1. Inflammation conditions mature dendritic cells to retain the capacity to present new antigens but with altered cytokine secretion function.

    Journal of Immunology 193(8):3851 (2014) PMID 25200952

    Dendritic cells (DCs) are directly activated by pathogen-associated molecular patterns (PAMPs) and undergo maturation. Mature DCs express high levels of MHC class II molecules ("signal 1"), upregulate T cell costimulatory receptors ("signal 2"), and secrete "signal 3" cytokines (e.g., IL-12). Ma...
  2. Inflammation conditions mature dendritic cells to retain the capacity to present new antigens but with altered cytokine secretion function.

    Journal of Immunology 193(8):3851 (2014) PMID 25200952

    Dendritic cells (DCs) are directly activated by pathogen-associated molecular patterns (PAMPs) and undergo maturation. Mature DCs express high levels of MHC class II molecules ("signal 1"), upregulate T cell costimulatory receptors ("signal 2"), and secrete "signal 3" cytokines (e.g., IL-12). Ma...
  3. Inflammation conditions mature dendritic cells to retain the capacity to present new antigens but with altered cytokine secretion function.

    Journal of Immunology 193(8):3851 (2014) PMID 25200952

    Dendritic cells (DCs) are directly activated by pathogen-associated molecular patterns (PAMPs) and undergo maturation. Mature DCs express high levels of MHC class II molecules ("signal 1"), upregulate T cell costimulatory receptors ("signal 2"), and secrete "signal 3" cytokines (e.g., IL-12). Ma...
  4. Blood-stage Plasmodium berghei infection leads to short-lived parasite-associated antigen presentation by dendritic cells.

    European Journal of Immunology 40(6):1674 (2010) PMID 20391433

    Despite extensive evidence that Plasmodium species are capable of stimulating the immune system, the association of malaria with a higher incidence of other infectious diseases and reduced responses to vaccination against unrelated pathogens suggests the existence of immune suppression. Recently...
  5. Blood-stage Plasmodium berghei infection leads to short-lived parasite-associated antigen presentation by dendritic cells.

    European Journal of Immunology 40(6):1674 (2010) PMID 20391433

    Despite extensive evidence that Plasmodium species are capable of stimulating the immune system, the association of malaria with a higher incidence of other infectious diseases and reduced responses to vaccination against unrelated pathogens suggests the existence of immune suppression. Recently...
  6. Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells.

    Nature Immunology 9(11):1244 (2008) PMID 18849989

    The importance of conventional dendritic cells (cDCs) in the processing and presentation of antigen is well established, but the contribution of plasmacytoid dendritic cells (pDCs) to these processes, and hence to T cell immunity, remains unclear. Here we showed that unlike cDCs, pDCs continued ...
  7. Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells.

    Nature Immunology 9(11):1244 (2008) PMID 18849989

    The importance of conventional dendritic cells (cDCs) in the processing and presentation of antigen is well established, but the contribution of plasmacytoid dendritic cells (pDCs) to these processes, and hence to T cell immunity, remains unclear. Here we showed that unlike cDCs, pDCs continued ...
  8. Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling.

    Immunology and Cell Biology 86(2):200 (2008) PMID 18026177

    Dendritic cells (DCs) play major roles in immunosurveillance. In peripheral tissues, 'immature' DCs are dedicated to capturing antigens. Detection of pathogens through Toll-like receptors (TLRs) triggers DC migration to the lymph nodes (LNs), where they acquire a 'mature' phenotype specialized a...
  9. Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling.

    Immunology and Cell Biology 86(2):200 (2008) PMID 18026177

    Dendritic cells (DCs) play major roles in immunosurveillance. In peripheral tissues, 'immature' DCs are dedicated to capturing antigens. Detection of pathogens through Toll-like receptors (TLRs) triggers DC migration to the lymph nodes (LNs), where they acquire a 'mature' phenotype specialized a...
  10. Dendritic cell preactivation impairs MHC class II presentation of vaccines and endogenous viral antigens.

    PNAS 104(45):17753 (2007) PMID 17978177 PMCID PMC2077019

    When dendritic cells (DCs) encounter signals associated with infection or inflammation, they become activated and undergo maturation. Mature DCs are very efficient at presenting antigens captured in association with their activating signal but fail to present subsequently encountered antigens, a...
  11. Dendritic cell preactivation impairs MHC class II presentation of vaccines and endogenous viral antigens.

    PNAS 104(45):17753 (2007) PMID 17978177 PMCID PMC2077019

    When dendritic cells (DCs) encounter signals associated with infection or inflammation, they become activated and undergo maturation. Mature DCs are very efficient at presenting antigens captured in association with their activating signal but fail to present subsequently encountered antigens, a...