Principal components analysis of agitation outcomes in Alzheimer's disease.
Journal of Psychiatric Research 79:4 (2016)
We developed a composite measure of agitation as a secondary outcome of change over time in the Citalopram for Agitation in Alzheimer's disease study (CitAD). CitAD demonstrated a positive effect of citalopram on agitation on the Neurobehavioral Rating Scale agitation subscale (NBRS-A). CitAD in...
Negative Tuberculin Skin Test and Prediction of Reversion of QuantiFERON Interferon Gamma Release Assay in US Healthcare Workers.
Infection Control and Hospital Epidemiology 37(4):478 (2016)
QuantiFERON tuberculosis tests (QFT) reverted in (612) 77% of 1,094 low-risk healthcare workers (HCW) testing less than 1.16 IU/mL. Of HCW testing greater than 1.1 IU/mL, 33 (59%) of 56 with negative tuberculin skin tests (TST) reverted vs 8 (6%) of 125 with positive TSTs. Retesting low-risk QFT...
Sedation mediates part of Citalopram's effect on agitation in Alzheimer's disease.
Journal of Psychiatric Research 74:17 (2016)
We found a benefit of citalopram for agitation in the Citalopram for Agitation in Alzheimer's Disease study (CitAD), and wondered if this was mediated by a sedative effect. CitAD was a randomized, placebo-controlled, double-blind, parallel group trial conducted at 8 academic centers in the Unite...
Ubiquity of Undiagnosed Sleep Disordered Breathing in Community-Dwelling Older Male Veterans.
American Journal of Geriatric Psychiatry 24(2):170 (2016)
To determine the point prevalence of sleep disordered breathing (SDB) in a community-based sample of older male veterans and to determine if common markers of SDB apply to this population.
Two hundred fourteen older male Veterans (age 55-89 years) were recruited for a study on post-traumatic str...
Increased Prevalence of Sleep Disordered Breathing in Older Veterans with PTSD
American Journal of Geriatric Psychiatry 23(3):S180 (2015)
Verbal naming test for use with older adults: development and initial validation.
International Neuropsychological Society. Journal 21(3):239 (2015)
Naming or word-finding tasks are a mainstay of the typical neuropsychological evaluation, particularly with older adults. However, many older adults have significant visual impairment and there are currently no such word-finding tasks developed for use with older visually impaired populations. T...
Tumor microenvironment promotes dicarboxylic acid carrier-mediated transport of succinate to fuel prostate cancer mitochondria.
American journal of cancer research 5(5):1665 (2015)
Prostate cancer cells reprogram their metabolism, so that they support their elevated oxidative phosphorylation and promote a cancer friendly microenvironment. This work aimed to explore the mechanisms that cancer cells employ for fueling themselves with energy rich metabolites available in inte...
Nocturia reported in nightly sleep diaries: common occurrence with significant implications?
Health Psychology 33(11):1362 (2014)
Nocturia (nocturnal awakenings associated with urination) is so common a nocturnal behavior that its association with poor sleep is often overlooked. This study examined nocturia and its potential role in poor sleep by examining reported nightly awakenings and associated bathroom trips.
The evidence base of sleep restriction therapy for treating insomnia disorder.
Sleep Medicine Reviews 18(5):415 (2014)
Sleep restriction therapy is routinely used within cognitive behavioral therapy to treat chronic insomnia. However, the efficacy for sleep restriction therapy as a standalone intervention has yet to be comprehensively reviewed. This review evaluates the evidence for the use of sleep restriction ...
ACTIGRAPHIC MOTOR ACTIVITY IN MCI PATIENTS CARRYING OUT SHORT FUNCTIONAL ACTIVITY TASKS
Alzheimer's & Dementia 10(4):P692 (2014)
Actigraphic motor activity in mild cognitive impairment patients carrying out short functional activity tasks: comparison between mild cognitive impairment with and without depressive symptoms.
