Reduction of polyethylenimine-coated iron oxide nanoparticles induced autophagy and cytotoxicity by lactosylation.
Regenerative biomaterials 3(4):223 (2016)
Superparamagnetic iron oxide (SPIO) nanoparticles are excellent magnetic resonance contrast agents and surface engineering can expand their applications. When covered with amphiphilic alkyl-polyethyleneimine (PEI), the modified SPIO nanoparticles can be used as MRI visible gene/drug delivery car...
Leptin suppresses adenosine triphosphate-induced impairment of spinal cord astrocytes.
Journal of Neuroscience Research 94(10):924 (2016)
Spinal cord injury (SCI) causes long-term disability and has no clinically effective treatment. After SCI, adenosine triphosphate (ATP) may be released from neuronal cells and astrocytes in large amounts. Our previous studies have shown that the extracellular release of ATP increases the phospho...
Association of human leukocyte antigen DP/DQ gene polymorphisms with chronic hepatitis B in Chinese Han and Uygur populations.
Infection, Genetics and Evolution 43:407 (2016)
Several genome-wide association studies (GWAS) have shown that human leukocyte antigen (HLA) DP/DQ gene polymorphisms are associated with susceptibility to chronic hepatitis B virus (HBV) infection. We clarified the roles of the HLA-DP/DQ gene in HBV infection in different nationalities. Three s...
Pharmacokinetics and tissue distribution of five active ingredients of Eucommiae cortex in normal and ovariectomized mice by UHPLC-MS/MS.
Xenobiotica 46(9):793 (2016)
1. Pinoresinol di-O-β-d-glucopyranoside (PDG), geniposide (GE), geniposidic acid (GA), aucubin (AN) and chlorogenic acid (CA) are the representative active ingredients in Eucommiae cortex (EC), which may be estrogenic. 2. The ultra high-performance liquid chromatography/tandem mass spectrometry ...
Infections in hospitalized patients with decompensated cirrhosis should be used in determining prognosis: a validation on a large Chinese cohort.
European Journal of Gastroenterology and Hepato... 28(9):1102 (2016)
Patients' and Family Members' Decision-Making and Information Disclosure Preferences in a Single-Center Survey in China: A Pilot Study.
American Journal of Hospice and Palliative Medi... 33(8):733 (2016)
Understanding the medical decision-making and information disclosure preferences is important for care quality.
To examine the feasibility of using the questionnaires and to identify modifications needed in the following study.
Thirty-three pairs of patients with advanced cancers and their careg...
Clivorine, an otonecine pyrrolizidine alkaloid from Ligularia species, impairs neuronal differentiation via NGF-induced signaling pathway in cultured PC12 cells.
Phytomedicine 23(9):931 (2016)
Pyrrolizidine alkaloids (PAs) are commonly found in many plants including those used in medical therapeutics. The hepatotoxicities of PAs have been demonstrated both in vivo and in vitro; however, the neurotoxicities of PAs are rarely mentioned.
In this study, we aimed to investigate in vitro ne...
Charge transport through dicarboxylic-acid-terminated alkanes bound to graphene-gold nanogap electrodes.
Nanoscale 8(30):14507 (2016)
Graphene-based electrodes are attractive for single-molecule electronics due to their high stability and conductivity and reduced screening compared with metals. In this paper, we use the STM-based matrix isolation I(s) method to measure the performance of graphene in single-molecule junctions w...
Sequential on-line C-terminal sequencing of peptides based on carboxypeptidase Y digestion and optically gated capillary electrophoresis with laser-induced fluorescence detection.
Journal of chromatography. A 1459:152 (2016)
We report a novel method for sequential on-line C-terminal sequencing of peptides, which combines carboxypeptidase Y (CPY) digestion with on-line derivatization and optically gated capillary electrophoresis with laser-induced fluorescence detection (OGCE-LIF). Various factors that may affect the...
Wedge energy bands of monolayer black phosphorus: a first-principles study.
Journal of Physics, Condensed Matter 28(30):305301 (2016)
On the basis of first-principles calculations, we present intriguing electronic properties of halogen-striped functionalized monolayer black phosphorus. The halogen-striped monolayer black phosphorus is found to have a wedge energy band with the energy-momentum relation of [Formula: see text] wh...
