1. LC-MS/MS based assay and reference intervals in children and adolescents for oxysterols elevated in Niemann-Pick diseases.

    Clinical Biochemistry 48(9):596 (2015) PMID 25819840

    Niemann-Pick type C (NP-C) is a rare progressive neurodegenerative lipid storage disorder with heterogeneous clinical presentation and challenging diagnostic procedures. Recently oxysterols have been reported to be specific biomarkers for NP-C but knowledge on the intra-individual variation and ...
  2. Letter to the Editor

    Gene 558(2):299 (2015)

  3. Letter to the editor.

    Gene 558(2):299 (2015) PMID 25592824

  4. Letter to the Editor

    Gene 558(2):299 (2015) PMID 25592824

  5. ChemR23, the Receptor for Chemerin and Resolvin E1, Is Expressed and Functional on M1 but Not on M2 Macrophages.

    Journal of Immunology 194(5):2330 (2015) PMID 25637017

    ChemR23 is a G protein-coupled receptor that is triggered by two ligands, the peptide chemerin and the eicosapentaenoic acid-derived lipid mediator resolvin E1 (RvE1). Chemerin acts as a chemoattractant for monocytes and macrophages, whereas RvE1 promotes resolution of inflammation-inducing macr...
  6. ChemR23, the Receptor for Chemerin and Resolvin E1, Is Expressed and Functional on M1 but Not on M2 Macrophages.

    Journal of Immunology 194(5):2330 (2015) PMID 25637017

    ChemR23 is a G protein-coupled receptor that is triggered by two ligands, the peptide chemerin and the eicosapentaenoic acid-derived lipid mediator resolvin E1 (RvE1). Chemerin acts as a chemoattractant for monocytes and macrophages, whereas RvE1 promotes resolution of inflammation-inducing macr...
  7. Propofol (Diprivan®) and Intralipid® exacerbate insulin resistance in type-2 diabetic hearts by impairing GLUT4 trafficking.

    Anesthesia & Analgesia 120(2):329 (2015) PMID 25437926

    The IV anesthetic, propofol, when administered as fat emulsion-based formulation (Diprivan) promotes insulin resistance, but the direct effects of propofol and its solvent, Intralipid, on cardiac insulin resistance are unknown. Hearts of healthy and type-2 diabetic rats (generated by fructose fe...
  8. Propofol (Diprivan®) and Intralipid® exacerbate insulin resistance in type-2 diabetic hearts by impairing GLUT4 trafficking.

    Anesthesia & Analgesia 120(2):329 (2015) PMID 25437926

    The IV anesthetic, propofol, when administered as fat emulsion-based formulation (Diprivan) promotes insulin resistance, but the direct effects of propofol and its solvent, Intralipid, on cardiac insulin resistance are unknown. Hearts of healthy and type-2 diabetic rats (generated by fructose fe...
  9. G-protein receptor kinase 4 polymorphism and response to antihypertensive therapy.

    Clinical Chemistry 60(12):1543 (2014) PMID 25301854

    G-protein receptor kinase 4 polymorphism influences blood pressure regulation via modulation of dopamine receptor D1 in renal proximal tubular cells. We investigated the role of G-protein receptor kinase 4 polymorphism in the response to hypertensive therapy in patients with essential hypertensi...
  10. G-protein receptor kinase 4 polymorphism and response to antihypertensive therapy.

    Clinical Chemistry 60(12):1543 (2014) PMID 25301854

    G-protein receptor kinase 4 polymorphism influences blood pressure regulation via modulation of dopamine receptor D1 in renal proximal tubular cells. We investigated the role of G-protein receptor kinase 4 polymorphism in the response to hypertensive therapy in patients with essential hypertensi...
  11. G-protein receptor kinase 4 polymorphism and response to antihypertensive therapy.

    Clinical Chemistry 60(12):1543 (2014) PMID 25301854

    G-protein receptor kinase 4 polymorphism influences blood pressure regulation via modulation of dopamine receptor D1 in renal proximal tubular cells. We investigated the role of G-protein receptor kinase 4 polymorphism in the response to hypertensive therapy in patients with essential hypertensi...
  12. G-protein receptor kinase 4 polymorphism and response to antihypertensive therapy.

