1. A Novel Peroxisome Proliferator-activated Receptor (PPAR)α Agonist and PPARγ Antagonist, Z-551, Ameliorates High-fat Diet-induced Obesity and Metabolic Disorders in Mice.

    Journal of Biological Chemistry 290(23):14567 (2015) PMID 25907553 PMCID PMC4505524

    A novel peroxisome proliferator-activated receptor (PPAR) modulator, Z-551, having both PPARα agonistic and PPARγ antagonistic activities, has been developed for the treatment of obesity and obesity-related metabolic disorders. We examined the effects of Z-551 on obesity and the metabolic disord...
  2. Insulin receptor substrate-2 (irs2) in endothelial cells plays a crucial role in insulin secretion.

    Diabetes 64(3):876 (2015) PMID 25277391

    Endothelial cells are considered to be essential for normal pancreatic β-cell function. The current study attempted to demonstrate the role of insulin receptor substrate-2 (Irs2) in endothelial cells with regard to insulin secretion. Endothelial cell-specific Irs2 knockout (ETIrs2KO) mice exhibi...
  3. Insulin receptor substrate-2 (Irs2) in endothelial cells plays a crucial role in insulin secretion.

    Diabetes 64(3):876 (2015) PMID 25277391

    Endothelial cells are considered to be essential for normal pancreatic β-cell function. The current study attempted to demonstrate the role of insulin receptor substrate-2 (Irs2) in endothelial cells with regard to insulin secretion. Endothelial cell-specific Irs2 knockout (ETIrs2KO) mice exhibi...
  4. [Thiazolidine, thiazolidinediones, TZD].

    Nippon rinsho. Japanese journal of clinical med... 73(3):402 (2015) PMID 25812365

    In addition to a good efficacy to lower blood glucose without hypoglycemia, thiazolidinediones(TZDs) have been proved to have the effects to increase plasma adiponectin, and actually decrease the cardiovascular events in several randomized clinical trials, while some adverse effects have also be...
  5. Association between Washing Residue on the Feet and Tinea Pedis in Diabetic Patients.

    Nursing Research and Practice 2015:872678 (2015) PMID 25793125 PMCID PMC4352499

    Tinea pedis (TP) may lead to the development of foot ulcers in diabetic patients; thus, its prevention in diabetic patients is important. TP occurs after dermatophytes on the skin scales of TP patients attach to the feet. Therefore, it is necessary to remove the scales and dermatophytes, and thi...
  6. Effect of renal impairment on the pharmacokinetics, pharmacodynamics, and safety of empagliflozin, a sodium glucose cotransporter 2 inhibitor, in Japanese patients with type 2 diabetes mellitus.

    Clinical Therapeutics 36(11):1606 (2014) PMID 25199997

    The purpose of this study was to assess the effect of renal impairment on the pharmacokinetic, pharmacodynamic, and safety profiles of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, in Japanese patients with type 2 diabetes mellitus (T2DM). In an open-label, parallel-group st...
  7. Effect of Renal Impairment on the Pharmacokinetics, Pharmacodynamics, and Safety of Empagliflozin, a Sodium Glucose Cotransporter 2 Inhibitor, in Japanese Patients With Type 2 Diabetes Mellitus

    Clinical Therapeutics 36(11):1606 (2014)

    Purpose The purpose of this study was to assess the effect of renal impairment on the pharmacokinetic, pharmacodynamic, and safety profiles of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, in Japanese patients with type 2 diabetes mellitus (T2DM).
  8. Effect of renal impairment on the pharmacokinetics, pharmacodynamics, and safety of empagliflozin, a sodium glucose cotransporter 2 inhibitor, in Japanese patients with type 2 diabetes mellitus.

    Clinical Therapeutics 36(11):1606 (2014) PMID 25199997

    The purpose of this study was to assess the effect of renal impairment on the pharmacokinetic, pharmacodynamic, and safety profiles of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, in Japanese patients with type 2 diabetes mellitus (T2DM). In an open-label, parallel-group st...
  9. Elevated plantar pressure in diabetic patients and its relationship with their gait features

    Gait & Posture 40(3):408 (2014)

    • We revealed the relationship of elevated plantar pressure and gait features in diabetic patients. • We identified the elevated plantar pressure in diabetic patie...
  10. Elevated plantar pressure in diabetic patients and its relationship with their gait features.

    Gait & Posture 40(3):408 (2014) PMID 24974127

    High plantar pressure is a major risk factor for diabetic foot ulcers. The relationship between plantar pressure and foot mobility has been investigated in some studies. However, when the foot is in motion, foot mobility is only a small feature of the gait. Therefore, we investigated relationshi...
  11. Deregulation of pancreas-specific oxidoreductin ERO1β in the pathogenesis of diabetes mellitus.

