1. Pathological axonal death through a MAPK cascade that triggers a local energy deficit.

    Cell 160(1-2):161 (2015) PMID 25594179 PMCID PMC4306654

    Axonal death disrupts functional connectivity of neural circuits and is a critical feature of many neurodegenerative disorders. Pathological axon degeneration often occurs independently of known programmed death pathways, but the underlying molecular mechanisms remain largely unknown. Using trau...
  2. Pathological Axonal Death through a MAPK Cascade that Triggers a Local Energy Deficit.

    Cell 160(1-2):161 (2015) PMID 25594179

    Axonal death disrupts functional connectivity of neural circuits and is a critical feature of many neurodegenerative disorders. Pathological axon degeneration often occurs independently of known programmed death pathways, but the underlying molecular mechanisms remain largely unknown. Using trau...
  3. Pathological Axonal Death through a MAPK Cascade that Triggers a Local Energy Deficit.

    Cell 160(1-2):161 (2015) PMID 25594179

    Axonal death disrupts functional connectivity of neural circuits and is a critical feature of many neurodegenerative disorders. Pathological axon degeneration often occurs independently of known programmed death pathways, but the underlying molecular mechanisms remain largely unknown. Using trau...
  4. Pathological Axonal Death through a MAPK Cascade that Triggers a Local Energy Deficit.

    Cell 160(1-2):161 (2015) PMID 25594179 PMCID PMC4306654

    Axonal death disrupts functional connectivity of neural circuits and is a critical feature of many neurodegenerative disorders. Pathological axon degeneration often occurs independently of known programmed death pathways, but the underlying molecular mechanisms remain largely unknown. Using trau...
  5. Gas1 is a receptor for sonic hedgehog to repel enteric axons.

    PNAS 112(1):E73 (2015) PMID 25535338 PMCID PMC4291612

    The myenteric plexus of the enteric nervous system controls the movement of smooth muscles in the gastrointestinal system. They extend their axons between two peripheral smooth muscle layers to form a tubular meshwork arborizing the gut wall. How a tubular axonal meshwork becomes established wit...
  6. Gas1 is a receptor for sonic hedgehog to repel enteric axons.

    PNAS 112(1):E73 (2015) PMID 25535338

    The myenteric plexus of the enteric nervous system controls the movement of smooth muscles in the gastrointestinal system. They extend their axons between two peripheral smooth muscle layers to form a tubular meshwork arborizing the gut wall. How a tubular axonal meshwork becomes established wit...
  7. Gas1 is a receptor for sonic hedgehog to repel enteric axons.

    PNAS 112(1):E73 (2015) PMID 25535338 PMCID PMC4291612

    The myenteric plexus of the enteric nervous system controls the movement of smooth muscles in the gastrointestinal system. They extend their axons between two peripheral smooth muscle layers to form a tubular meshwork arborizing the gut wall. How a tubular axonal meshwork becomes established wit...
  8. Signaling Switch of the Axon Guidance Receptor Robo3 during Vertebrate Evolution.

    Neuron 84(6):1258 (2014) PMID 25433640

    Development of neuronal circuits is controlled by evolutionarily conserved axon guidance molecules, including Slits, the repulsive ligands for roundabout (Robo) receptors, and Netrin-1, which mediates attraction through the DCC receptor. We discovered that the Robo3 receptor fundamentally change...
  9. Signaling switch of the axon guidance receptor Robo3 during vertebrate evolution.

    Neuron 84(6):1258 (2014) PMID 25433640

    Development of neuronal circuits is controlled by evolutionarily conserved axon guidance molecules, including Slits, the repulsive ligands for roundabout (Robo) receptors, and Netrin-1, which mediates attraction through the DCC receptor. We discovered that the Robo3 receptor fundamentally change...
  10. Signaling Switch of the Axon Guidance Receptor Robo3 during Vertebrate Evolution.

