MLL-SEPT5 Fusion Transcript in Two de novo Acute Myeloid Leukemia Patients With t(11;22)(q23;q11).
Annals of laboratory medicine 36(5):501 (2016)
Plasmon resonance energy transfer and plexcitonic solar cell.
Nanoscale 8(32):15071 (2016)
Plasmon-mediated energy transfer is highly desirable in photo-electronic nanodevices, but the direct injection efficiency of "hot electrons" in plasmonic photo-detectors and plasmon-sensitized solar cells (plasmon-SSCs) is poor. On another front, Fano resonance induced by strong plasmon-exciton ...
Efficient Targeting of Adipose Tissue Macrophages in Obesity with Polysaccharide Nanocarriers.
ACS Nano 10(7):6952 (2016)
Obesity leads to an increased risk for type 2 diabetes, heart disease, stroke, and cancer. The causal link between obesity and these pathologies has recently been identified as chronic low-grade systemic inflammation initiated by pro-inflammatory macrophages in visceral adipose tissue. Current m...
Synthesis, Activity, and Docking Study of Novel Phenylthiazole-Carboxamido Acid Derivatives as FFA2 Agonists.
Chemical Biology & Drug Design 88(1):26 (2016)
Free fatty acid receptor 2 (FFA2), also known as GPR43, is activated by short-chain fatty acids (SCFAs) that are mainly produced by the gut microbiota through the fermentation of undigested carbohydrates and dietary fibers. FFA2 currently appears to be a potential target in the management of obe...
Design, Synthesis, and Evaluation of in Vitro and in Vivo Anticancer Activity of 4-Substituted Coumarins: A Novel Class of Potent Tubulin Polymerization Inhibitors.
Journal of medicinal and pharmaceutical chemistry 59(12):5721 (2016)
In this paper, a series of novel 4-substituted coumarin derivatives were synthesized. Among these compounds 34, 39, 40, 43, 62, 65, and 67 exhibited significant antiproliferative activity toward a panel of tumor cell lines at subnanomolar IC50 values. Compound 65 showed potent antiproliferative ...
A Cu-catalyzed four-component cascade reaction to construct β-ester-γ-amino ketones.
Organic & Biomolecular Chemistry 14(23):5310 (2016)
Herein, a novel Cu-catalyzed four-component cascade reaction, which encompasses styrenes, diazo compounds, amines, and tert-butyl hydroperoxide (TBHP), was developed for the synthesis of β-ester-γ-amino ketones. Mechanistically, this transformation was initiated by the interception of an electro...
Growth of metal-semiconductor core-multishell nanorods with optimized field confinement and nonlinear enhancement.
Nanoscale 8(23):11969 (2016)
This paper describes a facile method for the synthesis of Au/AuAg/Ag2S/PbS core-multishell nanorods with double trapping layers. The synthesis, in sequence, involved deposition of Ag shells onto the surfaces of Au nanorod seeds, formation of AuAg shells by a galvanic replacement reaction, and ov...
The Successful Complete Remission Induction by Sorafenib Monotherapy in a FLT3-D835Y-Positive Patient with Refractory Acute Monocytic Leukemia.
Indian Journal of Hematology and Blood Transfusion 32(Suppl 1):38 (2016)
Sorafenib has been shown to be active in AML patients with FLT3-ITD. However, the effect of sorafenib in AML patients with FLT-TKD has never been well determined. Moreover, acquisition of secondary FLT3 TKD mutations, mainly at D835 (D835F/H/V/Y), are recognized as the major mechanisms of resist...
Polyoxypregnane steroids with an open-chain sugar moiety from Marsdenia tenacissima and their chemoresistance reversal activity.
Phytochemistry 126:47 (2016)
A polyoxypregnane aglycone, 12β-O-acetyl-11α-O-isobutyryltenacigenin B, and four polyoxypregnane glycosides with a pachybionic acid ester moiety, 12β-O-acetyl-3-O-(6-deoxy-3-O-methyl-β-D-allopyranosyl-(1→4)-β-D-oleandronyl)-11α-O-isobutyryltenacigenin B, 12β-O-acetyl-3-O-(6-deoxy-3-O-methyl-β-D-...
Laparoscopic colonic anastomosis using a degradable stent in a porcine model.
World Journal of Gastroenterology 22(19):4707 (2016)
To explore the feasibility and safety of laparoscopic colonic anastomosis using a degradable stent in a porcine model.
Twenty Bama mini-pigs were randomly assigned to a stent group (n = 10) and control group (hand-sewn anastomosis, n = 10). The anastomotic completion and operation times were rec...
