1. Defined conditions for the isolation and expansion of Basal prostate progenitor cells of mouse and human origin.

    Stem cell reports 4(3):503 (2015) PMID 25702639 PMCID PMC4375832

    Methods to isolate and culture primary prostate epithelial stem/progenitor cells (PESCs) have proven difficult and ineffective. Here, we present a method to grow and expand both murine and human basal PESCs long term in serum- and feeder-free conditions. The method enriches for adherent mouse ba...
  2. Defined conditions for the isolation and expansion of Basal prostate progenitor cells of mouse and human origin.

    Stem cell reports 4(3):503 (2015) PMID 25702639

    Methods to isolate and culture primary prostate epithelial stem/progenitor cells (PESCs) have proven difficult and ineffective. Here, we present a method to grow and expand both murine and human basal PESCs long term in serum- and feeder-free conditions. The method enriches for adherent mouse ba...
  3. Defined conditions for the isolation and expansion of Basal prostate progenitor cells of mouse and human origin.

    Stem cell reports 4(3):503 (2015) PMID 25702639

    Methods to isolate and culture primary prostate epithelial stem/progenitor cells (PESCs) have proven difficult and ineffective. Here, we present a method to grow and expand both murine and human basal PESCs long term in serum- and feeder-free conditions. The method enriches for adherent mouse ba...
  4. Defined conditions for the isolation and expansion of Basal prostate progenitor cells of mouse and human origin.

    Stem cell reports 4(3):503 (2015) PMID 25702639 PMCID PMC4375832

    Methods to isolate and culture primary prostate epithelial stem/progenitor cells (PESCs) have proven difficult and ineffective. Here, we present a method to grow and expand both murine and human basal PESCs long term in serum- and feeder-free conditions. The method enriches for adherent mouse ba...
  5. Defined conditions for the isolation and expansion of Basal prostate progenitor cells of mouse and human origin.

    Stem cell reports 4(3):503 (2015) PMID 25702639 PMCID PMC4375832

    Methods to isolate and culture primary prostate epithelial stem/progenitor cells (PESCs) have proven difficult and ineffective. Here, we present a method to grow and expand both murine and human basal PESCs long term in serum- and feeder-free conditions. The method enriches for adherent mouse ba...
  6. Defined conditions for the isolation and expansion of Basal prostate progenitor cells of mouse and human origin.

    Stem cell reports 4(3):503 (2015) PMID 25702639 PMCID PMC4375832

    Methods to isolate and culture primary prostate epithelial stem/progenitor cells (PESCs) have proven difficult and ineffective. Here, we present a method to grow and expand both murine and human basal PESCs long term in serum- and feeder-free conditions. The method enriches for adherent mouse ba...
  7. Bortezomib sensitizes primary meningioma cells to TRAIL-induced apoptosis by enhancing formation of the death-inducing signaling complex.

    Journal of Neuropathology & Experimental Neurology 73(11):1034 (2014) PMID 25289891

    A meningioma is the most common primary intracranial tumor in adults. Here, we investigated the therapeutic potential of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in 37 meningiomas. Freshly isolated primary meningioma cells were treated with TRAIL with or without differ...
  8. Bortezomib sensitizes primary meningioma cells to TRAIL-induced apoptosis by enhancing formation of the death-inducing signaling complex.

    Journal of Neuropathology & Experimental Neurology 73(11):1034 (2014) PMID 25289891

    A meningioma is the most common primary intracranial tumor in adults. Here, we investigated the therapeutic potential of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in 37 meningiomas. Freshly isolated primary meningioma cells were treated with TRAIL with or without differ...
  9. Expression and prognostic significance of cancer stem cell markers CD24 and CD44 in urothelial bladder cancer xenografts and patients undergoing radical cystectomy.

    Urologic Oncology: Seminars and Original Invest... 32(5):678 (2014) PMID 24631171

    To evaluate CD24/CD44/CD47 cancer stem cell marker expressions in bladder cancer (BCa) and provide data on their prognostic significance for clinical outcome in patients undergoing radical cystectomy (RC). Primary BCa tissue was used for xenograft studies. A tissue microarray was prepared using ...
  10. Expression and prognostic significance of cancer stem cell markers CD24 and CD44 in urothelial bladder cancer xenografts and patients undergoing radical cystectomy.

