1. Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway.

    EMBO Reports 14(4):356 (2013) PMID 23429341 PMCID PMC3615653

    The DNA-binding protein TRF2 is essential for telomere protection and chromosome stability in mammals. We show here that TRF2 expression is activated by the Wnt/β-catenin signalling pathway in human cancer and normal cells as well as in mouse intestinal tissues. Furthermore, β-catenin binds to T...
  2. IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor.

    Molecular and Cellular Biology 33(8):1503 (2013) PMID 23382078 PMCID PMC3624246

    The low-density lipoprotein receptor (LDLR) is a critical determinant of plasma cholesterol levels that internalizes lipoprotein cargo via clathrin-mediated endocytosis. Here, we show that the E3 ubiquitin ligase IDOL stimulates a previously unrecognized, clathrin-independent pathway for LDLR in...
  3. IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor.

    Molecular and Cellular Biology 33(8):1503 (2013) PMID 23382078 PMCID PMC3624246

    The low-density lipoprotein receptor (LDLR) is a critical determinant of plasma cholesterol levels that internalizes lipoprotein cargo via clathrin-mediated endocytosis. Here, we show that the E3 ubiquitin ligase IDOL stimulates a previously unrecognized, clathrin-independent pathway for LDLR in...
  4. Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway.

    EMBO Reports 14(4):356 (2013) PMID 23429341 PMCID PMC3615653

    The DNA-binding protein TRF2 is essential for telomere protection and chromosome stability in mammals. We show here that TRF2 expression is activated by the Wnt/β-catenin signalling pathway in human cancer and normal cells as well as in mouse intestinal tissues. Furthermore, β-catenin binds to T...
  5. Metabolism: Drug discovery goes for a swim.

    Nature Chemical Biology 9(2):68 (2013) PMID 23334543

  6. Metabolism: Drug discovery goes for a swim.

    Nature Chemical Biology 9(2):68 (2013) PMID 23334543

  7. Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells.

    Nature 474(7351):399 (2011) PMID 21602826 PMCID PMC3155806

    The differentiation of patient-derived induced pluripotent stem cells (iPSCs) to committed fates such as neurons, muscle and liver is a powerful approach for understanding key parameters of human development and disease. Whether undifferentiated iPSCs themselves can be used to probe disease mech...
  8. Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells.

    Nature 474(7351):399 (2011) PMID 21602826 PMCID PMC3155806

    The differentiation of patient-derived induced pluripotent stem cells (iPSCs) to committed fates such as neurons, muscle and liver is a powerful approach for understanding key parameters of human development and disease. Whether undifferentiated iPSCs themselves can be used to probe disease mech...
  9. Short telomeres and stem cell exhaustion model Duchenne muscular dystrophy in mdx/mTR mice.

    Cell 143(7):1059 (2010) PMID 21145579 PMCID PMC3025608

    In Duchenne muscular dystrophy (DMD), dystrophin mutation leads to progressive lethal skeletal muscle degeneration. For unknown reasons, dystrophin deficiency does not recapitulate DMD in mice (mdx), which have mild skeletal muscle defects and potent regenerative capacity. We postulated that hum...
  10. Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice

    Cell 143(7):1059 (2010)

    In Duchenne muscular dystrophy (DMD), dystrophin mutation leads to progressive lethal skeletal muscle degeneration. For unknown reasons, dystrophin deficiency does not recapitulate DMD in mice (mdx), which have mild skeletal muscle defects and potent regenerative capacity. We postula...
  11. Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice

    Cell 143(7):1059 (2010) PMID 21145579 PMCID PMC3025608

    In Duchenne muscular dystrophy (DMD), dystrophin mutation leads to progressive lethal skeletal muscle degeneration. For unknown reasons, dystrophin deficiency does not recapitulate DMD in mice (mdx), which have mild skeletal muscle defects and potent regenerative capacity. We postula...
  12. Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice

    Cell 143(7):1059 (2010) PMID 21145579 PMCID PMC3025608

    In Duchenne muscular dystrophy (DMD), dystrophin mutation leads to progressive lethal skeletal muscle degeneration. For unknown reasons, dystrophin deficiency does not recapitulate DMD in mice (mdx), which have mild skeletal muscle defects and potent regenerative capacity. We postula...
  13. Telomerase modulates Wnt signalling by association with target gene chromatin.

    Nature 460(7251):66 (2009) PMID 19571879 PMCID PMC4349391

    Stem cells are controlled, in part, by genetic pathways frequently dysregulated during human tumorigenesis. Either stimulation of Wnt/beta-catenin signalling or overexpression of telomerase is sufficient to activate quiescent epidermal stem cells in vivo, although the mechanisms by which telomer...
  14. Stem Cell Aging and Aberrant Differentiation within the Niche

    Cell Stem Cell 5(1):6 (2009)

    Stem cells age, but the underlying mechanisms remain unclear. In a recent issue of Cell, Inomata and colleagues (2009) show that DNA damage, a prime suspect in stem cell aging, causes graying and loss of melanocyte stem cells by inducing premature differentiation, without inducing apop...
  15. Stem Cell Aging and Aberrant Differentiation within the Niche

    Cell Stem Cell 5(1):6 (2009) PMID 19570507

    Stem cells age, but the underlying mechanisms remain unclear. In a recent issue of Cell, Inomata and colleagues (2009) show that DNA damage, a prime suspect in stem cell aging, causes graying and loss of melanocyte stem cells by inducing premature differentiation, without inducing apop...
  16. Stem cell aging and aberrant differentiation within the niche.

    Cell Stem Cell 5(1):6 (2009) PMID 19570507

    Stem cells age, but the underlying mechanisms remain unclear. In a recent issue of Cell, Inomata and colleagues (2009) show that DNA damage, a prime suspect in stem cell aging, causes graying and loss of melanocyte stem cells by inducing premature differentiation, without inducing apoptosis or s...
  17. Telomerase modulates Wnt signalling by association with target gene chromatin.

    Nature 460(7251):66 (2009) PMID 19571879 PMCID PMC4349391

    Stem cells are controlled, in part, by genetic pathways frequently dysregulated during human tumorigenesis. Either stimulation of Wnt/beta-catenin signalling or overexpression of telomerase is sufficient to activate quiescent epidermal stem cells in vivo, although the mechanisms by which telomer...
  18. Stem Cell Aging and Aberrant Differentiation within the Niche

    Cell Stem Cell 5(1):6 (2009) PMID 19570507

    Stem cells age, but the underlying mechanisms remain unclear. In a recent issue of Cell, Inomata and colleagues (2009) show that DNA damage, a prime suspect in stem cell aging, causes graying and loss of melanocyte stem cells by inducing premature differentiation, without indu...
  19. TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program.

    PLoS Genetics 4(1):e10 (2008) PMID 18208333 PMCID PMC2211538

    Telomerase serves a critical role in stem cell function and tissue homeostasis. This role depends on its ability to synthesize telomere repeats in a manner dependent on the reverse transcriptase (RT) function of its protein component telomerase RT (TERT), as well as on a novel pathway whose mech...
  20. TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program.

    PLoS Genetics 4(1):e10 (2008) PMID 18208333 PMCID PMC2211538

    Telomerase serves a critical role in stem cell function and tissue homeostasis. This role depends on its ability to synthesize telomere repeats in a manner dependent on the reverse transcriptase (RT) function of its protein component telomerase RT (TERT), as well as on a novel pathway whose mech...