1. Production and Partial Purification of Tannase from Aspergillus ficuum Gim 3.6.

    Preparative Biochemistry and Biotechnology 45(8):754 (2015) PMID 25126886

    A novel fungal strain, Aspergillus ficuum Gim 3.6, was evaluated for its tannase-producing capability in a wheat bran-based solid-state fermentation. Thin-layer chromatography (TLC) analysis revealed that the strain was able to degrade tannic acid to gallic acid and pyrogallol during the ferment...
  2. Identification of a novel mutation of the COL2A1 gene in a Chinese family with spondyloepiphyseal dysplasia congenita.

    European Spine Journal 24(8):1813 (2015) PMID 25967556

    To identify potential disease-causing mutation in the COL2A1 gene in a Chinese family with autosomal dominant spondyloepiphyseal dysplasia congenita (SEDC) and to analyze the phenotype-genotype correlation. Complete physical and radiographic examinations of four affected individuals from SEDC fa...
  3. Efficacy of Mitral Valve Repair as an Adjunct Procedure to Coronary Artery Bypass Grafting in Moderate Ischemic Mitral Regurgitation: A Meta-Analysis of Randomized Trials.

    Journal Of Cardiac Surgery 30(8):623 (2015) PMID 26081462

    Whether moderate ischemic mitral regurgitation (IMR) should be repaired during coronary artery bypass grafting (CABG) is still uncertain. This meta-analysis of randomized controlled trials (RCTs) evaluated the efficacy of adding mitral valve repair (MVR) to CABG in patients with moderate IMR. We...
  4. Coaxial nozzle-assisted 3D bioprinting with built-in microchannels for nutrients delivery.

    Biomaterials 61:203 (2015) PMID 26004235

    This study offers a novel 3D bioprinting method based on hollow calcium alginate filaments by using a coaxial nozzle, in which high strength cell-laden hydrogel 3D structures with built-in microchannels can be fabricated by controlling the crosslinking time to realize fusion of adjacent hollow f...
  5. Synthesis and biological evaluation of diarylthiazole derivatives as antimitotic and antivascular agents with potent antitumor activity.

    Bioorganic & Medicinal Chemistry 23(13):3337 (2015) PMID 25937236

    By switching position of the N and S atom in the thiazole ring which were similar to the previously reported agent 5-(4-ethoxyphenyl)-4-(3',4',5'-trimethoxyphenyl)thiazol-2-amine, a series of 4,5-diarylthiazole derivatives were synthesized using Friedel-Crafts reaction based on chemical modifica...
  6. Quantification of patulin in fruit leathers by ultra-high-performance liquid chromatography-photodiode array (UPLC-PDA).

    Food Additives & Contaminants: Part A - Chemist... 32(7):1164 (2015) PMID 25832782

    Patulin is a mycotoxin commonly found in certain fruit and fruit products. For this reason many countries have established regulatory limits pertaining to, in particular, apple juice and apple products. Fruit leathers are produced by dehydrating fruit puree, leaving a sweet product that has a le...
  7. Discovery of a Potent 9-Deazaxanthine-based Agent for the Treatment of Obesity-Related Non-alcoholic Fatty Liver Disease.

    Chemical Biology & Drug Design 86(1):846 (2015) PMID 25215862

    A series of deazaxanthine-based derivatives were rationally prepared and evaluated. 8g exhibited the most potent glucose-lowering effect on HepG2 cell line and modulated adiponectin and leptin expression in 3T3-L1 adipocytes. Oral administration of 8g at 25 mg/kg/day for 4 weeks manifested thera...
  8. A novel molecular beacon-based method for isothermal detection of sequence-specific DNA via T7 RNA polymerase-aided target regeneration.

    Biosensors and Bioelectronics 68:365 (2015) PMID 25613814

    Developing molecular beacon (MB)-based method for DNA detection has been of great interest to many researchers because of its intrinsic advantages of simplicity, rapidity, and specificity. In this work, we have developed a novel MB-based method for isothermal detection of sequence-specific DNA v...
  9. Synthesis and biological evaluation of novel pyrazoline derivatives as potent anti-inflammatory agents.

    Bioorganic & Medicinal Chemistry Letters 25(11):2429 (2015) PMID 25881822

    Twenty-eight pyrazoline derivatives, which originated from pyranochalcones, have been synthesized and evaluated for their inhibitory potency on the production of inflammatory mediator nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. Among them, three compounds (1c, 11c, and 15c) exhibited po...
  10. Platinum multicubes prepared by ni(2+) -mediated shape evolution exhibit high electrocatalytic activity for oxygen reduction.

