Donor-specific antibodies require preactivated immune system to harm renal transplant.
EBioMedicine 9:366 (2016)
It is an unresolved issue why some kidney transplant recipients with pretransplant donor-specific HLA antibodies (DSA) show a high transplant failure rate, whereas in other patients DSA do not harm the graft. We investigated whether help from preactivated T-cells might be necessary for DSA to ex...
Reporting Quality-of-Life Outcomes in Clinical Trials of Immunosuppressive Therapy in Kidney Transplantation.
American Journal of Kidney Diseases 67(5):722 (2016)
Early conversion from cyclosporine to everolimus following living-donor kidney transplantation: outcomes at 5 years posttransplant in the randomized ZEUS trial.
Clinical Nephrology 85(4):215 (2016)
To assess 5-year efficacy, renal, and safety outcomes following early conversion from cyclosporine to everolimus vs. a standard cyclosporine-based regimen in living-donor kidney transplant (LDKT) recipients.
The ZEUS study was a randomized, open-label, 1-year, multicenter study in which 300 de n...
Overhydration Is a Strong Predictor of Mortality in Peritoneal Dialysis Patients - Independently of Cardiac Failure.
PLoS ONE 11(7):e0158741 (2016)
Overhydration is a common problem in peritoneal dialysis patients and has been shown to be associated with mortality. However, it still remains unclear whether overhydration per se is predictive of mortality or whether it is mainly a reflection of underlying comorbidities. The purpose of our stu...
Intensive Supportive Care plus Immunosuppression in IgA Nephropathy.
New England Journal of Medicine 373(23):2225 (2015)
The outcomes of immunosuppressive therapy, when added to supportive care, in patients with IgA nephropathy are uncertain.
We conducted a multicenter, open-label, randomized, controlled trial with a two-group, parallel, group-sequential design. During a 6-month run-in phase, supportive care (in p...
European Renal Best Practice Guideline on kidney donor and recipient evaluation and perioperative care.
Nephrology Dialysis Transplantation 30(11):1790 (2015)
The European Best Practice Guideline group (EBPG) issued guidelines on the evaluation and selection of kidney donor and kidney transplant candidates, as well as post-transplant recipient care, in the year 2000 and 2002. The new European Renal Best Practice board decided in 2009 that these guidel...
Outcomes Following ABO-Incompatible Kidney Transplantation Performed After Desensitization by Nonantigen-Specific Immunoadsorption.
Transplantation 99(11):2364 (2015)
For desensitization of ABO-incompatible kidney transplant recipients we recently proposed nonantigen-specific immunoadsorption (IA) and rituximab.
We now compared clinical outcomes of 34 ABO-incompatible living-donor kidney recipients who were transplanted using this protocol with that of 68 mat...
Response to A reassessment of the Survival Advantage of Simultaneous Kidney-Pancreas Versus Kidney-Alone Transplantation.
Transplantation 99(11):e175 (2015)
The role of recent thymic emigrant-regulatory T-cell (RTE-Treg) differentiation during pregnancy.
Immunology and Cell Biology 93(10):858 (2015)
During pregnancy, regulatory T cells (Tregs) have a key role in maternal immune tolerance to the semi-allogeneic fetus. Our previous results showed that the naive CD45RA(+)-Treg pool is functionally improved in pregnant women compared with non-pregnant women. Therefore, we examined the thymic ou...
When is contrast-enhanced sonography preferable over conventional ultrasound combined with Doppler imaging in renal transplantation?
Clinical Kidney Journal 8(5):606 (2015)
Conventional ultrasound in combination with colour Doppler imaging is still the standard diagnostic procedure for patients after renal transplantation. However, while conventional ultrasound in combination with Doppler imaging can diagnose renal artery stenosis and vein thrombosis, it is not pos...
Long-Term Follow-Up of Kidney Transplant Recipients With Polycystic Kidney Disease.
Experimental and clinical transplantation : off... 13(5):413 (2015)
Patients with polycystic kidney disease are candidates for kidney transplant. We report the results of our single center study of 250 first transplant recipients with polycystic kidney disease (autosomal dominant [64%], medullary cystic [16%], autosomal recessive [6%], and nonspecified [14%]).
