1. Nitroglycerin and Nitric Oxide--A Rondo of Themes in Cardiovascular Therapeutics.

    New England Journal of Medicine 373(3):277 (2015) PMID 26176386

  2. CLINICAL PROBLEM-SOLVING. A Man with Fever, Cough, and Rash.

    New England Journal of Medicine 373(1):74 (2015) PMID 26132944

    A 67-year-old man with hairy-cell leukemia presented to the clinic after 3 days of fevers, night sweats, arthralgias, and an erythematous vesicular-appearing rash on his back. He had not had headache, shortness of breath, bleeding episodes, vomiting, or diarrhea.
  3. Systems medicine: evolution of systems biology from bench to bedside.

    Wiley Interdisciplinary Reviews: Systems Biolog... 7(4):141 (2015) PMID 25891169 PMCID PMC4457580

    High-throughput experimental techniques for generating genomes, transcriptomes, proteomes, metabolomes, and interactomes have provided unprecedented opportunities to interrogate biological systems and human diseases on a global level. Systems biology integrates the mass of heterogeneous high-thr...
  4. Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association.

    Circulation 131(19):1715 (2015) PMID 25882488

    The field of genetics and genomics has advanced considerably with the achievement of recent milestones encompassing the identification of many loci for cardiovascular disease and variable drug responses. Despite this achievement, a gap exists in the understanding and advancement to meaningful tr...
  5. SoNar, a Highly Responsive NAD+/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents.

    Cell Metabolism 21(5):777 (2015) PMID 25955212 PMCID PMC4427571

    The altered metabolism of tumor cells confers a selective advantage for survival and proliferation, and studies have shown that targeting such metabolic shifts may be a useful therapeutic strategy. We developed an intensely fluorescent, rapidly responsive, pH-resistant, genetically encoded senso...
  6. Maintenance of certification: Good intentions gone awry.

    Trends in Cardiovascular Medicine 25(4):312 (2015) PMID 25618320

  7. Nutri(meta)genetics and Cardiovascular Disease: Novel Concepts in the Interaction of Diet and Genomic Variation.

    Current Atherosclerosis Reports 17(5):505 (2015) PMID 25782777 PMCID PMC4401039

    In addition to the interaction of nutrition and genetic variation on the genesis and natural history of cardiovascular disease, recent studies have revealed an entire new genome that resides in the trillions of microbes that exist in various human habitats, predominantly in the gut, that may als...
  8. Genetics and the placebo effect: the placebome.

    Trends in Molecular Medicine 21(5):285 (2015) PMID 25883069

    Placebos are indispensable controls in randomized clinical trials (RCTs), and placebo responses significantly contribute to routine clinical outcomes. Recent neurophysiological studies reveal neurotransmitter pathways that mediate placebo effects. Evidence that genetic variations in these pathwa...
  9. A Man with Diarrhea and Back Pain

    New England Journal of Medicine 372(15):e21 (2015) PMID 25839865

    This interactive feature presents the case of a 43-year-old man with a 6-week history of constant and diffuse abdominal pain and diarrhea six to seven times daily. Test your diagnostic and therapeutic skills at NEJM.org. A 43-year-old man presented with a 6-week history of ab...
  10. A Man with Diarrhea and Back Pain

    New England Journal of Medicine 372(15):e21 (2015) PMID 25853769

    This interactive feature presents the case of a 43-year-old man with a 6-week history of constant and diffuse abdominal pain and diarrhea six to seven times daily. Test your diagnostic and therapeutic skills at NEJM.org. A 43-year-old man presented with a 6-week history of ab...
  11. A Man with Diarrhea and Back Pain

    New England Journal of Medicine 372(15):e21 (2015) PMID 25839865

    This interactive feature presents the case of a 43-year-old man with a 6-week history of constant and diffuse abdominal pain and diarrhea six to seven times daily. Test your diagnostic and therapeutic skills at NEJM.org. A 43-year-old man presented with a 6-week history of ab...
  12. A Man with Diarrhea and Back Pain

    New England Journal of Medicine 372(15):e21 (2015) PMID 25853769

    This interactive feature presents the case of a 43-year-old man with a 6-week history of constant and diffuse abdominal pain and diarrhea six to seven times daily. Test your diagnostic and therapeutic skills at NEJM.org. A 43-year-old man presented with a 6-week history of ab...
  13. A Man with Diarrhea and Back Pain

    New England Journal of Medicine 372(15):e21 (2015) PMID 25853769

    This interactive feature presents the case of a 43-year-old man with a 6-week history of constant and diffuse abdominal pain and diarrhea six to seven times daily. Test your diagnostic and therapeutic skills at NEJM.org. A 43-year-old man presented with a 6-week history of ab...
  14. Response to letters regarding article, "A randomized trial of social media from Circulation".

    Circulation 131(13):e396 (2015) PMID 25825407

  15. Clinical problem solving: Itching for a diagnosis.

    New England Journal of Medicine 372(10):964 (2015) PMID 25738673

    A 58-year-old woman presented with a 2-week history of generalized pruritus. She also reported having fatigue, dizziness, and decreased appetite. A week before the onset of symptoms, a mild upper respiratory tract infection had developed.
  16. Clinical problem solving: Itching for a diagnosis.

    New England Journal of Medicine 372(10):964 (2015) PMID 25738673

    A 58-year-old woman presented with a 2-week history of generalized pruritus. She also reported having fatigue, dizziness, and decreased appetite. A week before the onset of symptoms, a mild upper respiratory tract infection had developed.
  17. Clinical problem solving: Itching for a diagnosis.

    New England Journal of Medicine 372(10):964 (2015) PMID 25738673

    A 58-year-old woman presented with a 2-week history of generalized pruritus. She also reported having fatigue, dizziness, and decreased appetite. A week before the onset of symptoms, a mild upper respiratory tract infection had developed.
  18. Itching for a Diagnosis

    New England Journal of Medicine 372(10):964 (2015) PMID 25738673

    A 58-year-old woman presented with a 2-week history of generalized pruritus. She also reported having fatigue, dizziness, and decreased appetite. A week before the onset of symptoms, a mild upper respiratory tract infection had developed.
  19. Clinical problem solving: Itching for a diagnosis.

    New England Journal of Medicine 372(10):964 (2015) PMID 25738673

    A 58-year-old woman presented with a 2-week history of generalized pruritus. She also reported having fatigue, dizziness, and decreased appetite. A week before the onset of symptoms, a mild upper respiratory tract infection had developed.
  20. Disease networks. Uncovering disease-disease relationships through the incomplete interactome.

    Science 347(6224):1257601 (2015) PMID 25700523 PMCID PMC4435741

    According to the disease module hypothesis, the cellular components associated with a disease segregate in the same neighborhood of the human interactome, the map of biologically relevant molecular interactions. Yet, given the incompleteness of the interactome and the limited knowledge of diseas...