Electrospun poly(l-lactide)/zein nanofiber mats loaded with Rana chensinensis skin peptides for wound dressing.
Journal of Materials Science: Materials in Medi... 27(9):136 (2016)
Electrospun nanofiber mats can display impressive performance as an ideal wound dressing. In this study, poly(l-lactide)(PLLA)/zein nanofiber mats loaded with Rana chensinensis skin peptides (RCSPs) were successfully produced by two different electrospinning techniques, blend and coaxial, with t...
[Comparative Analysis of Efficacy and Drug Resistance of Imatinib in Patients with Chronic Myeloid Leukemia at Chronic and Advanced Phases].
Zhongguo shi yan xue ye xue za zhi / Zhongguo b... 24(4):1039 (2016)
To compare the efficacy and drug resistance of imatinib in patients with chronic myeloid leukemia (CML) at chronic phase (CP) and advanced phase (accelerated phase and blast crisis (AP+BC).
Forty-two patients with CML were treated with imatinib of different doses(CP 400 mg/d, AP+BC 600 mg/d), an...
Left Ventricular Energy Loss Assessed by Vector Flow Mapping in Patients with Prediabetes and Type 2 Diabetes Mellitus.
Ultrasound in Medicine & Biology 42(8):1730 (2016)
The aim of this study was to assess left ventricular (LV) energy loss (EL) using vector flow mapping in patients with prediabetes (pre-DM) and type 2 diabetes mellitus (DM). Thirty pre-DM patients, 51 DM patients, and 38 controls were studied by transthoracic echocardiography. EL-total, EL-base,...
Rapid determination of bacterial aminoglycoside resistance in environmental samples using membrane electrospray ionization mass spectrometry.
Rapid Communications in Mass Spectrometry 30 Suppl 1:202 (2016)
Antibiotic resistance in pathogenic bacteria is becoming a global public health problem, such as aminoglycoside resistance encoded by the armA gene. Although many methods have been reported, rapid analysis of environmental samples is still challenging.
A rapid analytical method was developed in ...
Molecular evaluation of herbal compounds as potent inhibitors of acetylcholinesterase for the treatment of Alzheimer's disease.
Molecular Medicine Reports 14(1):446 (2016)
Alzheimer's disease (AD) is a progressive disease and the predominant cause of dementia. Common symptoms include short-term memory loss, and confusion with time and place. Individuals with AD depend on their caregivers for assistance, and may pose a burden to them. The acetylcholinesterase (AChE...
Conducting Fibers: Downsized Sheath-Core Conducting Fibers for Weavable Superelastic Wires, Biosensors, Supercapacitors, and Strain Sensors (Adv. Mater. 25/2016).
Advanced Materials (FRG) 28(25):4946 (2016)
Using intelligent textiles for clothing represents one possibility for weavable superelastic conducting fibers that can store energy, sense body motions, and detect biochemicals. On page 4998, S. Yin, R. H. Baughman, and co-workers demonstrate that these hair-like-diameter fibers, comprising buc...
Chymase inhibition protects diabetic rats from renal lesions.
Molecular Medicine Reports 14(1):121 (2016)
The present study aimed to investigate the effects of a chymase inhibitor on renal injury in diabetic rats. A total of 24 Sprague-Dawley rats were randomly divided into the following groups: The control group (n=7), the diabetes group (DM group; n=7), and the DM + chymase inhibitor group (DM + C...
Downsized Sheath-Core Conducting Fibers for Weavable Superelastic Wires, Biosensors, Supercapacitors, and Strain Sensors.
Advanced Materials (FRG) 28(25):4998 (2016)
Hair-like-diameter superelastic conducting fibers, comprising a buckled carbon nanotube sheath on a rubber core, are fabricated, characterized, and deployed as weavable wires, biosensors, supercapacitors, and strain sensors. These downsized sheath-core fibers provide the demonstrated basis for g...
Screening and identification of human ZnT8-specific single-chain variable fragment (scFv) from type 1 diabetes phage display library.
SCIENCE CHINA Life Science 59(7):686 (2016)
Zinc transporter 8 (ZnT8) is a major autoantigen and a predictive marker in type 1 diabetes (T1D). To investigate ZnT8-specific antibodies, a phage display library from T1D was constructed and single-chain antibodies against ZnT8 were screened and identified. Human T1D single-chain variable frag...
Folate-conjugated polyspermine for lung cancer-targeted gene therapy.
Acta Pharmaceutica Sinica B 6(4):336 (2016)
Biodegradable polyamines have long been studied as potential recombinant viral gene vectors. Spermine (SPE) is an endogenous tetra-amine with excellent biocompatibility yet poor gene condensation capacity. We have previously synthesized a polyspermine based on SPE and poly(ethylene glycol) (PEG)...
