1. Inhibition of glutamate regulated calcium entry into leukemic megakaryoblasts reduces cell proliferation and supports differentiation.

    Cellular Signalling 27(9):1860 (2015) PMID 25982509

    Human megakaryocytes release glutamate and express glutamate-gated Ca(2+)-permeable N-methyl-D-aspartate receptors (NMDARs) that support megakaryocytic maturation. While deregulated glutamate pathways impact oncogenicity in some cancers, the role of glutamate and NMDARs in megakaryocytic maligna...
  2. Adipose VEGF Links the White-to-Brown Fat Switch With Environmental, Genetic, and Pharmacological Stimuli in Male Mice.

    Endocrinology 156(6):2059 (2015) PMID 25763639 PMCID PMC4430610

    Living in an enriched environment (EE) decreases adiposity, increases energy expenditure, causes resistance to diet induced obesity, and induces brown-like (beige) cells in white fat via activating a hypothalamic-adipocyte axis. Here we report that EE stimulated vascular endothelial growth facto...
  3. Social overcrowding as a chronic stress model that increases adiposity in mice.

    Psychoneuroendocrinology 51:318 (2015) PMID 25462904

    Stress is a widely recognized risk factor for psychiatric and metabolic disorders. A number of animal models utilizing various stressors have been developed to facilitate our understanding in the pathophysiology of stress-related dysfunctions. The most commonly used chronic stress paradigms incl...
  4. Social overcrowding as a chronic stress model that increases adiposity in mice.

    Psychoneuroendocrinology 51:318 (2015) PMID 25462904

    Stress is a widely recognized risk factor for psychiatric and metabolic disorders. A number of animal models utilizing various stressors have been developed to facilitate our understanding in the pathophysiology of stress-related dysfunctions. The most commonly used chronic stress paradigms incl...
  5. Social overcrowding as a chronic stress model that increases adiposity in mice.

    Psychoneuroendocrinology 51:318 (2015) PMID 25462904 PMCID PMC4273577

    Stress is a widely recognized risk factor for psychiatric and metabolic disorders. A number of animal models utilizing various stressors have been developed to facilitate our understanding in the pathophysiology of stress-related dysfunctions. The most commonly used chronic stress paradigms incl...
  6. Social overcrowding as a chronic stress model that increases adiposity in mice.

    Psychoneuroendocrinology 51:318 (2015) PMID 25462904

    Stress is a widely recognized risk factor for psychiatric and metabolic disorders. A number of animal models utilizing various stressors have been developed to facilitate our understanding in the pathophysiology of stress-related dysfunctions. The most commonly used chronic stress paradigms incl...
  7. Social overcrowding as a chronic stress model that increases adiposity in mice.

    Psychoneuroendocrinology 51:318 (2015) PMID 25462904 PMCID PMC4273577

    Stress is a widely recognized risk factor for psychiatric and metabolic disorders. A number of animal models utilizing various stressors have been developed to facilitate our understanding in the pathophysiology of stress-related dysfunctions. The most commonly used chronic stress paradigms incl...
  8. Network modulation following sham surgery in Parkinson's disease.

    Journal of Clinical Investigation 124(8):3656 (2014) PMID 25036712 PMCID PMC4109544

    Patient responses to placebo and sham effects are a major obstacle to the development of therapies for brain disorders, including Parkinson's disease (PD). Here, we used functional brain imaging and network analysis to study the circuitry underlying placebo effects in PD subjects randomized to s...
  9. Network modulation following sham surgery in Parkinson's disease.

    Journal of Clinical Investigation 124(8):3656 (2014) PMID 25036712 PMCID PMC4109544

    Patient responses to placebo and sham effects are a major obstacle to the development of therapies for brain disorders, including Parkinson's disease (PD). Here, we used functional brain imaging and network analysis to study the circuitry underlying placebo effects in PD subjects randomized to s...
  10. Network modulation following sham surgery in Parkinson's disease.

    Journal of Clinical Investigation 124(8):3656 (2014) PMID 25036712 PMCID PMC4109544

    Patient responses to placebo and sham effects are a major obstacle to the development of therapies for brain disorders, including Parkinson's disease (PD). Here, we used functional brain imaging and network analysis to study the circuitry underlying placebo effects in PD subjects randomized to s...
  11. Regulation of ischemic neuronal death by E2F4-p130 protein complexes.

