1. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.

    Genes & Development 24(13):1403 (2010) PMID 20595232 PMCID PMC2895199

    The sterol regulatory element-binding protein (SREBP) transcription factor family is a critical regulator of lipid and sterol homeostasis in eukaryotes. In mammals, SREBPs are highly active in the fed state to promote the expression of lipogenic and cholesterogenic genes and facilitate fat stora...
  2. Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3.

    Protein Science 18(3):514 (2009) PMID 19241369 PMCID PMC2760358

    SIRT3 is a key mitochondrial protein deacetylase proposed to play key roles in regulating mitochondrial metabolism but there has been considerable debate about its actual size, the sequences required for activity, and its subcellular localization. A previously cloned mouse SIRT3 has high sequenc...
  3. Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo.

    BMC Systems Biology 3:31 (2009) PMID 19284563 PMCID PMC2660283

    Calorie restriction (CR) produces a number of health benefits and ameliorates diseases of aging such as type 2 diabetes. The components of the pathways downstream of CR may provide intervention points for developing therapeutics for treating diseases of aging. The NAD+-dependent protein deacetyl...