1. Convergent findings for abnormalities of the NF-κB signaling pathway in schizophrenia.

    PMID 23132271 PMCID PMC3547205

    Neurons exhibit a constitutive level of nuclear factor-κB (NF-κB) signaling and this pathway plays a significant role in neurite outgrowth, activity-dependent plasticity, and cognitive function. Transcription factor analysis was performed in a microarray data set profiled in four different brain...
  2. Convergent findings for abnormalities of the NF-κB signaling pathway in schizophrenia.

    PMID 23132271 PMCID PMC3547205

    Neurons exhibit a constitutive level of nuclear factor-κB (NF-κB) signaling and this pathway plays a significant role in neurite outgrowth, activity-dependent plasticity, and cognitive function. Transcription factor analysis was performed in a microarray data set profiled in four different brain...
  3. A system-level transcriptomic analysis of schizophrenia using postmortem brain tissue samples.

    Archives of General Psychiatry 69(12):1205 (2012) PMID 22868662

    CONTEXT Schizophrenia is a common, highly heritable, neurodevelopmental mental illness, characterized by genetic heterogeneity. OBJECTIVE To identify abnormalities in the transcriptome organization among older persons with schizophrenia and controls. DESIGN Weighted gene coexpression network ana...
  4. Molecular and genetic evidence for abnormalities in the nodes of Ranvier in schizophrenia.

    Archives of General Psychiatry 69(1):7 (2012) PMID 21893642

    Genetic, neuroimaging, and molecular neurobiological evidence support the hypothesis that the disconnectivity syndrome in schizophrenia (SZ) could arise from failures of saltatory conduction and abnormalities at the nodes of Ranvier (NOR) interface where myelin and axons interact. To identify ab...
  5. Molecular and genetic evidence for abnormalities in the nodes of Ranvier in schizophrenia.

    Archives of General Psychiatry 69(1):7 (2012) PMID 21893642

    Genetic, neuroimaging, and molecular neurobiological evidence support the hypothesis that the disconnectivity syndrome in schizophrenia (SZ) could arise from failures of saltatory conduction and abnormalities at the nodes of Ranvier (NOR) interface where myelin and axons interact. To identify ab...
  6. Molecular and genetic evidence for abnormalities in the nodes of Ranvier in schizophrenia.

    Archives of General Psychiatry 69(1):7 (2012) PMID 21893642

    Genetic, neuroimaging, and molecular neurobiological evidence support the hypothesis that the disconnectivity syndrome in schizophrenia (SZ) could arise from failures of saltatory conduction and abnormalities at the nodes of Ranvier (NOR) interface where myelin and axons interact. To identify ab...
  7. The brain's emotional foundations of human personality and the Affective Neuroscience Personality Scales.

    Neuroscience & Biobehavioral Reviews 35(9):1946 (2011) PMID 21527289

    Six of the primary-process subcortical brain emotion systems - SEEKING, RAGE, FEAR, CARE, GRIEF and PLAY - are presented as foundational for human personality development, and hence as a potentially novel template for personality assessment as in the Affective Neurosciences Personality Scales (A...
  8. Expression of mutant human DISC1 in mice supports abnormalities in differentiation of oligodendrocytes.

    Schizophrenia Research 130(1-3):238 (2011) PMID 21605958 PMCID PMC3139741

    Abnormalities in oligodendrocyte (OLG) differentiation and OLG gene expression deficit have been described in schizophrenia (SZ). Recent studies revealed a critical requirement for Disrupted-in-Schizophrenia 1 (DISC1) in neural development. Transgenic mice with forebrain restricted expression of...
  9. Pimozide augmentation of clozapine inpatients with schizophrenia and schizoaffective disorder unresponsive to clozapine monotherapy.

    PMID 21346734 PMCID PMC3077468

    Despite its superior efficacy, clozapine is helpful in only a subset of patients with schizophrenia unresponsive to other antipsychotics. This lack of complete success has prompted the frequent use of various clozapine combination strategies despite a paucity of evidence from randomized controll...
  10. Linking oligodendrocyte and myelin dysfunction to neurocircuitry abnormalities in schizophrenia.

