1. Burkholderia pseudomallei type III secretion system cluster 3 ATPase BsaS, a chemotherapeutic target for small-molecule ATPase inhibitors.

    Infection and Immunity 83(4):1276 (2015) PMID 25605762 PMCID PMC4363454

    Melioidosis is an infectious disease of high mortality for humans and other animal species; it is prevalent in tropical regions worldwide. The pathogenesis of melioidosis depends on the ability of its causative agent, the Gram-negative bacterium Burkholderia pseudomallei, to enter and survive in...
  2. Autophagy: Starvation Relieves Transcriptional Repression of ATG Genes

    Current Biology 25(6):R238 (2015) PMID 25784045

    Autophagy is a highly regulated process about which relatively little is known, particularly concerning the transcriptional control of autophagy regulation. A new study identifies a key regulator of the expression of autophagy-related genes, thereby providing insights into the signalli...
  3. A new enabling proteomics methodology to investigate membrane associated proteins from parasitic nematodes: case study using ivermectin resistant and ivermectin susceptible isolates of Caenorhabditis elegans and Haemonchus contortus.

    Veterinary Parasitology 207(3-4):266 (2015) PMID 25537855

    The mechanisms involved in anthelmintic resistance (AR) are complex but a greater understanding of AR management is essential for effective and sustainable control of parasitic helminth worms in livestock. Current tests to measure AR are time consuming and can be technically problematic, gold st...
  4. A new enabling proteomics methodology to investigate membrane associated proteins from parasitic nematodes: case study using ivermectin resistant and ivermectin susceptible isolates of Caenorhabditis elegans and Haemonchus contortus.

    Veterinary Parasitology 207(3-4):266 (2015) PMID 25537855

    The mechanisms involved in anthelmintic resistance (AR) are complex but a greater understanding of AR management is essential for effective and sustainable control of parasitic helminth worms in livestock. Current tests to measure AR are time consuming and can be technically problematic, gold st...
  5. A new enabling proteomics methodology to investigate membrane associated proteins from parasitic nematodes: Case study using ivermectin resistant and ivermectin susceptible isolates of Caenorhabditis elegans and Haemonchus contortus.

    Veterinary Parasitology 207(3-4):266 (2015) PMID 25537855

    The mechanisms involved in anthelmintic resistance (AR) are complex but a greater understanding of AR management is essential for effective and sustainable control of parasitic helminth worms in livestock. Current tests to measure AR are time consuming and can be technically problematic, gold st...
  6. Contributors

  7. Chapter 14 - Opportunities for Implementing the 3 Rs in Drug Development and Safety Assessment Studies Using Nonhuman Primates

    There are many opportunities to benefit science and business through application of the “3 Rs” (replacement, reduction, and refinement) to nonhuman primate use in drug development and safety assessment studies. Scientifically driven approaches that consider individual studies on a case-b...
  8. X-Ray Crystal Structure and Properties of Phanta, a Weakly Fluorescent Photochromic GFP-Like Protein.

    PLoS ONE 10(4):e0123338 (2015) PMID 25923520 PMCID PMC4414407

    Phanta is a reversibly photoswitching chromoprotein (ΦF, 0.003), useful for pcFRET, that was isolated from a mutagenesis screen of the bright green fluorescent eCGP123 (ΦF, 0.8). We have investigated the contribution of substitutions at positions His193, Thr69 and Gln62, individually and in comb...
  9. Proliferation and migration activities of fibroblast growth factor-2 in endothelial cells are modulated by its direct interaction with heparin affin regulatory peptide.

    Biochimie 107 Pt B:350 (2014) PMID 25315978

    Angiogenesis is the physiological process involving the growth of new blood vessels from pre-existing vessels. In normal or pathological angiogenesis, angiogenic growth factors activate cognate receptors on endothelial cells. Fibroblast growth factor-2 (FGF-2) and heparin affin regulatory peptid...
  10. Proliferation and migration activities of fibroblast growth factor-2 in endothelial cells are modulated by its direct interaction with heparin affin regulatory peptide

    Biochimie 107:350 (2014)

    Angiogenesis is the physiological process involving the growth of new blood vessels from pre-existing vessels. In normal or pathological angiogenesis, angiogenic growth factors activate cognate receptors on endothelial cells. Fibroblast growth factor-2 (FGF-2) and heparin affin regulat...
  11. Proliferation and migration activities of fibroblast growth factor-2 in endothelial cells are modulated by its direct interaction with heparin affin regulatory peptide.