Journal of Alzheimer's Disease 40(4):869 (2014)
Individuals with mild cognitive impairment (MCI) may exhibit changes in motor activity in conducting their activities of daily living. Depression, one of the most frequent neuropsychiatric symptoms, might affect motor activity in MCI.
To assess motor activity in MCI subjects carrying out short f...
Longitudinal assessment of sleep disordered breathing in Vietnam veterans with post-traumatic stress disorder.
Nature and Science of Sleep 6:123 (2014)
Previous work has demonstrated the relatively high prevalence of risk factors for cognitive impairment, such as sleep disordered breathing (SDB) and obesity, in Vietnam War era veterans with post-traumatic stress disorder (PTSD). No data are currently available on the longitudinal stability of S...
Effects of body mass index-related disorders on cognition: preliminary results.
Diabetes Metabolic Syndrome and Obesity Targets... 7:145 (2014)
Well-known risk factors for cognitive impairment are also associated with obesity. Research has highlighted genetic risk factors for obesity, yet the relationship of those risk factors with cognitive impairment is unknown. The objective of this study was to determine the associations between cog...
Management of apathy in nursing homes using a teaching program for care staff: the STIM-EHPAD study.
International Journal of Geriatric Psychiatry 28(4):383 (2013)
This study aimed to evaluate the effectiveness of a nursing home (NH) staff education to manage apathy in older individuals with a diagnosis of dementia.
Sixteen NHs agreed to participate, and 230 demented apathetic residents were randomly assigned to the reference group (RG) or the intervention...
Phenotyping apathy in individuals with Alzheimer disease using functional principal component analysis.
American Journal of Geriatric Psychiatry 21(4):391 (2013)
To determine if there is a specific pattern of gross motor activity associated with apathy in individuals with Alzheimer disease (AD).
Examination of ad libitum 24-hour ambulatory gross motor activity patterns.
Ninety-two individuals with AD, 35 of whom had apathy...
Nocturia compounds nocturnal wakefulness in older individuals with insomnia.
Journal of clinical sleep medicine : JCSM : off... 9(3):259 (2013)
To determine the impact of nocturia on objective measures of sleep in older individuals with insomnia.
The sleep and toileting patterns of a group of community-dwelling older men (n = 55, aged 64.3 ± 7.52 years) and women (n = 92, aged 62.5 ± 6.73 years) with insomnia were studied for two weeks ...
Modeling the effects of obstructive sleep apnea and hypertension in Vietnam veterans with PTSD.
Sleep and Breathing 16(4):1201 (2012)
The present work aimed to extend models suggesting that obstructive sleep apnea (OSA) is associated with worse cognitive performance in community-dwelling older adults. We hypothesized that in addition to indices of OSA severity, hypertension is associated with worse cognitive performance in suc...
Decreased daytime motor activity associated with apathy in Alzheimer disease: an actigraphic study.
American Journal of Geriatric Psychiatry 20(9):806 (2012)
Across all stages of Alzheimer disease (AD), apathy is the most common neuropsychiatric symptom. Studies using the Neuropsychiatric Inventory (NPI) have found that apathy is present in up to 70% of individuals with Alzheimer disease. One of the main difficulties in assessing apathy and other neu...
Brief morning light treatment for sleep/wake disturbances in older memory-impaired individuals and their caregivers.
Sleep Medicine 13(5):546 (2012)
Scheduled exposure to bright light (phototherapy) has been used, with varying degrees of success, to treat sleep disruption in older individuals. Most of these studies have been done in institutional settings and have used several hours of daily light exposure. Such a regimen in the home setting...
Dissemination of CBTI to the non-sleep specialist: protocol development and training issues.
Journal of clinical sleep medicine : JCSM : off... 8(2):209 (2012)
Strong evidence supports the efficacy of cognitive behavioral therapy for insomnia (CBTI). A significant barrier to wide dissemination of CBTI is the lack of qualified practitioners. We describe challenges and decisions made when developing a CBTI dissemination program in the Veterans Health Adm...