    Angewandte Chemie. International edition in Eng... 54(19):5666 (2015) PMID 25756931

    Pt(100) facets are generally considered less active for the oxygen reduction reaction (ORR). Reported herein is a unique Pt-branched structure, a multicube, whose surface is mostly enclosed by {100} facets but contains high-index facets at the small junction area between the adjacent cubic compo...
  11. Intermediate-stage HCC--upfront resection can be feasible.

    Nature Reviews Clinical Oncology 12(5) (2015) PMID 25850549

  12. Effect of preoperative angiotensin-converting enzyme inhibitor on the outcome of coronary artery bypass graft surgery.

    European Journal of Cardio-thoracic Surgery 47(5):788 (2015) PMID 25079771

    The safety of the preoperative administration of angiotensin-converting enzyme inhibitors (ACEIs) in patients undergoing coronary artery bypass grafting (CABG) surgery is still uncertain. This systematic review thus evaluated the effect of preoperative ACEIs on the clinical outcomes in patients ...
  13. Scaffold-based design of xanthine as highly potent inhibitors of DPP-IV for improving glucose homeostasis in DIO mice.

    Molecular Diversity 19(2):333 (2015) PMID 25672287

    Diabetes mellitus, commonly characterized by hyperglycemia, is a group of metabolic diseases. Some oral anti-diabetic drugs show poor tolerability during chronic treatment, and associate with undesired side effects. Recent advances in the understanding of physiological functions of incretins and...
  14. 7-glutathione pyrrole adduct: a potential DNA reactive metabolite of pyrrolizidine alkaloids.

    Chemical Research in Toxicology 28(4):615 (2015) PMID 25768656

    Pyrrolizidine alkaloid (PA)-containing plants are the most common poisonous plants affecting livestock, wildlife, and humans. PAs require metabolic activation to form pyrrolic metabolites to exert cytotoxicity and tumorigenicity. We previously determined that metabolism of tumorigenic PAs produc...
  15. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis.

    Cell 161(2):264 (2015) PMID 25860609 PMCID PMC4393509

    The gastrointestinal (GI) tract contains much of the body's serotonin (5-hydroxytryptamine, 5-HT), but mechanisms controlling the metabolism of gut-derived 5-HT remain unclear. Here, we demonstrate that the microbiota plays a critical role in regulating host 5-HT. Indigenous spore-forming bacter...
  16. Modified iron-carbon as heterogeneous electro-Fenton catalyst for organic pollutant degradation in near neutral pH condition: Characterization, degradation activity and stability

    Electrochimica Acta 160:254 (2015)

    Polytetrafluoroethylene (PTFE) was firstly used to modify the surface characteristics of Fe-C particles and acted as catalyst to degrade 2,4-dichlorophenol (2,4-DCP) by heterogeneous electro-Fenton (EF) in near neutral pH condition. Fe-C particles before and after PTFE modification, an...
  17. Modified iron-carbon as heterogeneous electro-Fenton catalyst for organic pollutant degradation in near neutral pH condition: Characterization, degradation activity and stability

    Electrochimica Acta 160:254 (2015)

    Polytetrafluoroethylene (PTFE) was firstly used to modify the surface characteristics of Fe-C particles and acted as catalyst to degrade 2,4-dichlorophenol (2,4-DCP) by heterogeneous electro-Fenton (EF) in near neutral pH condition. Fe-C particles before and after PTFE modification, an...
  18. Construction of an immobilised acetylcholinesterase column and its application in screening insecticidal constituents from Magnolia officinalis.

    Pest Management Science 71(4):607 (2015) PMID 25228142

    Application of a matrix-immobilised target enzyme for screening inhibitors is widely used in drug development, but there are few studies in insecticide discovery. In this paper, an economical and effective immobilised acetylcholinesterase (AChE) column was prepared using the sol-gel embedment me...
  19. [Identification of a novel mutation of COL2A1 gene in a Chinese family affected with spondyloepiphyseal dysplasia congenita].

    Zhonghua yi xue yi chuan xue za zhi = Zhonghua ... 32(2):240 (2015) PMID 25863096

    To identify potential disease-causing mutation in the COL2A1 gene in a Chinese family affected with autosomal dominant spondyloepiphyseal dysplasia congenita (SEDC; OMIM 183900) and to analyze the phenotype-genotype correlation. Complete physical, and radiographic examinations of 4 affected indi...
  20. Structural exploration, synthesis and pharmacological evaluation of novel 5-benzylidenethiazolidine-2,4-dione derivatives as iNOS inhibitors against inflammatory diseases.

    European Journal of Medicinal Chemistry 92:178 (2015) PMID 25555141

    In our previous work, 3I inhibited the LPS-induced iNOS activity and NO production in RAW 264.7 cells and improved joint inflammation and cartilage destruction in inflammatory model. In this study, we synthesized 59 derivatives and bioisosteres on the basis of 3I by Knoevenagel condensation and ...