1. 13C MR spectroscopy measurements of glutaminase activity in human hepatocellular carcinoma cells using hyperpolarized 13C-labeled glutamine.

    Magnetic Resonance in Medicine 60(2):253 (2008) PMID 18666104

    Dynamic nuclear polarization (DNP) is an emerging technique for increasing the sensitivity of (13)C MR spectroscopy (MRS). [5-(13)C(1)]Glutamine was hyperpolarized using this technique by up to 5%, representing a 6000-fold increase in sensitivity. The conversion of hyperpolarized glutamine to gl...
  2. Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.

    Nature Medicine 13(11):1382 (2007) PMID 17965722

    Measurements of early tumor responses to therapy have been shown, in some cases, to predict treatment outcome. We show in lymphoma-bearing mice injected intravenously with hyperpolarized [1-(13)C]pyruvate that the lactate dehydrogenase-catalyzed flux of (13)C label between the carboxyl groups of...
  3. Metabolic imaging by hyperpolarized 13C magnetic resonance imaging for in vivo tumor diagnosis.

    Cancer Research 66(22):10855 (2006) PMID 17108122

    The "Warburg effect," an elevation in aerobic glycolysis, may be a fundamental property of cancer cells. For cancer diagnosis and treatment, it would be valuable if elevated glycolytic metabolism could be quantified in an image in animals and humans. The pyruvate molecule is at the metabolic cro...