1. Structure-Activity Relationship of Azaindole-Based Glucokinase Activators.

    Journal of medicinal and pharmaceutical chemistry 59(2):687 (2016) PMID 26685731

    7-Azaindole has been identified as a novel bidentate anchor point for allosteric glucokinase activators. A systematic investigation around three principal parts of the new small molecule glucokinase activators led to a robust SAR in agreement with structural data that also helped to assess the c...
  2. Metalation/functionalization sequences applied to 2-bromo-3-fluoroquinolines

    Tetrahedron 61(3):717 (2005)

    Mono- and disubstituted 2-bromo-3-fluoroquinolines 3 are readily accessible. They can be converted into the 3-fluoroquinoline-2-carboxylic acids 5 by consecutive halogen/metal permutation and into the 2-bromo-3-fluoroquinoline-4-carboxylic acids ...