removal of Pax6 partially rescues the loss of ventral structures in Shh null mice.

    Cerebral Cortex 16 Suppl 1:i96 (2006) PMID 16766714

    Pax6 and Gli3 are dorsally expressed genes that are known to antagonize sonic hedgehog (Shh) activity. We have previously shown that dorsoventral patterning defects seen in Shh(-/-) mutants are rescued in Shh(-/-);Gli3(-/-) compound mutants. Here we investigate if the loss of Pax6 can also ameli...
  18. Removal of Pax6 partially rescues the loss of ventral structures in Shh null mice.

    Cerebral Cortex 16 Suppl 1:i96 (2006) PMID 16766714

    Pax6 and Gli3 are dorsally expressed genes that are known to antagonize sonic hedgehog (Shh) activity. We have previously shown that dorsoventral patterning defects seen in Shh(-/-) mutants are rescued in Shh(-/-);Gli3(-/-) compound mutants. Here we investigate if the loss of Pax6 can also ameli...
  19. Combinatorial function of the homeodomain proteins Nkx2.1 and Gsh2 in ventral telencephalic patterning.

    Development 130(20):4895 (2003) PMID 12930780

    Regional patterning of the mammalian telencephalon requires the function of three homeodomain-containing transcription factors, Pax6, Gsh2 and Nkx2.1. These factors are required for the development of the dorsal, lateral and medial domains of the telencephalon, respectively. Previous work has in...
  20. Combinatorial function of the homeodomain proteins Nkx2.1 and Gsh2 in ventral telencephalic patterning.

    Development 130(20):4895 (2003) PMID 12930780

    Regional patterning of the mammalian telencephalon requires the function of three homeodomain-containing transcription factors, Pax6, Gsh2 and Nkx2.1. These factors are required for the development of the dorsal, lateral and medial domains of the telencephalon, respectively. Previous work has in...