    Urologic Oncology: Seminars and Original Invest... 32(5):678 (2014) PMID 24631171

    To evaluate CD24/CD44/CD47 cancer stem cell marker expressions in bladder cancer (BCa) and provide data on their prognostic significance for clinical outcome in patients undergoing radical cystectomy (RC). Primary BCa tissue was used for xenograft studies. A tissue microarray was prepared using ...
  11. Expression and prognostic significance of cancer stem cell markers CD24 and CD44 in urothelial bladder cancer xenografts and patients undergoing radical cystectomy.

    Urologic Oncology: Seminars and Original Invest... 32(5):678 (2014) PMID 24631171

    To evaluate CD24/CD44/CD47 cancer stem cell marker expressions in bladder cancer (BCa) and provide data on their prognostic significance for clinical outcome in patients undergoing radical cystectomy (RC). Primary BCa tissue was used for xenograft studies. A tissue microarray was prepared using ...
  12. Expression and prognostic significance of cancer stem cell markers CD24 and CD44 in urothelial bladder cancer xenografts and patients undergoing radical cystectomy.

    Urologic Oncology: Seminars and Original Invest... 32(5):678 (2014) PMID 24631171

    To evaluate CD24/CD44/CD47 cancer stem cell marker expressions in bladder cancer (BCa) and provide data on their prognostic significance for clinical outcome in patients undergoing radical cystectomy (RC). Primary BCa tissue was used for xenograft studies. A tissue microarray was prepared using ...
  13. Development and characteristics of preclinical experimental models for the research of rare neuroendocrine bladder cancer.

    The Journal of Urology 190(6):2263 (2013) PMID 23820058

    For rare cancers such as neuroendocrine bladder cancer treatment options are limited due partly to the lack of preclinical models. Techniques to amplify rare primary neuroendocrine bladder cancer cells could provide novel tools for the discovery of drug and diagnostic targets. We developed precl...
  14. Label retaining cells in cancer--the dormant root of evil?

    Cancer Letters 341(1):73 (2013) PMID 23624300

    The phenomenon of cellular dormancy has been observed in normal adult stem cells in many different tissues such as the skin, the intestine and the hematopoietic system. These dormant cells have been proposed to be important for life-long self-renewal and for the generation of the different cellu...
  15. Label retaining cells in cancer--the dormant root of evil?

    Cancer Letters 341(1):73 (2013) PMID 23624300

    The phenomenon of cellular dormancy has been observed in normal adult stem cells in many different tissues such as the skin, the intestine and the hematopoietic system. These dormant cells have been proposed to be important for life-long self-renewal and for the generation of the different cellu...
  16. Potential role of soluble TRAIL in epithelial injury in children with severe RSV infection.

    American Journal of Respiratory Cell and Molecu... 42(6):697 (2010) PMID 19635930

    Lower respiratory tract infection by respiratory syncytial virus (RSV) is a frequent cause of acute lung injury in young children and infants. Studies in adults and animals suggest that tumor necrosis factor receptor (TNFR) ligands may mediate lung injury by causing apoptosis of epithelial cells...
  17. Oncogenic K-Ras turns death receptors into metastasis-promoting receptors in human and mouse colorectal cancer cells.

    Gastroenterology 138(7):2357 (2010) PMID 20188103

    Death receptors expressed on tumor cells can prevent metastasis formation by inducing apoptosis, but they also can promote migration and invasion. The determinants of death receptor signaling output are poorly defined. Here we investigated the role of oncogenic K-Ras in determining death recepto...
  18. Oncogenic K-Ras turns death receptors into metastasis-promoting receptors in human and mouse colorectal cancer cells.

    Gastroenterology 138(7):2357 (2010) PMID 20188103

    Death receptors expressed on tumor cells can prevent metastasis formation by inducing apoptosis, but they also can promote migration and invasion. The determinants of death receptor signaling output are poorly defined. Here we investigated the role of oncogenic K-Ras in determining death recepto...
  19. Wnt activity defines colon cancer stem cells and is regulated by the microenvironment.

    Nature Cell Biology 12(5):468 (2010) PMID 20418870

    Despite the presence of mutations in APC or beta-catenin, which are believed to activate the Wnt signalling cascade constitutively, most colorectal cancers show cellular heterogeneity when beta-catenin localization is analysed, indicating a more complex regulation of Wnt signalling. We explored ...
  20. The AC133 epitope, but not the CD133 protein, is lost upon cancer stem cell differentiation.

    Cancer Research 70(2):719 (2010) PMID 20068153

    Colon cancer stem cells (CSC) can be identified with AC133, an antibody that detects an epitope on CD133. However, recent evidence suggests that expression of CD133 is not restricted to CSCs, but is also expressed on differentiated tumor cells. Intriguingly, we observed that detection of the AC1...