Antiviral therapy for hepatitis B virus-related hepatocellular carcinoma after surgery: A comment for moving forward.
World Journal of Hepatology 8(13):605 (2016)
Recurrence rate of hepatocellular carcinoma remains quite high even after surgery, and no postoperative therapies have been definitively shown to prevent hepatocellular carcinoma recurrence. A previous study showed that therapy with nucleos(t)ide analogues given to such patients after surgery si...
Prognostic value of FGF23 among patients with end-stage renal disease: a systematic review and meta-analysis.
Biomarkers in Medicine 10(5):547 (2016)
Prognostic value of FGF23 in end-stage renal disease (ESRD) patients is controversial. A systematic review was conducted to quantify the association between elevated FGF23 and overall mortality among ESRD patients.
MEDLINE, EMBASE, PubMed and reference lists were searched. Quality of the include...
Synthesis, in vitro and in vivo evaluation of novel substituted N-(4-(2-(4-benzylpiperazin-1-yl)ethoxy)phenyl)-N-methyl-quinazolin-4-amines as potent antitumor agents.
Bioorganic & Medicinal Chemistry Letters 26(8):1931 (2016)
A novel series of substituted N-(4-(2-(4-benzylpiperazin-1-yl)ethoxy)phenyl)-N-methylquinazolin-4-amines were synthesized and evaluated for their in vitro antiproliferative activity. Among them, compound 7a exhibited the best potency, with IC50 values of 0.029-0.147 μM against four types of canc...
Nrf2 plays a pivotal role in protection against burn trauma-induced intestinal injury and death.
Oncotarget 7(15):19272 (2016)
Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a basic leucine zipper transcription factor that principally defends against oxidative stress and also plays a unique role in severe sepsis. However, its contribution to intestinal injury and death after burn trauma is unclear.In this study, ...
Comprehensive treatments for hepatocellular carcinoma with tumor thrombus in major portal vein.
World Journal of Gastroenterology 22(13):3632 (2016)
To evaluate the efficacy of transcatheter arterial chemoembolisation (TACE) compared with surgical intervention and sorafenib for treatment of hepatocellular carcinoma (HCC) in patients with tumor thrombus extending to the main portal vein.
From 2009 to 2013, a total of 418 HCC patients with tum...
miR-17-92 plays an oncogenic role and conveys chemo-resistance to cisplatin in human prostate cancer cells.
International Journal of Oncology 48(4):1737 (2016)
The mir-17-92 cluster consists of six mature miRNAs and is implicated in diverse human cancers by targeting mRNAs involved in distinct pathways that either promote or inhibit carcinogenesis. However, the molecular mechanism underlying the mir-17-92 cluster-mediated pro-tumorigenic or anti-tumori...
Protective role of nuclear factor erythroid 2-related factor 2 in the hemorrhagic shock-induced inflammatory response.
International Journal of Molecular Medicine 37(4):1014 (2016)
Hemorrhagic shock (HS) following trauma or major surgery significantly contributes to mortality. However, the mechanisms through which HS activates the inflammatory response are not yet fully understood. Nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2), a bZIP transcription factor,...
[Application of High-throughput Sequencing in Acute Myeloid Leukemia Patients with Positive FLT3-ITD].
Zhongguo shi yan xue ye xue za zhi / Zhongguo b... 24(2):381 (2016)
OBJECTICE: To evaluate the application of high-throughput sequencing to sequence the FMS-like Tyrosine Kinase 3 internal tandem duplication (FLT3-ITD) in de novo acute myeloid leukemia (AML) patients with lower allelic ratio FLT3-ITD mutation or more than one ITD, and to analyze the feature of I...
Cell Autonomous and Nonautonomous Function of CUL4B in Mouse Spermatogenesis.
Journal of Biological Chemistry 291(13):6923 (2016)
CUL4B ubiquitin ligase belongs to the cullin-RING ubiquitin ligase family. Although sharing many sequence and structural similarities, CUL4B plays distinct roles in spermatogenesis from its homologous protein CUL4A. We previously reported that genetic ablation ofCul4ain mice led to male infertil...
Multidentate Polymer Coatings for Compact and Homogeneous Quantum Dots with Efficient Bioconjugation.
Journal of the American Chemical Society 138(10):3382 (2016)
Quantum dots are fluorescent nanoparticles used to detect and image proteins and nucleic acids. Compared with organic dyes and fluorescent proteins, these nanocrystals have enhanced brightness, photostability, and wavelength tunability, but their larger size limits their use. Recently, multident...