Monitoring of calcineurin inhibitors by NFAT-regulated gene expression in de novo renal allograft recipients on cyclosporine A.
Clinical Nephrology 84(3):165 (2015)
Calcineurin inhibitors are critical-dose drugs with a narrow therapeutic range and optimal monitoring strategies are discussed in terms of safety and efficacy. A new pharmacodynamic monitoring tool - assessing the expression of nuclear factor of activated T-cells (NFAT)-regulated genes - has bee...
Association of Kidney Graft Loss With De Novo Produced Donor-Specific and Non-Donor-Specific HLA Antibodies Detected by Single Antigen Testing.
Transplantation 99(9):1976 (2015)
The association of donor-specific HLA antibodies (DSA) with kidney graft failure has been addressed previously; however, the majority of studies were based on small numbers of patients with graft failure.
We investigated 83 patients with failed kidney transplants for a possible association of de...
Cell therapy for immunosuppression after kidney transplantation.
Deutsche Zeitschrift fÃ¼r Chirurgie 400(5):541 (2015)
To give an overview over cell therapeutic approaches to immunosuppression in clinical kidney transplantation. A focus is on myeloid suppressor cell therapy by mitomycin C-induced cells (MICs).
Literature review with an emphasis on already existing therapies.
Several cell therapeutic approaches t...
Tailoring of alerts substantially reduces the alert burden in computerized clinical decision support for drugs that should be avoided in patients with renal disease.
Journal of the American Medical Informatics Ass... 22(4):881 (2015)
Electronic alerts are often ignored by physicians, which is partly due to the large number of unspecific alerts generated by decision support systems. The aim of the present study was to analyze critical drug prescriptions in a university-based nephrology clinic and to evaluate the effect of dif...
Evolution of allograft fibrosis and function in kidney transplant recipients: a retrospective analysis of stable patients under CNI and mTORi.
Transplant International 28(5):553 (2015)
Histological evaluations of renal allograft biopsies are essential for diagnosis, but still show a low predictive value for long-term allograft function. One limitation relies on the fact that the analysis is usually based on a single biopsy sample, and therefore, no dynamic changes are consider...
Peritoneal ultrafiltration in end-stage chronic heart failure.
Clinical Kidney Journal 8(2):219 (2015)
Cardiorenal syndrome type 2 (CRS-2) is common in end-stage chronic heart failure (CHF). Peritoneal ultrafiltration (pUF) may entail clinical functional improvement and a reduction in hospitalizations.
Thirty-nine consecutive end-stage CHF patients with stable CRS-2 were initiated on ambulatory p...
High interpatient variability in response to mycophenolic acid maintenance therapy in patients with ANCA-associated vasculitis.
Nephrology Dialysis Transplantation 30 Suppl 1:i138 (2015)
Mycophenolic acid (MPA) is used in the maintenance therapy of antineutrophil cytoplasm antibody-associated systemic vasculitis (AASV). MPA exerts its immunosuppression by inhibiting inosine 5'-monophosphate dehydrogenase (IMPDH), depleting activated lymphocytes of guanine nucleotides and retardi...
Psychosocial and physical outcome following kidney donation-a retrospective analysis.
Transplant International 28(4):416 (2015)
Living renal donation is of benefit to the allograft recipient. Careful analysis of the donor outcome is necessary with respect to the medical condition, socioeconomic status, and health-related quality of life. All living kidney donors of the Transplant Center at Heidelberg were included. Renal...
Increased peritoneal damage in glyoxalase 1 knock-down mice treated with peritoneal dialysis.
Nephrology Dialysis Transplantation 30(3):401 (2015)
Peritoneal dialysis (PD) is limited by peritoneal fibrosis and ultrafiltration failure. This is in part caused by the high concentration of glucose degradation products (GDPs) present in PD fluids (PDF) as a consequence of heat sterilization. Existing research in long-term PD has mainly dealt wi...