    Molecular and Cellular Biology 34(7):1290 (2014) PMID 24469402 PMCID PMC3993575

    A growing body of evidence has underlined the significance of endoplasmic reticulum (ER) stress in the pathogenesis of diabetes mellitus. ER oxidoreductin 1β (ERO1β) is a pancreas-specific disulfide oxidase that is known to be upregulated in response to ER stress and to promote protein folding i...
  12. Deregulation of pancreas-specific oxidoreductin ERO1β in the pathogenesis of diabetes mellitus.

    Molecular and Cellular Biology 34(7):1290 (2014) PMID 24469402 PMCID PMC3993575

    A growing body of evidence has underlined the significance of endoplasmic reticulum (ER) stress in the pathogenesis of diabetes mellitus. ER oxidoreductin 1β (ERO1β) is a pancreas-specific disulfide oxidase that is known to be upregulated in response to ER stress and to promote protein folding i...
  13. Body composition is the main determinant for the difference in type 2 diabetes pathophysiology between Japanese and Caucasians.

    Diabetes Care 37(3):796 (2014) PMID 24130359

    OBJECTIVE This cross-sectional clinical study compared the pathophysiology of type 2 diabetes in Japanese and Caucasians and investigated the role of demographic, genetic, and lifestyle-related risk factors for insulin resistance and β-cell response. RESEARCH DESIGN AND METHODS A total of 120 Ja...
  14. TCF7L2 in mouse pancreatic beta cells plays a crucial role in glucose homeostasis by regulating beta cell mass.

    Diabetologia 57(3):542 (2014) PMID 24317852

    Common genetic variations of the transcription factor 7-like 2 gene (encoded by TCF7L2), one of the T cell factor/lymphoid enhancer-binding factor transcription factors for the converging wingless-type MMTV integration site family (Wnt)/β-catenin signalling pathway, are known to be associated wi...
  15. TCF7L2 in mouse pancreatic beta cells plays a crucial role in glucose homeostasis by regulating beta cell mass.

    Diabetologia 57(3):542 (2014) PMID 24317852

    Common genetic variations of the transcription factor 7-like 2 gene (encoded by TCF7L2), one of the T cell factor/lymphoid enhancer-binding factor transcription factors for the converging wingless-type MMTV integration site family (Wnt)/β-catenin signalling pathway, are known to be associated wi...
  16. Body composition is the main determinant for the difference in type 2 diabetes pathophysiology between Japanese and Caucasians.

    Diabetes Care 37(3):796 (2014) PMID 24130359

    OBJECTIVE This cross-sectional clinical study compared the pathophysiology of type 2 diabetes in Japanese and Caucasians and investigated the role of demographic, genetic, and lifestyle-related risk factors for insulin resistance and β-cell response. RESEARCH DESIGN AND METHODS A total of 120 Ja...
  17. Protocol for a large-scale prospective observational study with alogliptin in patients with type 2 diabetes: J-BRAND Registry.

    BMJ Open 4(9):e004760 (2014) PMID 25227623 PMCID PMC4166248

    Dipeptidyl peptidase-4 (DPP-4) inhibitors including alogliptin are categorised as a newer class of oral hypoglycaemic, antidiabetic drugs to suppress the degradation of incretin hormones ((glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)) by DPP-4. We have s...
  18. Lung abscess without sepsis in a patient with diabetes with refractory episodes of spontaneous hypoglycemia: a case report and review of the literature.

    Journal of Medical Case Reports 8:51 (2014) PMID 24524438 PMCID PMC3930005

    Hypoglycemia is a cause of considerable morbidity. Although hypoglycemia has been documented in the setting of septic shock and has been associated with higher mortality, hypoglycemia in infection without sepsis has not been reported in the literature. A 72-year-old Japanese woman treated with h...
  19. Protocol for a large-scale prospective observational study with alogliptin in patients with type 2 diabetes: J-BRAND Registry.

    BMJ Open 4(9):e004760 (2014) PMID 25227623 PMCID PMC4166248

    Dipeptidyl peptidase-4 (DPP-4) inhibitors including alogliptin are categorised as a newer class of oral hypoglycaemic, antidiabetic drugs to suppress the degradation of incretin hormones ((glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)) by DPP-4. We have s...
  20. Lung abscess without sepsis in a patient with diabetes with refractory episodes of spontaneous hypoglycemia: a case report and review of the literature.

    Journal of Medical Case Reports 8:51 (2014) PMID 24524438 PMCID PMC3930005

    Hypoglycemia is a cause of considerable morbidity. Although hypoglycemia has been documented in the setting of septic shock and has been associated with higher mortality, hypoglycemia in infection without sepsis has not been reported in the literature. A 72-year-old Japanese woman treated with h...