1. Role of immunmodulators in allergen-specific immunotherapy.

    Allergy 66(6):792 (2011) PMID 21332502

    Allergen-specific immunotherapy (SIT) is the only causal treatment of allergic disorders and therefore a cornerstone in the management of respiratory allergy. SIT is effective in patients with allergic rhinitis and mild-to-moderate allergic asthma. Successful treatment is associated with decreas...
  2. Joint influences of Acidic-Mammalian-Chitinase with Interleukin-4 and Toll-like receptor-10 with Interleukin-13 in the genetics of asthma.

    Pediatric Allergy and Immunology 21(4 Pt 2):e679 (2010) PMID 20444155

    In the genetics of asthma, single genetic polymorphisms confer only a small individual risk factor. Haplotype-based association analyses, including joint analyses of several candidate genes, might therefore yield more convincing results than single-region statistics. We set out to test for joint...
  3. Probiotics cannot be generally recommended for primary prevention of atopic dermatitis.

    Journal of Allergy and Clinical Immunology 124(1):170; author reply 170 (2009) PMID 19427684

  4. Probiotics and prevention of allergic disease.

    Current Opinion in Clinical Nutrition and Metab... 12(3):298 (2009) PMID 19318939

    Over the past few decades, public reports have shown increasing enthusiasm for the potential health effects of probiotics. Therefore, the purpose of this review is to focus on studies, which have addressed the use of probiotics for primary prevention of atopic diseases. The Finnish study of Kall...
  5. Association of TNF-alpha with severe respiratory syncytial virus infection and bronchial asthma.

    Pediatric Allergy and Immunology 20(2):157 (2009) PMID 18811622

    Tumor necrosis factor (TNF-)alpha is a proinflammatory cytokine that is important in the innate host defence and thus in the defence of infectious agents. However, in excess it provokes the development of chronic inflammatory diseases. The aim of this study was to test association of TNF with se...
  6. Critical link between TRAIL and CCL20 for the activation of TH2 cells and the expression of allergic airway disease.

    Nature Medicine 13(11):1308 (2007) PMID 17934471

    The role of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in immune responses mediated by T-helper 2 (T(H)2) lymphocytes is unknown. Here we characterize the development of allergic airway disease in TRAIL-deficient (Tnfsf10(-/-)) mice and in mice exposed to short interfering R...
  7. Polymorphisms in the IL 18 gene are associated with specific sensitization to common allergens and allergic rhinitis.

    Journal of Allergy and Clinical Immunology 111(1):117 (2003) PMID 12532106

    Atopy has been linked to chromosome 11q22, a region that harbors the IL18 gene. IL-18 enhances IL-4/IL-13 production and induces IgE production that is directly associated with the pathogenesis of atopic disorders. We sought to investigate whether genetic abnormalities in the regulatory regions ...