1. Behavioural characterization of neuregulin 1 type I overexpressing transgenic mice.

    Neuroreport 20(17):1523 (2009) PMID 19829162 PMCID PMC2880453

    Neuregulin 1 (NRG1) is a pleiotropic growth factor involved in diverse aspects of brain development and function. In schizophrenia, expression of the NRG1 type I isoform is selectively increased. However, virtually nothing is known about the roles of this isoform in brain. We have studied transg...
  2. Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system.

    Neuron 59(4):581 (2008) PMID 18760695 PMCID PMC2628490

    Understanding the control of myelin formation by oligodendrocytes is essential for treating demyelinating diseases. Neuregulin-1 (NRG1) type III, an EGF-like growth factor, is essential for myelination in the PNS. It is thus thought that NRG1/ErbB signaling also regulates CNS myelination, a view...
  3. Origin of CD11b+ macrophage-like cells in the CNS of PLP-overexpressing mice: Low influx of haematogenous macrophages and unchanged blood-brain-barrier in the optic nerve

    Molecular and Cellular Neuroscience 38(4):489 (2008) PMID 18555697

    We have recently reported that overexpression of proteolipid protein in oligodendrocytes leads to a pathologically relevant increase of both CD8+ T-lymphocytes and CD11b+ cells in the CNS. We now focussed on the origin of the CD11b+ cells in the optic nerve, a well established structure for...
  4. Origin of CD11b+ macrophage-like cells in the CNS of PLP-overexpressing mice: Low influx of haematogenous macrophages and unchanged blood-brain-barrier in the optic nerve

    Molecular and Cellular Neuroscience 38(4):489 (2008) PMID 18555697

    We have recently reported that overexpression of proteolipid protein in oligodendrocytes leads to a pathologically relevant increase of both CD8+ T-lymphocytes and CD11b+ cells in the CNS. We now focussed on the origin of the CD11b+ cells in the optic nerve, a well established structure for...
  5. The transcription factor Yin Yang 1 is essential for oligodendrocyte progenitor differentiation.

    Neuron 55(2):217 (2007) PMID 17640524 PMCID PMC2034312

    The progression of progenitors to oligodendrocytes requires proliferative arrest and the activation of a transcriptional program of differentiation. While regulation of cell cycle exit has been extensively characterized, the molecular mechanisms responsible for the initiation of differentiation ...
  6. The Transcription Factor Yin Yang 1 Is Essential for Oligodendrocyte Progenitor Differentiation

    Neuron 55(2):217 (2007)

    The progression of progenitors to oligodendrocytes requires proliferative arrest and the activation of a transcriptional program of differentiation. While regulation of cell cycle exit has been extensively characterized, the molecular mechanisms responsible for the initiation of differentia...
  7. FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies.

    Neuron 40(3):501 (2003) PMID 14642275 PMCID PMC2758566

    Targeted deletion of focal adhesion kinase (fak) in the developing dorsal forebrain resulted in local disruptions of the cortical basement membrane located between the neuroepithelium and pia-meninges. At disruption sites, clusters of neurons invaded the marginal zone. Retraction of radial glial...