1. An Evolutionary Role for HIV Latency in Enhancing Viral Transmission.

    Cell 160(5):1002 (2015) PMID 25723173

    HIV latency is the chief obstacle to eradicating HIV but is widely believed to be an evolutionary accident providing no lentiviral fitness advantage. However, findings of latency being "hardwired" into HIV's gene-regulatory circuitry appear inconsistent with latency being an evolutionary acciden...
  2. An Evolutionary Role for HIV Latency in Enhancing Viral Transmission.

    Cell 160(5):1002 (2015) PMID 25723173

    HIV latency is the chief obstacle to eradicating HIV but is widely believed to be an evolutionary accident providing no lentiviral fitness advantage. However, findings of latency being "hardwired" into HIV's gene-regulatory circuitry appear inconsistent with latency being an evolutionary acciden...
  3. An Evolutionary Role for HIV Latency in Enhancing Viral Transmission

    Cell 160(5):1002 (2015)

    HIV latency is the chief obstacle to eradicating HIV but is widely believed to be an evolutionary accident providing no lentiviral fitness advantage. However, findings of latency being “hardwired” into HIV’s gene-regulatory circuitry appear inconsistent with latency being an evolutiona...
  4. An evolutionary role for HIV latency in enhancing viral transmission.

    Cell 160(5):1002 (2015) PMID 25723173 PMCID PMC4488136

    HIV latency is the chief obstacle to eradicating HIV but is widely believed to be an evolutionary accident providing no lentiviral fitness advantage. However, findings of latency being "hardwired" into HIV's gene-regulatory circuitry appear inconsistent with latency being an evolutionary acciden...
  5. A Hardwired HIV Latency Program.

    Cell 160(5):990 (2015) PMID 25723172

    Biological circuits can be controlled by two general schemes: environmental sensing or autonomous programs. For viruses such as HIV, the prevailing hypothesis is that latent infection is controlled by cellular state (i.e., environment), with latency simply an epiphenomenon of infected cells tran...
  6. A Hardwired HIV Latency Program.

    Cell 160(5):990 (2015) PMID 25723172

    Biological circuits can be controlled by two general schemes: environmental sensing or autonomous programs. For viruses such as HIV, the prevailing hypothesis is that latent infection is controlled by cellular state (i.e., environment), with latency simply an epiphenomenon of infected cells tran...
  7. Spatial tuning of acoustofluidic pressure nodes by altering net sonic velocity enables high-throughput, efficient cell sorting.

    Lab On a Chip 15(4):1000 (2015) PMID 25563937 PMCID PMC4450855

    Particle sorting using acoustofluidics has enormous potential but widespread adoption has been limited by complex device designs and low throughput. Here, we report high-throughput separation of particles and T lymphocytes (600 μL min(-1)) by altering the net sonic velocity to reposition acousti...
  8. Spatial tuning of acoustofluidic pressure nodes by altering net sonic velocity enables high-throughput, efficient cell sorting.

    Lab On a Chip 15(4):1000 (2015) PMID 25563937

    Particle sorting using acoustofluidics has enormous potential but widespread adoption has been limited by complex device designs and low throughput. Here, we report high-throughput separation of particles and T lymphocytes (600 μL min(-1)) by altering the net sonic velocity to reposition acousti...
  9. Stochastic variability in HIV affects viral eradication.

    PNAS 111(37):13251 (2014) PMID 25201951 PMCID PMC4169906

  10. Stochastic variability in HIV affects viral eradication.

    PNAS 111(37):13251 (2014) PMID 25201951 PMCID PMC4169906

  11. An Evolutionary Role for HIV Latency in Enhancing Viral Transmission

    Cell (2014)

    HIV latency is the chief obstacle to eradicating HIV, but is widely believed to be an evolutionary accident providing no lentiviral fitness advantage. However, findings of latency being ‘hardwired’ into HIV’s gene-regulatory circuitry appear inconsistent with latency being an evolution...
  12. The case for transmissible antivirals to control population-wide infectious disease.

    Trends in Biotechnology 32(8):400 (2014) PMID 25017994

    Infectious disease control faces significant challenges including: how to therapeutically target the highest-risk populations, circumvent behavioral barriers, and overcome pathogen persistence and resistance mechanisms. We review a recently proposed solution to overcome these challenges: antivir...
  13. Screening for noise in gene expression identifies drug synergies.

    Science 344(6190):1392 (2014) PMID 24903562 PMCID PMC4122234

    Stochastic fluctuations are inherent to gene expression and can drive cell-fate specification. We used such fluctuations to modulate reactivation of HIV from latency-a quiescent state that is a major barrier to an HIV cure. By screening a diverse library of bioactive small molecules, we identifi...
  14. Screening for noise in gene expression identifies drug synergies.

    Science 344(6190):1392 (2014) PMID 24903562 PMCID PMC4122234

    Stochastic fluctuations are inherent to gene expression and can drive cell-fate specification. We used such fluctuations to modulate reactivation of HIV from latency-a quiescent state that is a major barrier to an HIV cure. By screening a diverse library of bioactive small molecules, we identifi...
  15. Screening for noise in gene expression identifies drug synergies.

    Science 344(6190):1392 (2014) PMID 24903562 PMCID PMC4122234

    Stochastic fluctuations are inherent to gene expression and can drive cell-fate specification. We used such fluctuations to modulate reactivation of HIV from latency-a quiescent state that is a major barrier to an HIV cure. By screening a diverse library of bioactive small molecules, we identifi...
  16. Acoustic focusing with engineered node locations for high-performance microfluidic particle separation.

    Analyst (Cambridge UK) 139(5):1192 (2014) PMID 24448925

    Acoustofluidic devices for manipulating microparticles in fluids are appealing for biological sample processing due to their gentle and high-speed capability of sorting cell-scale objects. Such devices are generally limited to moving particles toward locations at integer fractions of the fluid c...
  17. Acoustic focusing with engineered node locations for high-performance microfluidic particle separation.

    Analyst (Cambridge UK) 139(5):1192 (2014) PMID 24448925

    Acoustofluidic devices for manipulating microparticles in fluids are appealing for biological sample processing due to their gentle and high-speed capability of sorting cell-scale objects. Such devices are generally limited to moving particles toward locations at integer fractions of the fluid c...
  18. Fifteen years later: hard and soft selection sweeps confirm a large population number for HIV in vivo.

    PLoS Genetics 10(2):e1004179 (2014) PMID 24586204 PMCID PMC3930503

  19. Fifteen years later: hard and soft selection sweeps confirm a large population number for HIV in vivo.

    PLoS Genetics 10(2):e1004179 (2014) PMID 24586204 PMCID PMC3930503

  20. Fifteen years later: hard and soft selection sweeps confirm a large population number for HIV in vivo.

    PLoS Genetics 10(2):e1004179 (2014) PMID 24586204 PMCID PMC3930503