1. The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease.

    Cell Metabolism 22(1):100 (2015) PMID 26154056

    A high-fat diet (HFD) induces metabolic disease and low-grade metabolic inflammation in response to changes in the intestinal microbiota through as-yet-unknown mechanisms. Here, we show that a HFD-derived ileum microbiota is responsible for a decrease in Th17 cells of the lamina propria in axeni...
  2. Role of FcγRIIIA (CD16) in IVIg-mediated anti-inflammatory function.

    Journal of Clinical Immunology 34 Suppl 1:S46 (2014) PMID 24728843

    The mechanism for anti-inflammatory action of intravenous immunoglobulin (IVIg) in the treatment of autoimmune and inflammatory diseases involves IgG Fc receptors (FcγR). Although the inhibitory FcγRIIB plays an important role in IVIg action, FcγRIIIA has recently been identified as another majo...
  3. Role of FcγRIIIA (CD16) in IVIg-mediated anti-inflammatory function.

    Journal of Clinical Immunology 34 Suppl 1:S46 (2014) PMID 24728843

    The mechanism for anti-inflammatory action of intravenous immunoglobulin (IVIg) in the treatment of autoimmune and inflammatory diseases involves IgG Fc receptors (FcγR). Although the inhibitory FcγRIIB plays an important role in IVIg action, FcγRIIIA has recently been identified as another majo...
  4. Airway fungal colonization compromises the immune system allowing bacterial pneumonia to prevail.

    Critical Care Medicine 41(9):e191 (2013) PMID 23887232

    To study the correlation between fungal colonization and bacterial pneumonia and to test the effect of antifungal treatments on the development of bacterial pneumonia in colonized rats. Experimental animal investigation. University research laboratory. Pathogen-free male Wistar rats weighing 250...
  5. Airway fungal colonization compromises the immune system allowing bacterial pneumonia to prevail.

    Critical Care Medicine 41(9):e191 (2013) PMID 23887232

    To study the correlation between fungal colonization and bacterial pneumonia and to test the effect of antifungal treatments on the development of bacterial pneumonia in colonized rats. Experimental animal investigation. University research laboratory. Pathogen-free male Wistar rats weighing 250...
  6. Cyclosporine A impairs nucleotide binding oligomerization domain (Nod1)-mediated innate antibacterial renal defenses in mice and human transplant recipients.

    PLoS Pathogens 9(1):e1003152 (2013) PMID 23382681 PMCID PMC3561241

    Acute pyelonephritis (APN), which is mainly caused by uropathogenic Escherichia coli (UPEC), is the most common bacterial complication in renal transplant recipients receiving immunosuppressive treatment. However, it remains unclear how immunosuppressive drugs, such as the calcineurin inhibitor ...
  7. Cyclosporine A impairs nucleotide binding oligomerization domain (Nod1)-mediated innate antibacterial renal defenses in mice and human transplant recipients.

    PLoS Pathogens 9(1):e1003152 (2013) PMID 23382681 PMCID PMC3561241

    Acute pyelonephritis (APN), which is mainly caused by uropathogenic Escherichia coli (UPEC), is the most common bacterial complication in renal transplant recipients receiving immunosuppressive treatment. However, it remains unclear how immunosuppressive drugs, such as the calcineurin inhibitor ...
  8. IgG1 and IVIg induce inhibitory ITAM signaling through FcγRIII controlling inflammatory responses.

    Blood 119(13):3084 (2012) PMID 22337713

    Intravenous immunoglobulin (IVIg) has been used in the treatment of several autoimmune and inflammatory diseases. However, its mechanism of action remains incompletely understood. Here, we investigated the possibility that IVIg induces its anti-inflammatory effects through activating Fcγ recepto...
  9. IgG1 and IVIg induce inhibitory ITAM signaling through FcγRIII controlling inflammatory responses.

    Blood 119(13):3084 (2012) PMID 22337713

    Intravenous immunoglobulin (IVIg) has been used in the treatment of several autoimmune and inflammatory diseases. However, its mechanism of action remains incompletely understood. Here, we investigated the possibility that IVIg induces its anti-inflammatory effects through activating Fcγ recepto...
  10. The interaction between a non-pathogenic and a pathogenic strain synergistically enhances extra-intestinal virulence in Escherichia coli.

