1. 3D comparison of low, intermediate, and advanced hippocampal atrophy in MCI.

    Human Brain Mapping 31(5):786 (2010) PMID 20143386 PMCID PMC2938765

    We applied the hippocampal radial atrophy mapping technique to the baseline and follow-up magnetic resonance image data of 169 amnestic mild cognitive impairment (MCI) participants in the imaging arm of the Alzheimer's Disease Cooperative Study MCI Donepezil/Vitamin E trial. Sixty percent of the...
  2. Long-term follow-up of patients immunized with AN1792: reduced functional decline in antibody responders.

    Current Alzheimer Research 6(2):144 (2009) PMID 19355849 PMCID PMC2825665

    Immunization of patients with Alzheimer's disease (AD) with synthetic amyloid-beta peptide (Abeta(42)) (AN1792) was previously studied in a randomized, double-blind, placebo-controlled phase 2a clinical trial, Study AN1792(QS-21)-201. Treatment was discontinued following reports of encephalitis....
  3. Visuospatial deficits predict rate of cognitive decline in autopsy-verified dementia with Lewy bodies.

    Neuropsychology 22(6):729 (2008) PMID 18999346 PMCID PMC2587484

    Dementia with Lewy bodies (DLB) is often characterized by pronounced impairment in visuospatial skills, attention, and executive functions. However, the strength of the phenotypic expression of DLB varies and may be weaker in patients with extensive concomitant Alzheimer's disease (AD). To deter...
  4. High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial.

    JAMA 300(15):1774 (2008) PMID 18854539 PMCID PMC2684821

    Blood levels of homocysteine may be increased in Alzheimer disease (AD) and hyperhomocysteinemia may contribute to disease pathophysiology by vascular and direct neurotoxic mechanisms. Even in the absence of vitamin deficiency, homocysteine levels can be reduced by administration of high-dose su...
  5. Periventricular white matter hyperintensities increase the likelihood of progression from amnestic mild cognitive impairment to dementia.

    Journal of Neurology 255(9):1302 (2008) PMID 18825439 PMCID PMC2879405

    White matter hyperintensities (WMH) have an effect on cognition and are increased in severity among individuals with amnestic mild cognitive impairment (aMCI). The influence of WMH on progression of aMCI to Alzheimer's disease (AD) is less clear. Data were drawn from a three-year prospective, do...
  6. Longitudinal MRI findings from the vitamin E and donepezil treatment study for MCI.

    Neurobiology of Aging 29(9):1285 (2008) PMID 17452062 PMCID PMC2768818

    The vitamin E and donepezil trial for the treatment of amnestic mild cognitive impairment (MCI) was conducted at 69 centers in North America; 24 centers participated in an MRI sub study. The objective of this study was to evaluate the effect of treatment on MRI atrophy rates; and validate rate m...
  7. Longitudinal MRI findings from the vitamin E and donepezil treatment study for MCI.

    Neurobiology of Aging 29(9):1285 (2008) PMID 17452062 PMCID PMC2768818

    The vitamin E and donepezil trial for the treatment of amnestic mild cognitive impairment (MCI) was conducted at 69 centers in North America; 24 centers participated in an MRI sub study. The objective of this study was to evaluate the effect of treatment on MRI atrophy rates; and validate rate m...
  8. APOE genotype predicts depression in women with Alzheimer's disease: a retrospective study.

    International Journal of Geriatric Psychiatry 23(6):632 (2008) PMID 18058831 PMCID PMC2583456

    The association between the APOE epsilon4 allele and depression was investigated in a retrospective study of 323 AD patients. Patients were divided into demographically comparable groups based on the presence or absence of depression. Results showed that the frequency of APOE epsilon4 allele was...
  9. APOE genotype predicts depression in women with Alzheimer's disease: a retrospective study.

    International Journal of Geriatric Psychiatry 23(6):632 (2008) PMID 18058831 PMCID PMC2583456

    The association between the APOE epsilon4 allele and depression was investigated in a retrospective study of 323 AD patients. Patients were divided into demographically comparable groups based on the presence or absence of depression. Results showed that the frequency of APOE epsilon4 allele was...
  10. Cognitive discrepancies versus APOE genotype as predictors of cognitive decline in normal-functioning elderly individuals: a longitudinal study.

