A case of placental enlargement in the second trimester
Placenta 36(10):A7 (2015)
The association between placental pathology and neonatal/infantile development
Placenta 36(10):A12 (2015)
Histological characteristics of the myometrium in the postpartum hemorrhage of unknown etiology: a possible involvement of local immune reactions.
Journal of Reproductive Immunology 110:74 (2015)
The aim of this study was to evaluate the histological characteristics of the myometrium obtained in postpartum hemorrhage (PPH) of unknown etiology secondary to uterine atony. These characteristics were selected from among registered cases of clinically suspected amniotic fluid embolism (AFE) a...
Systematic pathological survey of all placentas delivered in a perinatal center
Placenta 35(10):A11 (2014)
C1 esterase inhibitor activity in amniotic fluid embolism.
Critical Care Medicine 42(6):1392 (2014)
Amniotic fluid embolism exhibits activation of the complement system and the kallikrein-kinin and coagulofibrinolytic systems. C1 esterase inhibitor is a major inhibitor of C1 esterase and can inhibit plasma kallikrein and also factors XIIa and XIa. Its activity has been shown to be significantl...
Comparison between placental gene expression of 11β-hydroxysteroid dehydrogenases and infantile growth at 10 months of age.
Journal of obstetrics and gynaecology (Tokyo, J... 40(2):465 (2014)
The local expression of two isoenzymes of 11β-hydroxysteroid dehydrogenase, type 1 (11βHSD-1) and type 2 (11βHSD-2), regulates the access of glucocorticoid hormones to their target cells. Reports on the association between the placental expression of 11βHSD and infantile growth are limited. The ...
Attenuation of fibroblast growth factor signaling by poly-N-acetyllactosamine type glycans.
FEBS Letters 587(19):3195 (2013)
Fibroblast growth factors (FGFs) and their receptors are expressed in a variety of mammalian tissues, playing a role in development and cell proliferation. While analyzing human sperm motility, we found that sperm treated with endo-β-galactosidase (EBG), which specifically hydrolyzes poly-N-acet...
Changes of maternal dietary intake, bodyweight and fetal growth throughout pregnancy in pregnant Japanese women.
Journal of obstetrics and gynaecology (Tokyo, J... 39(9):1383 (2013)
The associations among changes in dietary intake, maternal bodyweight, and fetal growth during the course of pregnancy were investigated in a prospective cohort study carried out on 135 Japanese women.
Dietary intake was analyzed using digital photos of meals taken over 3 consecutive days, in th...
Association between body weight at weaning and remodeling in the subcutaneous adipose tissue of obese adult mice with undernourishment in utero.
Reproductive Sciences 20(7):813 (2013)
Rapid growth in infancy considerably increases the risk of obesity and metabolic disorders in adulthood especially among neonates born small. To investigate the mechanism involved, we developed an animal model of undernourishment in utero by maternal caloric restriction, in which the Z scores of...
Cerebral oxygen saturation evaluated by near-infrared time-resolved spectroscopy (TRS) in pregnant women during caesarean section - a promising new method of maternal monitoring.
Clinical Physiology and Functional Imaging 33(2):109 (2013)
Time-resolved spectroscopy (TRS-20) measures tissue oxygen saturation (%) by evaluating the absolute concentrations of oxygenated, deoxygenated and total haemoglobin based on measurement of the transit time of individual photons through a tissue of interest. We measured tissue oxygen saturation ...
In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse.
Journal of Biological Chemistry 288(7):5007 (2013)
Chst10 adds sulfate to glucuronic acid to form a carbohydrate antigen, HNK-1, in glycoproteins and glycolipids. To determine the role of Chst10 in vivo, we generated systemic Chst10-deficient mutant mice. Although Chst10(-/-) mice were born and grew to adulthood with no gross defects, they were ...
Zinc coproporphyrin I derived from meconium has an antitumor effect associated with singlet oxygen generation.