    Clinical Chemistry 60(12):1543 (2014) PMID 25301854

    G-protein receptor kinase 4 polymorphism influences blood pressure regulation via modulation of dopamine receptor D1 in renal proximal tubular cells. We investigated the role of G-protein receptor kinase 4 polymorphism in the response to hypertensive therapy in patients with essential hypertensi...
  13. Low dose aspirin is associated with plasma chemerin levels and may reduce adipose tissue inflammation

    Atherosclerosis 235(2):256 (2014)

    Chemerin is a peptide chemoattractant for macrophages and an adipokine regulating adipocyte differentiation and metabolism. Plasma chemerin is increased in chronic inflammatory diseases and in obesity. As inflammation and obesity are risk factors for coronary artery disease (CAD), we i...
  14. Low dose aspirin is associated with plasma chemerin levels and may reduce adipose tissue inflammation.

    Atherosclerosis 235(2):256 (2014) PMID 24880897

    Chemerin is a peptide chemoattractant for macrophages and an adipokine regulating adipocyte differentiation and metabolism. Plasma chemerin is increased in chronic inflammatory diseases and in obesity. As inflammation and obesity are risk factors for coronary artery disease (CAD), we investigate...
  15. Low dose aspirin is associated with plasma chemerin levels and may reduce adipose tissue inflammation

    Atherosclerosis 235(2):256 (2014) PMID 24880897

    Chemerin is a peptide chemoattractant for macrophages and an adipokine regulating adipocyte differentiation and metabolism. Plasma chemerin is increased in chronic inflammatory diseases and in obesity. As inflammation and obesity are risk factors for coronary artery disease (CAD), we i...
  16. Sugar-sweetened beverages with moderate amounts of fructose, but not sucrose, induce Fatty Acid synthesis in healthy young men: a randomized crossover study.

    Journal of Clinical Endocrinology & Metabolism 99(6):2164 (2014) PMID 24601726

    The impact of sugar-sweetened beverages (SSB) on lipid metabolism when consumed in moderate amounts by normal weight subjects is debated. The objective of the study was to investigate the effect of different types of sugars in SSB on fatty acid metabolism (ie, fatty acid synthesis and oxidation)...
  17. Sugar-sweetened beverages with moderate amounts of fructose, but not sucrose, induce Fatty Acid synthesis in healthy young men: a randomized crossover study.

    Journal of Clinical Endocrinology & Metabolism 99(6):2164 (2014) PMID 24601726

    The impact of sugar-sweetened beverages (SSB) on lipid metabolism when consumed in moderate amounts by normal weight subjects is debated. The objective of the study was to investigate the effect of different types of sugars in SSB on fatty acid metabolism (ie, fatty acid synthesis and oxidation)...
  18. Association of polymorphisms in the ALOX15B gene with coronary artery disease.

    Clinical Biochemistry 47(6):349 (2014) PMID 24373925

    Atherosclerosis is a multifactorial disease and the underlying cause of coronary artery disease (CAD), myocardial infarction and stroke. Two main features are involved in the progression of atherosclerosis, lipid retention and inflammation. 12/15-lipoxygenases are involved in inflammation and ha...
  19. Early mitochondrial dysfunction in glycolytic muscle, but not oxidative muscle, of the fructose-fed insulin-resistant rat.

    American Journal of Physiology - Endocrinology ... 306(6):E658 (2014) PMID 24425766 PMCID PMC3948982

    Although evidence that type 2 diabetes mellitus (T2DM) is accompanied by mitochondrial dysfunction in skeletal muscle has been accumulating, a causal link between mitochondrial dysfunction and the pathogenesis of the disease remains unclear. Our study focuses on an early stage of the disease to ...
  20. Early mitochondrial dysfunction in glycolytic muscle, but not oxidative muscle, of the fructose-fed insulin-resistant rat.

    American Journal of Physiology - Endocrinology ... 306(6):E658 (2014) PMID 24425766 PMCID PMC3948982

    Although evidence that type 2 diabetes mellitus (T2DM) is accompanied by mitochondrial dysfunction in skeletal muscle has been accumulating, a causal link between mitochondrial dysfunction and the pathogenesis of the disease remains unclear. Our study focuses on an early stage of the disease to ...