Huangqi decoction alleviates dimethylnitrosamine-induced liver fibrosis: An analysis of bile acids metabolic mechanism.
Journal of Ethnopharmacology 189:148 (2016)
Huangqi Decoction (HQD), a classical traditional Chinese medicine (TCM) formula, is used to treating liver injury in China. The aim of the study is to investigate mechanisms of HQD against dimethylnitrosamine (DMN)-induced liver fibrosis underlying metabolic profiles of bile acids.
Impact of Autologous Mesenchymal Stem Cell Infusion on Neuromyelitis Optica Spectrum Disorder: A Pilot, 2-Year Observational Study.
CNS Neuroscience & Therapeutics 22(8):677 (2016)
We evaluate safety and efficacy of autologous bone marrow-derived mesenchymal stem cells (MSCs) as a potential treatment for neuromyelitis optica spectrum disorder (NMOSD).
Fifteen patients with NMOSD were recruited. All patients received a single intravenous infusion of 1.0 × 10(8) autologous M...
Zero-fluoroscopy catheter ablation of severe drug-resistant arrhythmia guided by Ensite NavX system during pregnancy: Two case reports and literature review.
Medicine (Baltimore) 95(32):e4487 (2016)
Cardiac arrhythmias can occur during pregnancy. Owing to radiation exposure and other uncertain risks for the mother and fetus, catheter ablation has rarely been performed and is often delayed until the postpartum period. We reported 2 pregnant women who were experiencing severe arrhythmias and ...
Determination of the inhibitory effect of green tea extract on glucose-6-phosphate dehydrogenase based on multilayer capillary enzyme microreactor.
Biomedical Chromatography 30(8):1210 (2016)
Natural herbal medicines are an important source of enzyme inhibitors for the discovery of new drugs. A number of natural extracts such as green tea have been used in prevention and treatment of diseases due to their low-cost, low toxicity and good performance. The present study reports an onlin...
Fine mapping of a major locus controlling plant height using a high-density single-nucleotide polymorphism map in Brassica napus.
Theoretical and Applied Genetics 129(8):1479 (2016)
A saturated map was constructed using SNP markers to fine-map a Brassica napus dominant locus for dwarf mutant onto a 152-kb interval of chromosome A09 containing 14 genes. Major dwarf loci in crops may play important roles in crop improvement and developmental genetics. The present study invest...
The effect of cirrhosis on radiogenomic biomarker's ability to predict microvascular invasion and outcome in hepatocellular carcinoma.
Hepatology 64(2):691 (2016)
Early identification of cerebrovascular events in patients presenting with vertigo or dizziness.
International Journal of Stroke 11(6):NP64 (2016)
Cryptotanshinone induces melanoma cancer cells apoptosis via ROS-mitochondrial apoptotic pathway and impairs cell migration and invasion.
Biomedicine & Pharmacotherapy 82:319 (2016)
Melanoma is the most serious type of skin cancer because it is highly frequency of drug resistance and can spread earlier and more quickly than other skin cancers. The objective of this research was to investigate the anticancer effects of cryptotanshinone on human melanoma cells in vitro, and e...
Curcumin rescues high fat diet-induced obesity and insulin sensitivity in mice through regulating SREBP pathway.
Toxicology and Applied Pharmacology 304:99 (2016)
Obesity and its major co-morbidity, type 2 diabetes, have reached an alarming epidemic prevalence without an effective treatment available. It has been demonstrated that inhibition of SREBP pathway may be a useful strategy to treat obesity with type 2 diabetes. Sterol regulatory element-binding ...
Naringin protects cardiomyocytes against hyperglycemia-induced injuries in vitro and in vivo.
Journal of Endocrinology 230(2):197 (2016)
We previously reported that naringin (NRG) protects cardiomyocytes against high glucose (HG)-induced injuries by inhibiting the MAPK pathway. The aim of this study was to test the hypothesis that NRG prevents cardiomyocytes from hyperglycemia-induced insult through the inhibition of the nuclear ...