    Microbiology 157(Pt 3):774 (2011) PMID 21071495

    Finding two or more genotypes of a single species within an infected sample is a not infrequent event. In this work, three Escherichia coli strains of decreasing extra-intestinal virulence (pathogenic B2S and B1S strains, and the avirulent K-12 MG1655 strain) were tested in septicaemia and urina...
  11. The interaction between a non-pathogenic and a pathogenic strain synergistically enhances extra-intestinal virulence in Escherichia coli.

    Microbiology 157(Pt 3):774 (2011) PMID 21071495

    Finding two or more genotypes of a single species within an infected sample is a not infrequent event. In this work, three Escherichia coli strains of decreasing extra-intestinal virulence (pathogenic B2S and B1S strains, and the avirulent K-12 MG1655 strain) were tested in septicaemia and urina...
  12. Inhibitory ITAM signaling traps activating receptors with the phosphatase SHP-1 to form polarized "inhibisome" clusters.

    Science Signaling 4(169):ra24 (2011) PMID 21505186

    The ability of immunoreceptor tyrosine-based activation motif (ITAM)-bearing receptors to inhibit, rather than activate, signaling by other receptors is a regulatory mechanism of immune homeostasis. However, it remains unclear how inhibitory ITAM (ITAMi) receptor signaling and Src homology 2 (SH...
  13. Inhibitory ITAM signaling traps activating receptors with the phosphatase SHP-1 to form polarized "inhibisome" clusters.

    Science Signaling 4(169):ra24 (2011) PMID 21505186

    The ability of immunoreceptor tyrosine-based activation motif (ITAM)-bearing receptors to inhibit, rather than activate, signaling by other receptors is a regulatory mechanism of immune homeostasis. However, it remains unclear how inhibitory ITAM (ITAMi) receptor signaling and Src homology 2 (SH...
  14. Inhibitory ITAMs: a matter of life and death.

    Trends in Immunology 29(8):366 (2008) PMID 18602341

    The balance between activating and inhibitory signals is essential to control immune responses to microorganisms. Innate and adaptive immune responses are regulated by receptors that signal through either an immunoreceptor tyrosine-based activation motif (ITAM) or an immunoreceptor tyrosine-base...
  15. [Deleterious role of CD16 in sepsis].

    médecine/sciences 24(3):231 (2008) PMID 18334162

  16. [Deleterious role of CD16 in sepsis].

    médecine/sciences 24(3):231 (2008) PMID 18334162

  17. Inhibitory ITAM signaling by Fc alpha RI-FcR gamma chain controls multiple activating responses and prevents renal inflammation.

    Journal of Immunology 180(4):2669 (2008) PMID 18250479

    Inhibitory signaling is an emerging function of ITAM-bearing immunoreceptors in the maintenance of homeostasis. Monovalent targeting of the IgA Fc receptor (FcalphaRI or CD89) by anti-FcalphaRI Fab triggers potent inhibitory ITAM (ITAM(i)) signaling through the associated FcRgamma chain (Fcalpha...
  18. Inhibitory ITAM signaling by Fc alpha RI-FcR gamma chain controls multiple activating responses and prevents renal inflammation.

    Journal of Immunology 180(4):2669 (2008) PMID 18250479

    Inhibitory signaling is an emerging function of ITAM-bearing immunoreceptors in the maintenance of homeostasis. Monovalent targeting of the IgA Fc receptor (FcalphaRI or CD89) by anti-FcalphaRI Fab triggers potent inhibitory ITAM (ITAM(i)) signaling through the associated FcRgamma chain (Fcalpha...
  19. Inhibitory ITAMs: a matter of life and death

    Trends in Immunology 29(8):366 (2008) PMID 18602341

    The balance between activating and inhibitory signals is essential to control immune responses to microorganisms. Innate and adaptive immune responses are regulated by receptors that signal through either an immunoreceptor tyrosine-based activation motif (ITAM) or an immunoreceptor tyrosine...
  20. Inhibitory ITAMs: a matter of life and death

    Trends in Immunology 29(8):366 (2008)

    The balance between activating and inhibitory signals is essential to control immune responses to microorganisms. Innate and adaptive immune responses are regulated by receptors that signal through either an immunoreceptor tyrosine-based activation motif (ITAM) or an immunoreceptor tyrosine...