    Progress in Neurobiology 93(1):13 (2011) PMID 20950668 PMCID PMC3622281

    Multiple lines of evidence in schizophrenia, from brain imaging, studies in postmortem brains, and genetic association studies, have implicated oligodendrocyte and myelin dysfunction in this disease. Recent studies suggest that oligodendrocyte and myelin dysfunction leads to changes in synaptic ...
  11. Microarray database mining and cell differentiation defects in schizophrenia.

    Advances in Experimental Medicine and Biology 696:67 (2011) PMID 21431547

    The causes of schizophrenia remain unknown, but a key role of oligodendrocytes and of the myelination process carried out by them has gained increasing support. The adult human brain parenchyma contains a relatively large population of progenitor cells that can generate oligodendrocytes. Defects...
  12. The effects of hypertension and body mass index on cognition in schizophrenia.

    American Journal of Psychiatry 167(10):1232 (2010) PMID 20634363

    In recent years there has been a greater appreciation of the elevated prevalence of cardiovascular risk factors in the schizophrenia population and the liability some treatments have for their development. These vascular risk factors are in turn important risk factors in the development of demen...
  13. Abnormal indices of cell cycle activity in schizophrenia and their potential association with oligodendrocytes.

    PMID 18322470

    The goal of this study was to determine what signaling pathways may elicit myelin-specific gene expression deficits in schizophrenia (SZ). Microarray analyses indicated that genes associated with canonical cell cycle pathways were significantly affected in the anterior cingulate gyrus (ACG), the...
  14. Abnormal indices of cell cycle activity in schizophrenia and their potential association with oligodendrocytes.

    PMID 18322470

    The goal of this study was to determine what signaling pathways may elicit myelin-specific gene expression deficits in schizophrenia (SZ). Microarray analyses indicated that genes associated with canonical cell cycle pathways were significantly affected in the anterior cingulate gyrus (ACG), the...
  15. Temporal characteristics of tract-specific anisotropy abnormalities in schizophrenia.

    Neuroreport 19(14):1369 (2008) PMID 18766013 PMCID PMC2653858

    White matter abnormalities have been detected using diffusion tensor imaging in a variety of locations in the brains of patients with schizophrenia. Studies that included first-episode patients report less severe or no abnormalities but more pronounced deficits in chronic patients. Here, we inve...
  16. The lobotomist.

    American Journal of Psychiatry 165(4):457 (2008) PMID 18381916

  17. Relationships between white matter metabolite abnormalities, cognitive and social functioning in elderly schizophrenic subjects.

    Schizophrenia Research 100(1-3):356 (2008) PMID 18042350

  18. Relationships between white matter metabolite abnormalities, cognitive and social functioning in elderly schizophrenic subjects.

    Schizophrenia Research 100(1-3):356 (2008) PMID 18042350

  19. Schizophrenia and sex associated differences in the expression of neuronal and oligodendrocyte-specific genes in individual thalamic nuclei.

    Schizophrenia Research 98(1-3):118 (2008) PMID 18029146 PMCID PMC2678297

    Considerable evidence based on the study of postmortem brain tissue suggests deficits in both neuronal and myelin systems in schizophrenia (SZ). To date, the majority of the biochemical and molecular biological studies have focused on the cerebral cortex. Most information traveling to or from th...
  20. Schizophrenia and sex associated differences in the expression of neuronal and oligodendrocyte-specific genes in individual thalamic nuclei.

    Schizophrenia Research 98(1-3):118 (2008) PMID 18029146 PMCID PMC2678297

    Considerable evidence based on the study of postmortem brain tissue suggests deficits in both neuronal and myelin systems in schizophrenia (SZ). To date, the majority of the biochemical and molecular biological studies have focused on the cerebral cortex. Most information traveling to or from th...