    American Journal of Geriatric Psychiatry 16(5):366 (2008) PMID 18448849 PMCID PMC3050584

    Cognitive-discrepancy analysis has been shown to be a useful technique for detecting subtle cognitive deficits in normal-functioning elderly individuals who are genetically at-risk for Alzheimer disease (AD). However, studies that have used cognitive-discrepancy measures to date have used retros...
  11. Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease.

    Human Molecular Genetics 17(5):759 (2008) PMID 18063669

    Late-onset Alzheimer's disease (LOAD) and Parkinson's disease (PD) are the most common neurodegenerative disorders and in both diseases susceptibility is known to be influenced by genes. We set out to identify novel susceptibility genes for LOAD by performing a large scale, multi-tiered associat...
  12. Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease.

    Human Molecular Genetics 17(5):759 (2008) PMID 18063669

    Late-onset Alzheimer's disease (LOAD) and Parkinson's disease (PD) are the most common neurodegenerative disorders and in both diseases susceptibility is known to be influenced by genes. We set out to identify novel susceptibility genes for LOAD by performing a large scale, multi-tiered associat...
  13. Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease.

    Human Molecular Genetics 17(5):759 (2008) PMID 18063669

    Late-onset Alzheimer's disease (LOAD) and Parkinson's disease (PD) are the most common neurodegenerative disorders and in both diseases susceptibility is known to be influenced by genes. We set out to identify novel susceptibility genes for LOAD by performing a large scale, multi-tiered associat...
  14. Rofecoxib in patients with mild cognitive impairment: further analyses of data from a randomized, double-blind, trial.

    Current Alzheimer Research 5(1):73 (2008) PMID 18288935

    A recent clinical trial in patients with Mild Cognitive Impairment (MCI) found an increased rate of possible or probable Alzheimer's disease (AD) diagnoses in patients assigned to rofecoxib compared to placebo. This unexpected finding was difficult to interpret due to methodological issues and a...
  15. Rofecoxib in patients with mild cognitive impairment: further analyses of data from a randomized, double-blind, trial.

    Current Alzheimer Research 5(1):73 (2008) PMID 18288935

    A recent clinical trial in patients with Mild Cognitive Impairment (MCI) found an increased rate of possible or probable Alzheimer's disease (AD) diagnoses in patients assigned to rofecoxib compared to placebo. This unexpected finding was difficult to interpret due to methodological issues and a...
  16. Progressive impairment on neuropsychological tasks in a longitudinal study of preclinical Alzheimer's disease.

    Neuropsychology 21(6):696 (2007) PMID 17983283

    Previous research suggests that patients with Alzheimer's disease exhibit cognitive impairment in the years preceding a clinical diagnosis. Memory impairments are particularly pronounced, but the relative degree to which other cognitive functions are impaired and the speed with which they declin...
  17. Density of the brain, decline of the mind: an atypical case of Fahr disease.

    Archives of Neurology 64(5):756 (2007) PMID 17502478

  18. Density of the brain, decline of the mind: an atypical case of Fahr disease.

    Archives of Neurology 64(5):756 (2007) PMID 17502478

  19. Verbal paired-associate learning by APOE genotype in non-demented older adults: fMRI evidence of a right hemispheric compensatory response.

    Neurobiology of Aging 28(2):238 (2007) PMID 16434125 PMCID PMC1705815

    Previous studies of episodic memory report a greater extent of blood-oxygenation-level-dependent (BOLD) response in non-demented older adults with the apolipoprotein E epsilon-4 (APOE epsilon4) allele than in those without the allele. We conducted a functional MRI study to investigate whether AP...
  20. Disparate letter and semantic category fluency deficits in autopsy-confirmed frontotemporal dementia and Alzheimer's disease.

    Neuropsychology 21(1):20 (2007) PMID 17201527

    Patients with autopsy-confirmed frontotemporal dementia (FTD; n = 16) and Alzheimer's disease (AD; n = 32) were compared on first-letter and semantic category fluency tasks. Despite being matched on age, education, and dementia severity, FTD patients performed worse overall and showed similar im...