1. The expression and activity of cathepsins D, H and K in asthmatic airways.

    PLoS ONE 8(3):e57245 (2013) PMID 23483898 PMCID PMC3590183

    Tumstatin is an anti-angiogenic collagen IV α3 fragment, levels of which are reduced in the airways of asthmatics. Its reduction may be due to the degradation by extracellular matrix (ECM) proteases. Cathepsins play a role in ECM remodelling, with cathepsin D, H and K (CTSD, CTSH and CTSK) being...
  2. Lamstatin--a novel inhibitor of lymphangiogenesis derived from collagen IV.

    Journal of Cellular and Molecular Medicine 16(12):3062 (2012) PMID 22998238 PMCID PMC4393734

    The lymphatic system is essential for the maintenance of tissue homeostasis and immunity. Its dysfunction in disease (such as lymphangioleiomyomatosis) can lead to chylous effusions, oedema or dissemination of malignant cells. Collagen IV has six α chains, of which some of the non-collagenous-1 ...
  3. Matrikines and the lungs.

    Pharmacology & Therapeutics 134(3):317 (2012) PMID 22366287

    The extracellular matrix is a complex network of fibrous and nonfibrous molecules that not only provide structure to the lung but also interact with and regulate the behaviour of the cells which it surrounds. Recently it has been recognised that components of the extracellular matrix proteins ar...
  4. Haplotypes covering the TNFSF10 gene are associated with bronchial asthma.

    Pediatric Allergy and Immunology 22(1 Pt 1):25 (2011) PMID 20961336

    Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is elevated in the airways of subjects with asthma and has been linked to the development of allergic airway disease by promoting STAT6-dependent T helper 2 cell (T(H) 2) effector functions. To determine whether single nucleotide p...
  5. Reduction of tumstatin in asthmatic airways contributes to angiogenesis, inflammation, and hyperresponsiveness.

    American Journal of Respiratory and Critical Ca... 181(2):106 (2010) PMID 19875687

    Angiogenesis is a prominent feature of remodeling in asthma. Many proangiogenic factors are up-regulated in asthma, but little is known about levels of endogenous antiangiogenic agents. Collagen IV is decreased in the airway basement membrane in asthma. It has six alpha chains, of which the nonc...
  6. Airway vascular reactivity and vascularisation in human chronic airway disease.

    Pulmonary Pharmacology & Therapeutics 22(5):417 (2009) PMID 19409504

    Altered bronchial vascular reactivity and remodelling including angiogenesis are documented features of asthma and other chronic inflammatory airway diseases. Expansion of the bronchial vasculature under these conditions involves both functional (vasodilation, hyperperfusion, increased microvasc...
  7. Association of TNF-alpha with severe respiratory syncytial virus infection and bronchial asthma.

    Pediatric Allergy and Immunology 20(2):157 (2009) PMID 18811622

    Tumor necrosis factor (TNF-)alpha is a proinflammatory cytokine that is important in the innate host defence and thus in the defence of infectious agents. However, in excess it provokes the development of chronic inflammatory diseases. The aim of this study was to test association of TNF with se...
  8. Reconstruction is not renovation - the role of remodeling in asthma.

    Journal of Asthma and Allergy 2:33 (2009) PMID 21437142 PMCID PMC3048608

    The chronicity of asthma results not only in persistent lung inflammation but also in changes in structure and composition of this vital organ. These changes are most commonly referred to as remodeling, and include epithelial dysplasia, angiogenesis, changes in the extracellular matrix and incre...
  9. Interleukin (IL)-18 polymorphism 133C/G is associated with severe respiratory syncytial virus infection.

    Pediatric Infectious Disease Journal 26(12):1094 (2007) PMID 18043444

    Respiratory syncytial virus (RSV) is a major cause of bronchiolitis in infants. During the course of RSV infection, predominant T helper cell (TH) 2 response is associated with disease progression, whereas predominant TH1 reaction provides convalescence. Interleukin (IL)-18 plays an important ro...
  10. Critical link between TRAIL and CCL20 for the activation of TH2 cells and the expression of allergic airway disease.

    Nature Medicine 13(11):1308 (2007) PMID 17934471

    The role of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in immune responses mediated by T-helper 2 (T(H)2) lymphocytes is unknown. Here we characterize the development of allergic airway disease in TRAIL-deficient (Tnfsf10(-/-)) mice and in mice exposed to short interfering R...
  11. Human metapneumovirus induces more severe disease and stronger innate immune response in BALB/c mice as compared with respiratory syncytial virus.

    Respiratory Research 8:6 (2007) PMID 17257445 PMCID PMC1794227

    Human metapneumovirus (HMPV) and respiratory syncytial virus (RSV) are members of the Pneumovirinae subfamily of Paramyxoviridae and can cause severe respiratory disease, especially in infants and young children. Some differences in the clinical course of these infections have been described, bu...