    Biochimie 107 Pt B:350 (2014) PMID 25315978

    Angiogenesis is the physiological process involving the growth of new blood vessels from pre-existing vessels. In normal or pathological angiogenesis, angiogenic growth factors activate cognate receptors on endothelial cells. Fibroblast growth factor-2 (FGF-2) and heparin affin regulatory peptid...
  12. You are what you eat.

    Gut Microbes 5(4):541 (2014) PMID 24922547

    Gut bacteria is now considered as an additional host organ, and it has been shown that they have important influences on host developmental and physiological processes. More recently gut bacteria have additionally been implicated in behavioral processes. We showed that in two species of Drosophi...
  13. You are what you eat.

    Gut Microbes 5(4):541 (2014) PMID 24922547

    Gut bacteria is now considered as an additional host organ, and it has been shown that they have important influences on host developmental and physiological processes. More recently gut bacteria have additionally been implicated in behavioral processes. We showed that in two species of Drosophi...
  14. In vitrobiomarker discovery in the parasitic flatwormFasciola hepaticafor monitoring chemotherapeutic treatment

    EuPA open proteomics 3:85 (2014)

  15. The protonophore CCCP interferes with lysosomal degradation of autophagic cargo in yeast and mammalian cells.

    Autophagy 9(11):1862 (2013) PMID 24150213

    Mitophagy is a selective pathway, which targets and delivers mitochondria to the lysosomes for degradation. Depolarization of mitochondria by the protonophore CCCP is a strategy increasingly used to experimentally trigger not only mitophagy, but also bulk autophagy. Using live-cell fluorescence ...
  16. The protonophore CCCP interferes with lysosomal degradation of autophagic cargo in yeast and mammalian cells.

    Autophagy 9(11):1862 (2013) PMID 24150213

    Mitophagy is a selective pathway, which targets and delivers mitochondria to the lysosomes for degradation. Depolarization of mitochondria by the protonophore CCCP is a strategy increasingly used to experimentally trigger not only mitophagy, but also bulk autophagy. Using live-cell fluorescence ...
  17. Autophagy in stem cells.

    Autophagy 9(6):830 (2013) PMID 23486312 PMCID PMC3672294

    Autophagy is a highly conserved cellular process by which cytoplasmic components are sequestered in autophagosomes and delivered to lysosomes for degradation. As a major intracellular degradation and recycling pathway, autophagy is crucial for maintaining cellular homeostasis as well as remodeli...
  18. Autophagy in stem cells.

    Autophagy 9(6):830 (2013) PMID 23486312 PMCID PMC3672294

    Autophagy is a highly conserved cellular process by which cytoplasmic components are sequestered in autophagosomes and delivered to lysosomes for degradation. As a major intracellular degradation and recycling pathway, autophagy is crucial for maintaining cellular homeostasis as well as remodeli...
  19. Autophagy in stem cells.

    Autophagy 9(6):830 (2013) PMID 23486312 PMCID PMC3672294

    Autophagy is a highly conserved cellular process by which cytoplasmic components are sequestered in autophagosomes and delivered to lysosomes for degradation. As a major intracellular degradation and recycling pathway, autophagy is crucial for maintaining cellular homeostasis as well as remodeli...
  20. Autophagy in stem cells.

    Autophagy 9(6):830 (2013) PMID 23486312 PMCID PMC3672294

    Autophagy is a highly conserved cellular process by which cytoplasmic components are sequestered in autophagosomes and delivered to lysosomes for degradation. As a major intracellular degradation and recycling pathway, autophagy is crucial for maintaining cellular homeostasis as well as remodeli...