    Journal of Biological Chemistry 289(26):18202 (2014) PMID 24828495 PMCID PMC4140295

    Inappropriate activation of cell cycle proteins, in particular cyclin D/Cdk4, is implicated in neuronal death induced by various pathologic stresses, including DNA damage and ischemia. Key targets of Cdk4 in proliferating cells include members of the E2F transcription factors, which mediate the ...
  12. Regulation of ischemic neuronal death by E2F4-p130 protein complexes.

    Journal of Biological Chemistry 289(26):18202 (2014) PMID 24828495 PMCID PMC4140295

    Inappropriate activation of cell cycle proteins, in particular cyclin D/Cdk4, is implicated in neuronal death induced by various pathologic stresses, including DNA damage and ischemia. Key targets of Cdk4 in proliferating cells include members of the E2F transcription factors, which mediate the ...
  13. N-methyl-D-aspartate receptors amplify activation and aggregation of human platelets.

    Thrombosis Research 133(5):837 (2014) PMID 24593912

    Glutamate is stored in platelet dense granules and large amounts (>400 μM) are released during thrombus formation. N-methyl-d-aspartate glutamate receptors (NMDARs) have been shown in platelets but their roles are unclear. Platelet activation indices (CD62P expression and PAC-1 binding) and plat...
  14. N-methyl-D-aspartate receptors amplify activation and aggregation of human platelets.

    Thrombosis Research 133(5):837 (2014) PMID 24593912

    Glutamate is stored in platelet dense granules and large amounts (>400 μM) are released during thrombus formation. N-methyl-d-aspartate glutamate receptors (NMDARs) have been shown in platelets but their roles are unclear. Platelet activation indices (CD62P expression and PAC-1 binding) and plat...
  15. Behavior of knock-in mice with a cocaine-insensitive dopamine transporter after virogenetic restoration of cocaine sensitivity in the striatum.

    Neuropharmacology 79:626 (2014) PMID 24412674 PMCID PMC4011184

    Cocaine's main pharmacological actions are the inhibition of the dopamine, serotonin, and norepinephrine transporters. Its main behavioral effects are reward and locomotor stimulation, potentially leading to addiction. Using knock-in mice with a cocaine-insensitive dopamine transporter (DAT-CI m...
  16. Behavior of knock-in mice with a cocaine-insensitive dopamine transporter after virogenetic restoration of cocaine sensitivity in the striatum

    Neuropharmacology 79:626 (2014)

    Cocaine's main pharmacological actions are the inhibition of the dopamine, serotonin, and norepinephrine transporters. Its main behavioral effects are reward and locomotor stimulation, potentially leading to addiction. Using knock-in mice with a cocaine-insensitive dopamine transporter...
  17. Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial.

    The Lancet 383(9923):1129 (2014) PMID 24439297 PMCID PMC4171740

    Choroideremia is an X-linked recessive disease that leads to blindness due to mutations in the CHM gene, which encodes the Rab escort protein 1 (REP1). We assessed the effects of retinal gene therapy with an adeno-associated viral (AAV) vector encoding REP1 (AAV.REP1) in patients with this disea...
  18. Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial.

    The Lancet 383(9923):1129 (2014) PMID 24439297 PMCID PMC4171740

    Choroideremia is an X-linked recessive disease that leads to blindness due to mutations in the CHM gene, which encodes the Rab escort protein 1 (REP1). We assessed the effects of retinal gene therapy with an adeno-associated viral (AAV) vector encoding REP1 (AAV.REP1) in patients with this disea...
  19. Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial.

    The Lancet 383(9923):1129 (2014) PMID 24439297 PMCID PMC4171740

    Choroideremia is an X-linked recessive disease that leads to blindness due to mutations in the CHM gene, which encodes the Rab escort protein 1 (REP1). We assessed the effects of retinal gene therapy with an adeno-associated viral (AAV) vector encoding REP1 (AAV.REP1) in patients with this disea...
  20. Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial.

    The Lancet 383(9923):1129 (2014) PMID 24439297 PMCID PMC4171740

    Choroideremia is an X-linked recessive disease that leads to blindness due to mutations in the CHM gene, which encodes the Rab escort protein 1 (REP1). We assessed the effects of retinal gene therapy with an adeno-associated viral (AAV) vector encoding REP1 (AAV.REP1) in patients with this disea...