1. The shaping of genetic variation in edge-of-range populations under past and future climate change.

    Ecology Letters 16(10):1258 (2013) PMID 23890483 PMCID PMC4015367

    With rates of climate change exceeding the rate at which many species are able to shift their range or adapt, it is important to understand how future changes are likely to affect biodiversity at all levels of organisation. Understanding past responses and extent of niche conservatism in climati...
  2. Single primer extension (SPEX) amplification to accurately genotype highly damaged DNA templates

    Forensic Science International: Genetics Supple... 1(1):19 (2008)

    High levels of non-authentic sequence data can be generated by traditional PCR-based methodologies when DNA is damaged, template numbers are small and/or the target amplification size too large. We therefore present an alternate methodology based on single primer extension (SPEX) amplificat...
  3. Statistical evaluation of alternative models of human evolution.

    PNAS 104(45):17614 (2007) PMID 17978179 PMCID PMC2077041

    An appropriate model of recent human evolution is not only important to understand our own history, but it is necessary to disentangle the effects of demography and selection on genome diversity. Although most genetic data support the view that our species originated recently in Africa, it is st...
  4. Novel high-resolution characterization of ancient DNA reveals C > U-type base modification events as the sole cause of post mortem miscoding lesions.

    Nucleic Acids Research 35(17):5717 (2007) PMID 17715147 PMCID PMC2034480

    Ancient DNA (aDNA) research has long depended on the power of PCR to amplify trace amounts of surviving genetic material from preserved specimens. While PCR permits specific loci to be targeted and amplified, in many ways it can be intrinsically unsuited to damaged and degraded aDNA templates. P...
  5. Bayesian estimation of recent migration rates after a spatial expansion.

    Genetics 170(1):409 (2005) PMID 15716508 PMCID PMC1449703

    Approximate Bayesian computation (ABC) is a highly flexible technique that allows the estimation of parameters under demographic models that are too complex to be handled by full-likelihood methods. We assess the utility of this method to estimate the parameters of range expansion in a two-dimen...
  6. Genetic analysis of complex demographic scenarios: spatially expanding populations of the cane toad, Bufo marinus.

    Evolution 58(9):2021 (2004) PMID 15521459

    Inferring the spatial expansion dynamics of invading species from molecular data is notoriously difficult due to the complexity of the processes involved. For these demographic scenarios, genetic data obtained from highly variable markers may be profitably combined with specific sampling schemes...
  7. Population subdivision and molecular sequence variation: theory and analysis of Drosophila ananassae data.

    Genetics 165(3):1385 (2003) PMID 14668389 PMCID PMC1462833

    Population subdivision complicates analysis of molecular variation. Even if neutrality is assumed, three evolutionary forces need to be considered: migration, mutation, and drift. Simplification can be achieved by assuming that the process of migration among and drift within subpopulations is oc...