Fetal Diagnosis and Therapy: clinical advances ... 33(2):90 (2013)
Zinc coproporphyrin I (ZnCP-I) is a photosensitive molecule and a major component of meconium. Here, we examined the effects of ZnCP-I as a potential photosensitizer in photodynamic therapy for tumors.
(1) Aqueous ZnCP-I was irradiated with a pulsed YAG-SHG laser (wavelength: 532 nm)/YAG-SHG dye...
Tumor targeting by a carbohydrate ligand-mimicking peptide.
Methods in Molecular Biology 1022:369 (2013)
Annexin A1 (Anxa1) is a highly specific surface marker of tumor vasculature. We used peptide-displaying phage technology to identify a carbohydrate ligand-mimicking 7-mer peptide, IFLLWQR (IF7), which can target Anxa1 in tumor vasculature. Here, we describe the binding activity of carbohydrate t...
Cell adhesion molecules in human embryo implantation.
Sheng li xue bao : [Acta physiologica Sinica] 64(3):247 (2012)
The process of human embryo implantation is mediated not only by evolutionarily conserved mechanisms, but also by a mechanism unique to humans. Evidence suggests that the cell adhesion molecules, L-selectin and trophinin, play a unique role in human embryo implantation. Here, we describe the dua...
Identification of mono- and disulfated N-acetyl-lactosaminyl Oligosaccharide structures as epitopes specifically recognized by humanized monoclonal antibody HMOCC-1 raised against ovarian cancer.
Journal of Biological Chemistry 287(9):6592 (2012)
A humanized monoclonal antibody raised against human ovarian cancer RMG-I cells and designated as HMOCC-1 (Suzuki, N., Aoki, D., Tamada, Y., Susumu, N., Orikawa, K., Tsukazaki, K., Sakayori, M., Suzuki, A., Fukuchi, T., Mukai, M., Kojima-Aikawa, K., Ishida, I., and Nozawa, S. (2004) Gynecol. Onc...
Reduction in maternal complement levels during delivery by cesarean section.
Journal of obstetrics and gynaecology (Tokyo, J... 38(1):165 (2012)
Primary elective cesarean sections are being carried out in considerable numbers in both developed and developing countries; however, little information is available concerning differences in maternal physiological responses associated with the mode of delivery. The aim of the present study was ...
Successful living donor liver transplantation for fulminant hepatic failure that manifested immediately after cesarean delivery.
ASAIO Journal 58(2):174 (2012)
A 31-year-old pregnant woman was diagnosed as having acute hepatitis of unknown etiology and conservatively treated. An emergency cesarean delivery was performed 5 days later at 33 weeks and 3 days of gestation because of a gradual deterioration in liver function. Two days after the cesarean del...
Enhancement of mouse sperm motility by trophinin-binding peptide.
Reproductive Biology and Endocrinology 10:101 (2012)
Trophinin is an intrinsic membrane protein that forms a complex in the cytoplasm with bystin and tastin, linking it microtubule-associated motor dynein (ATPase) in some cell types. Previously, we found that human sperm tails contain trophinin, bystin and tastin proteins, and that trophinin-bindi...
Trophinin in cell adhesion and signal transduction.
Frontiers in bioscience (elite edition) 4:342 (2012)
The process of human embryo implantation is mediated not only by evolutionarily conserved mechanisms but by activities unique to humans. Among the latter, evidence suggests that the cell adhesion molecule trophinin plays a unique role in human embryo implantation. Here, we describe characteristi...
Carbohydrate mimetic peptides as research reagent and therapeutic.
Biological & Pharmaceutical Bulletin 35(10):1626 (2012)
Although numerous carbohydrates play significant roles in mammalian cells, development of carbohydrate-based reagents and therapeutics are hampered by the technical difficulty of chemically synthesizing complex carbohydrate structures. Use of carbohydrate mimetic peptides circumvents this diffic...