Orally administered manganese with and without ascorbic acid as a liver-specific contrast agent and bowel marker for magnetic resonance imaging: phase I clinical trial assessing efficacy and safety.
Investigative Radiology 45(9):559 (2010)
The objectives of this clinical trial of orally administered manganese in magnetic resonance imaging (MRI) of the liver were to assess signal enhancements in the liver with and without the addition of an uptake promoter, ascorbic acid, and to evaluate acute safety.
A total of 18 healthy adult ma...
Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate.
Nature 453(7197):940 (2008)
As alterations in tissue pH underlie many pathological processes, the capability to image tissue pH in the clinic could offer new ways of detecting disease and response to treatment. Dynamic nuclear polarization is an emerging technique for substantially increasing the sensitivity of magnetic re...
Cardiac metabolism measured noninvasively by hyperpolarized 13C MRI.
Magnetic Resonance in Medicine 59(5):1005 (2008)
Pyruvate is included in the energy production of the heart muscle and is metabolized into lactate, alanine, and CO(2) in equilibrium with HCO(3) (-). The aim of this study was to evaluate the feasibility of using (13)C hyperpolarization enhanced MRI to monitor pyruvate metabolism in the heart du...
Iodixanol 320 results in better renal tolerance and radiodensity than do gadolinium-based contrast media: arteriography in ischemic porcine kidneys.
Radiology 247(1):88 (2008)
To prospectively compare nephrotoxicity and radiodensity of plasma hyperosmotic gadolinium chelates (attenuation-osmotic ratio of 1:1) with those of plasma iso-osmotic iodine-based contrast media (attenuation-osmotic ratio of 3:1 or 6:1) after renal arteriography in ischemic porcine kidneys.
Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.
Nature Medicine 13(11):1382 (2007)
Measurements of early tumor responses to therapy have been shown, in some cases, to predict treatment outcome. We show in lymphoma-bearing mice injected intravenously with hyperpolarized [1-(13)C]pyruvate that the lactate dehydrogenase-catalyzed flux of (13)C label between the carboxyl groups of...
Passive catheter tracking during interventional MRI using hyperpolarized 13C.
Magnetic Resonance in Medicine 57(6):1140 (2007)
Interventional procedures in MRI can be performed preclinically using active or passive catheter-tracking methods. A novel passive nonproton technique is suggested that uses a catheter filled with a hyperpolarized (13)C contrast agent. A prototype three-lumen catheter was built with two closed l...
Hyperpolarized 13C MRI of the pulmonary vasculature and parenchyma.
Magnetic Resonance in Medicine 57(3):459 (2007)
The study of lung perfusion in normal and diseased subjects is of great interest to physiologists and physicians. In this work we demonstrate the application of a liquid-phase hyperpolarized (HP) carbon-13 ((13)C) tracer to magnetic resonance imaging (MRI) of the pulmonary vasculature and pulmon...
Gadolinium contrast media are more nephrotoxic than iodine media. The importance of osmolality in direct renal artery injections.
European Radiology 16(12):2712 (2006)
A study was undertaken of the role of osmotoxicity in gadolinium (Gd) and iodine contrast media (CM) nephrotoxicity in ischemic porcine kidneys. Test solutions: mannitol iso-osmotic to 0.5 M: gadopentetate (1.96 Osm/kg H2O), 0.5 M: gadodiamide (0.78 Osm/kg H2O) and 0.5 M: iohexol (190 mg I/ml, 0...
Metabolic imaging by hyperpolarized 13C magnetic resonance imaging for in vivo tumor diagnosis.
Cancer Research 66(22):10855 (2006)
The "Warburg effect," an elevation in aerobic glycolysis, may be a fundamental property of cancer cells. For cancer diagnosis and treatment, it would be valuable if elevated glycolytic metabolism could be quantified in an image in animals and humans. The pyruvate molecule is at the metabolic cro...
Metabolic imaging and other applications of hyperpolarized 13C1.
Academic Radiology 13(8):932 (2006)
Real-time metabolic imaging.
PNAS 103(30):11270 (2006)
The endogenous substance pyruvate is of major importance to maintain energy homeostasis in the cells and provides a window to several important metabolic processes essential to cell survival. Cell viability is therefore reflected in the metabolism of pyruvate. NMR spectroscopy has until now been...
MR coronary angiography in pigs with intraarterial injections of a hyperpolarized 13C substance.
Magnetic Resonance in Medicine 55(4):731 (2006)
A new diagnostic application of a water-soluble contrast medium (CM) based on the hyperpolarization of a 13C substance is introduced. The degree of polarization achieved is >30%, which is about a factor of 10(5) higher than the thermal equilibrium polarization level at 1.5 T. Imaging of hyperpol...
13C imaging-a new diagnostic platform.
European Radiology 16(1):57 (2006)
The evolution of magnetic resonance imaging (MRI) has been astounding since the early 1980s, and a broad range of applications has emerged. To date, clinical imaging of nuclei other than protons has been precluded for reasons of sensitivity. However, with the recent development of hyperpolarizat...
Metabolic Imaging and Other Applications of Hyperpolarized13C1
Academic Radiology 13(8):932 (2006)
3He MRI-based assessment of posture-dependent regional ventilation gradients in rats.
Journal of Applied Physiology 98(6):2259 (2005)
A recently developed method for quantitative assessment of regional lung ventilation was employed for the study of posture-dependent ventilation differences in rats. The measurement employed hyperpolarized (3)He MRI to detect the build-up of the signal intensity after increasing numbers of (3)He...
Regarding "Safety of gadolinium contrast angiography in patients with chronic renal insufficiency".
Journal of Vascular Surgery 40(1):204; author reply 204 (2004)
Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccaride disease model using hyperpolarized 129Xe.
Magnetic Resonance in Medicine 50(6):1170 (2003)
The ability to quantify pulmonary diffusing capacity and perfusion using dynamic hyperpolarized (129)Xe NMR spectroscopy is demonstrated. A model of alveolar gas exchange was developed, which, in conjunction with (129)Xe NMR, enables quantification of average alveolar wall thickness, pulmonary p...
Increase of signal-to-noise of more than 10,000 times in liquid state NMR.
Discovery medicine 3(19):37 (2003)
Extract: Two major applications exist for Nuclear Magnetic Resonance (NMR): spectroscopy and imaging. NMR spectroscopy has gained acceptance as one of the major analytical techniques, due to the detailed information that can be obtained about molecular structure, dynamics and intra- and inter-mo...
Molecular imaging with endogenous substances.
PNAS 100(18):10435 (2003)
Dynamic nuclear polarization has enabled hyperpolarization of nuclei such as 13C and 15N in endogenous substances. The resulting high nuclear polarization makes it possible to perform subsecond 13C MRI. By using the dynamic nuclear polarization hyperpolarization technique, 10% polarization was o...
Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR.
PNAS 100(18):10158 (2003)
A method for obtaining strongly polarized nuclear spins in solution has been developed. The method uses low temperature, high magnetic field, and dynamic nuclear polarization (DNP) to strongly polarize nuclear spins in the solid state. The solid sample is subsequently dissolved rapidly in a suit...