Mechanism and Selectivity of Ru(II) - and Rh(III) -Catalyzed Oxidative Spiroannulation of Naphthols and Phenols with Alkynes through a C-H Activation/Dearomatization Strategy.
Chemistry: A European Journal 22(27):9356 (2016)
The ruthenium- and rhodium-catalyzed oxidative spiroannulation of naphthols and phenols with alkynes was investigated by means of density functional theory calculations. The results show that the reaction undergoes O-H deprotonation/C(sp(2) )-H bond cleavage through a concerted metalation-deprot...
Polyamine metabolism-based dual functional gene delivery system to synergistically inhibit the proliferation of cancer.
International Journal of Pharmaceutics 506(1-2):79 (2016)
Polyamine content, which is associated with tumor growth, can be regulated by ornithine decarboxylase (ODC) and S-adenosyl methionine decarboxylase (SAMDC), two key enzymes in polyamine biosynthesis. Here we aim to develop a pH-responsive cationic poly(agmatine) based on a polyamine analogue-agm...
Ethyl pyruvate alleviates early brain injury following subarachnoid hemorrhage in rats.
Acta Neurochirurgica 158(6):1069 (2016)
Previous studies have demonstrated the neuroprotective effects of ethyl pyruvate in central nervous system (CNS) diseases. However, whether ethyl pyruvate attenuates early brain injury after subarachnoid hemorrhage (SAH) remains unknown. This study was conducted to investigate the potential effe...
Comparison of Atlantoaxial Rotation and Functional Outcomes of Two Nonfusion Techniques in the Treatment of Anderson-D'Alonzo Type II Odontoid Fractures.
Spine 41(12):E751 (2016)
A retrospective comparative study.
The aim of this study was to compare the outcomes of anterior screw fixation and posterior temporary-fixation in the treatment of Anderson-D'Alonzo type II odontoid fractures.
Posterior C1-C2 temporary-fixation can spare the motion of C1-C2 in the treatment of ...
US-Guided Percutaneous Microwave Ablation for Primary Hyperparathyroidism with Parathyroid Nodules: Feasibility and Safety Study.
Journal of Vascular and Interventional Radiology 27(6):867 (2016)
To test the feasibility, safety, and efficacy of microwave (MW) ablation for primary hyperparathyroidism (pHPT) in patients who are unsuited or unwilling to undergo surgery.
Fifteen patients with benign parathyroid nodules were treated with MW ablation. Ultrasound, laboratory data, and clinical ...
[Sources and Variation Characteristics of Dissolved Lipid Biomarkers in a Typical Karst Underground River].
Environmental Science 37(5):1814 (2016)
Water samples in Qingmuguan underground river were collected to determine the concentration of dissolved lipids, and their sources, composition and migration characteristics in underground river were studied. The results were obtained as follows. (1) The average content of various dissolved lipi...
A new quinoline-based fluorescent probe for Cd(2+) and Hg(2+) with an opposite response in a 100% aqueous environment and live cell imaging.
Dalton Transactions (Print Edition) 45(19):8174 (2016)
A new quinoline-based fluorescent probe was synthesized and characterized. Probe showed opposite fluorescence responses toward Cd(2+) (turn-on) and Hg(2+) (turn-off) in a 100% aqueous environment. X-ray crystallography analysis and TD-DFT calculations showed the different mechanisms of CHEF-base...
Type 2 Diabetes Risk Allele UBE2E2 Is Associated With Decreased Glucose-Stimulated Insulin Release in Elderly Chinese Han Individuals.
Medicine (Baltimore) 95(19):e3604 (2016)
Recently, rs163182 in KCNQ1, rs7612463 in UBE2E2, rs7119 in HMG20A, and rs6815464 in MAEA were discovered as type 2 diabetes (T2D) loci unique to Asians, and rs13342692 in SLC16A11 were newly reported as T2D loci in multiethnicities by genome-wide association (GWA) studies. The aim of the presen...
Doppler Echocardiographic Measurements in Normal Chinese Adults (EMINCA): a prospective, nationwide, and multicentre study.
European Heart Journal - Cardiovascular Imaging 17(5):512 (2016)
Currently, available Doppler echocardiographic reference values are derived mainly from North American and European population studies, which may not applicable to the Chinese population. We aimed to establish normal reference values of Doppler echocardiographic parameters in a nationwide, popul...
Rising prevalence of human papillomavirus-related oropharyngeal cancer in Australia over the last 2 decades.
Head & Neck (Print Edition) 38(5):743 (2016)
This study provides Australian data on the characteristics of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (SCC) over the last 2 decades.
The HPV status of 515 patients with oropharyngeal SCC diagnosed between 1987 and 2010 was determined by HPV E6-targeted multiplex ...