1. Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling.

    Cell 161(5):1101 (2015) PMID 25981665 PMCID PMC4441853

    G-protein-coupled receptors (GPCRs) transduce signals from the extracellular environment to intracellular proteins. To gain structural insight into the regulation of receptor cytoplasmic conformations by extracellular ligands during signaling, we examine the structural dynamics of the cytoplasmi...
  2. Protonation drives the conformational switch in the multidrug transporter LmrP.

    Nature Chemical Biology 10(2):149 (2014) PMID 24316739

    Multidrug antiporters of the major facilitator superfamily couple proton translocation to the extrusion of cytotoxic molecules. The conformational changes that underlie the transport cycle and the structural basis of coupling of these transporters have not been elucidated. Here we used extensive...
  3. Protonation drives the conformational switch in the multidrug transporter LmrP.

    Nature Chemical Biology 10(2):149 (2014) PMID 24316739

    Multidrug antiporters of the major facilitator superfamily couple proton translocation to the extrusion of cytotoxic molecules. The conformational changes that underlie the transport cycle and the structural basis of coupling of these transporters have not been elucidated. Here we used extensive...
  4. Studying the Conformational Cycle of the Secondary Multidrug Transporter LmrP by EPR Spectroscopy

    Biophysical Journal 102(3):660a (2012)

  5. Studying the Conformational Cycle of the Secondary Multidrug Transporter LmrP by EPR Spectroscopy

    Biophysical Journal 102(3):660a (2012)

  6. Interactions between phosphatidylethanolamine headgroup and LmrP, a multidrug transporter: a conserved mechanism for proton gradient sensing?

    Journal of Biological Chemistry 283(14):9369 (2008) PMID 18234676

    In a number of cases, the function of membrane proteins appears to require the presence of specific lipid species in the bilayer. We have shown that the secondary multidrug transporter LmrP requires the presence of phosphatidylethanolamine (PE), as its replacement by phosphatidylcholine (PC) inh...
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  7. Interactions between phosphatidylethanolamine headgroup and LmrP, a multidrug transporter: a conserved mechanism for proton gradient sensing?

    Journal of Biological Chemistry 283(14):9369 (2008) PMID 18234676

    In a number of cases, the function of membrane proteins appears to require the presence of specific lipid species in the bilayer. We have shown that the secondary multidrug transporter LmrP requires the presence of phosphatidylethanolamine (PE), as its replacement by phosphatidylcholine (PC) inh...
    PDF not found