    Neuron 84(6):1258 (2014) PMID 25433640

    Development of neuronal circuits is controlled by evolutionarily conserved axon guidance molecules, including Slits, the repulsive ligands for roundabout (Robo) receptors, and Netrin-1, which mediates attraction through the DCC receptor. We discovered that the Robo3 receptor fundamentally change...
  11. Signaling switch of the axon guidance receptor Robo3 during vertebrate evolution.

    Neuron 84(6):1258 (2014) PMID 25433640

    Development of neuronal circuits is controlled by evolutionarily conserved axon guidance molecules, including Slits, the repulsive ligands for roundabout (Robo) receptors, and Netrin-1, which mediates attraction through the DCC receptor. We discovered that the Robo3 receptor fundamentally change...
  12. Signaling switch of the axon guidance receptor Robo3 during vertebrate evolution.

    Neuron 84(6):1258 (2014) PMID 25433640

    Development of neuronal circuits is controlled by evolutionarily conserved axon guidance molecules, including Slits, the repulsive ligands for roundabout (Robo) receptors, and Netrin-1, which mediates attraction through the DCC receptor. We discovered that the Robo3 receptor fundamentally change...
  13. A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.

    Nature Medicine 20(12):1452 (2014) PMID 25419706

    We have identified a rare coding mutation, T835M (rs137875858), in the UNC5C netrin receptor gene that segregated with disease in an autosomal dominant pattern in two families enriched for late-onset Alzheimer's disease and that was associated with disease across four large case-control cohorts ...
  14. A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.

    Nature Medicine 20(12):1452 (2014) PMID 25419706 PMCID PMC4301587

    We have identified a rare coding mutation, T835M (rs137875858), in the UNC5C netrin receptor gene that segregated with disease in an autosomal dominant pattern in two families enriched for late-onset Alzheimer's disease and that was associated with disease across four large case-control cohorts ...
  15. A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.

    Nature Medicine 20(12):1452 (2014) PMID 25419706

    We have identified a rare coding mutation, T835M (rs137875858), in the UNC5C netrin receptor gene that segregated with disease in an autosomal dominant pattern in two families enriched for late-onset Alzheimer's disease and that was associated with disease across four large case-control cohorts ...
  16. A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.

    Nature Medicine 20(12):1452 (2014) PMID 25419706 PMCID PMC4301587

    We have identified a rare coding mutation, T835M (rs137875858), in the UNC5C netrin receptor gene that segregated with disease in an autosomal dominant pattern in two families enriched for late-onset Alzheimer's disease and that was associated with disease across four large case-control cohorts ...
  17. A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.

    Nature Medicine 20(12):1452 (2014) PMID 25419706 PMCID PMC4301587

    We have identified a rare coding mutation, T835M (rs137875858), in the UNC5C netrin receptor gene that segregated with disease in an autosomal dominant pattern in two families enriched for late-onset Alzheimer's disease and that was associated with disease across four large case-control cohorts ...
  18. A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.

    Nature Medicine 20(12):1452 (2014) PMID 25419706 PMCID PMC4301587

    We have identified a rare coding mutation, T835M (rs137875858), in the UNC5C netrin receptor gene that segregated with disease in an autosomal dominant pattern in two families enriched for late-onset Alzheimer's disease and that was associated with disease across four large case-control cohorts ...
  19. iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging.

    Cell 159(4):896 (2014) PMID 25417164

    The visualization of molecularly labeled structures within large intact tissues in three dimensions is an area of intense focus. We describe a simple, rapid, and inexpensive method, iDISCO, that permits whole-mount immunolabeling with volume imaging of large cleared samples ranging from perinata...
  20. iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging.

    Cell 159(4):896 (2014) PMID 25417164

    The visualization of molecularly labeled structures within large intact tissues in three dimensions is an area of intense focus. We describe a simple, rapid, and inexpensive method, iDISCO, that permits whole-mount immunolabeling with volume imaging of large cleared samples ranging from perinata...