1. Superresolution live imaging of plant cells using structured illumination microscopy.

    Nature Protocols 10(8):1248 (2015) PMID 26203822

    Although superresolution (SR) approaches have been routinely used for fixed or living material from other organisms, the use of time-lapse structured illumination microscopy (SIM) imaging in plant cells still remains under-developed. Here we describe a validated method for time-lapse SIM that fo...
  2. A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer.

    Cell 162(1):146 (2015) PMID 26140595

    KRAS is one of the most frequently mutated oncogenes in human cancer. Despite substantial efforts, no clinically applicable strategy has yet been developed to effectively treat KRAS-mutant tumors. Here, we perform a cell-line-based screen and identify strong synergistic interactions between cell...
  3. Topoisomerase-1 and -2A gene copy numbers are elevated in mismatch repair-proficient colorectal cancers.

    Molecular Oncology 9(6):1207 (2015) PMID 25777966

    Topoisomerase 1 (TOP1) and 2A (TOP2A) are potential predictive biomarkers for irinotecan and anthracycline treatment, respectively, in colorectal cancer (CRC), and we have recently reported a high frequency of gene gain of the TOP1 and TOP2A genes in CRC. Furthermore, Mismatch Repair (MMR) subty...
  4. REV7 counteracts DNA double-strand break resection and affects PARP inhibition.

    Nature 521(7553):541 (2015) PMID 25799992

    Error-free repair of DNA double-strand breaks (DSBs) is achieved by homologous recombination (HR), and BRCA1 is an important factor for this repair pathway. In the absence of BRCA1-mediated HR, the administration of PARP inhibitors induces synthetic lethality of tumour cells of patients with bre...
  5. Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity.

    Oncotarget 6(13):10746 (2015) PMID 25883215 PMCID PMC4484416

    Based on a series of basic, preclinical and clinical studies, the Poly (ADP-ribose) Polymerase 1 (PARP1) inhibitor, olaparib, has recently been approved for use in ovarian cancer patients with BRCA1 or BRCA2 mutations. By identifying novel predictive biomarkers of tumour cell sensitivity to olap...
  6. Predictors of severe complications in intracranial meningioma surgery: a population-based multicenter study.

    World Neurosurgery 83(5):673 (2015) PMID 25655686

    To investigate predictors of complications after intracranial meningioma resection using a standardized reporting system for adverse events. A retrospective review was conducted in a Scandinavian population-based cohort of 979 adult operations for intracranial meningioma performed at 3 neurosurg...
  7. FBH1 Catalyzes Regression of Stalled Replication Forks

    Cell Reports 10(10):1749 (2015)

    DNA replication fork perturbation is a major challenge to the maintenance of genome integrity. It has been suggested that processing of stalled forks might involve fork regression, in which the fork reverses and the two nascent DNA strands anneal. Here, we show that FBH1 catalyzes regr...
  8. Polyethylenimine architecture-dependent metabolic imprints and perturbation of cellular redox homeostasis.

    Biochimica et Biophysica Acta 1848(3):328 (2015) PMID 25482261

    Polyethylenimines (PEIs) are among the most efficient polycationic non-viral transfectants. PEI architecture and size not only modulate transfection efficiency, but also cytotoxicity. However, the underlying mechanisms of PEI-induced multifaceted cell damage and death are largely unknown. Here, ...
  9. Polyethylenimine architecture-dependent metabolic imprints and perturbation of cellular redox homeostasis.

    Biochimica et Biophysica Acta 1848(3):328 (2015) PMID 25482261

    Polyethylenimines (PEIs) are among the most efficient polycationic non-viral transfectants. PEI architecture and size not only modulate transfection efficiency, but also cytotoxicity. However, the underlying mechanisms of PEI-induced multifaceted cell damage and death are largely unknown. Here, ...
  10. Polyethylenimine architecture-dependent metabolic imprints and perturbation of cellular redox homeostasis.

    Biochimica et Biophysica Acta 1848(3):328 (2015) PMID 25482261

    Polyethylenimines (PEIs) are among the most efficient polycationic non-viral transfectants. PEI architecture and size not only modulate transfection efficiency, but also cytotoxicity. However, the underlying mechanisms of PEI-induced multifaceted cell damage and death are largely unknown. Here, ...
  11. Myc and Ras oncogenes engage different energy metabolism programs and evoke distinct patterns of oxidative and DNA replication stress.

    Molecular Oncology 9(3):601 (2015) PMID 25435281

    Both Myc and Ras oncogenes impact cellular metabolism, deregulate redox homeostasis and trigger DNA replication stress (RS) that compromises genomic integrity. However, how are such oncogene-induced effects evoked and temporally related, to what extent are these kinetic parameters shared by Myc ...
  12. Cep63 recruits cdk1 to the centrosome-letter.

    Cancer Research 75(4):777 (2015) PMID 25643699

  13. Cep63 recruits cdk1 to the centrosome-letter.

    Cancer Research 75(4):777 (2015) PMID 25643699

  14. DNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase.

    Cell Cycle 14(3):375 (2015) PMID 25659035

    Death domain-associated protein 6 (DAXX) is a histone chaperone, putative regulator of apoptosis and transcription, and candidate modulator of p53-mediated gene expression following DNA damage. DAXX becomes phosphorylated upon DNA damage, however regulation of this modification, and its relation...
  15. DNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase.

    Cell Cycle 14(3):375 (2015) PMID 25659035

    Death domain-associated protein 6 (DAXX) is a histone chaperone, putative regulator of apoptosis and transcription, and candidate modulator of p53-mediated gene expression following DNA damage. DAXX becomes phosphorylated upon DNA damage, however regulation of this modification, and its relation...
  16. Phosphatidylinositol 3-Kinase (PI3K) and Phosphatidylinositol 3-Kinase-Related Kinase (PIKK) Inhibitors: Importance of the Morpholine Ring.

    Journal of medicinal and pharmaceutical chemistry 58(1):41 (2015) PMID 25387153

    Phosphatidylinositol 3-kinases (PI3Ks) and phosphatidylinositol 3-kinase-related protein kinases (PIKKs) are two related families of kinases that play key roles in regulation of cell proliferation, metabolism, migration, survival, and responses to diverse stresses including DNA damage. To design...
  17. Phosphatidylinositol 3-Kinase (PI3K) and phosphatidylinositol 3-kinase-related kinase (PIKK) inhibitors: importance of the morpholine ring.

    Journal of medicinal and pharmaceutical chemistry 58(1):41 (2015) PMID 25387153

    Phosphatidylinositol 3-kinases (PI3Ks) and phosphatidylinositol 3-kinase-related protein kinases (PIKKs) are two related families of kinases that play key roles in regulation of cell proliferation, metabolism, migration, survival, and responses to diverse stresses including DNA damage. To design...
  18. Phosphatidylinositol 3-Kinase (PI3K) and Phosphatidylinositol 3-Kinase-Related Kinase (PIKK) Inhibitors: Importance of the Morpholine Ring.

    Journal of medicinal and pharmaceutical chemistry 58(1):41 (2015) PMID 25387153

    Phosphatidylinositol 3-kinases (PI3Ks) and phosphatidylinositol 3-kinase-related protein kinases (PIKKs) are two related families of kinases that play key roles in regulation of cell proliferation, metabolism, migration, survival, and responses to diverse stresses including DNA damage. To design...
  19. TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

    Cell 159(6):1476 (2014)

  20. TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

    Cell 159(6):1476 (2014)