1. Hepatic estrogen receptor α improves hepatosteatosis through upregulation of small heterodimer partner.

    Journal of Hepatology 63(1):183 (2015) PMID 25720568

    Estrogen participates in the control of energy homeostasis and lipid metabolism. However the role of hepatic estrogen receptor α (ERα) in triglyceride (TG) homeostasis remains poorly understood. This study aims to investigate the roles of estrogen and ERα in the regulation of hepatic TG metaboli...
  2. Advanced fibrosis associates with atherosclerosis in subjects with nonalcoholic fatty liver disease.

    Atherosclerosis 241(1):145 (2015) PMID 25988358

    Nonalcoholic fatty liver (NAFLD) with advanced fibrosis usually has a deteriorated prognosis, which was mainly attributed to cardiovascular cause. We investigated whether advanced fibrosis assessed by noninvasive fibrosis markers was associated with subclinical atherosclerosis in NAFLD patients....
  3. Afternoon nap and nighttime sleep with risk of micro- and macrovascular disease in middle-aged and elderly population.

    International Journal of Cardiology 187:553 (2015) PMID 25863301

  4. Serum lipoprotein (a) concentrations are inversely associated with T2D, prediabetes, and insulin resistance in a middle-aged and elderly Chinese population.

    Journal of Lipid Research 56(4):920 (2015) PMID 25649924 PMCID PMC4373748

    Lipoprotein (a) [Lp(a)], an LDL-like particle, has been proposed as a causal risk factor for CVD among general populations. Meanwhile, both serum Lp(a) and diabetes increase the risk of CVD. However, the relationship between serum Lp(a) and T2D is poorly characterized, especially in the Asian po...
  5. Status of cardiovascular health in chinese adults.

    Journal of the American College of Cardiology 65(10):1013 (2015) PMID 25766949

    Cardiovascular disease has become the leading cause of death in China. The goal of this study was to evaluate the current status of cardiovascular health in Chinese adults. Cardiovascular health data were collected from a nationally representative sample of 96,121 Chinese adults age ≥20 years in...
  6. Status of Cardiovascular Health in Chinese Adults

    Journal of the American College of Cardiology 65(10):1013 (2015)

    Background Cardiovascular disease has become the leading cause of death in China.
  7. Nesfatin-1 correlates with hypertension in overweight or obese Han Chinese population.

    Clinical and Experimental Hypertension 37(1):51 (2015) PMID 24678977

    Abstract We investigated blood nesfatin-1 levels in hypertension patients. We found that fasting plasma nesfatin-1 levels were significantly higher in hypertension patients than in control groups, especially in overweight/obese hypertension patients (4.5 ± 2.1 versus 3.3 ± 1.1 ng/ml, p < 0.01). ...
  8. Nesfatin-1 correlates with hypertension in overweight or obese Han Chinese population.

    Clinical and Experimental Hypertension 37(1):51 (2015) PMID 24678977

    We investigated blood nesfatin-1 levels in hypertension patients. We found that fasting plasma nesfatin-1 levels were significantly higher in hypertension patients than in control groups, especially in overweight/obese hypertension patients (4.5 ± 2.1 versus 3.3 ± 1.1 ng/ml, p < 0.01). Body mass...
  9. Conditional deletion of Men1 in the pancreatic β-cell leads to glucagon-expressing tumor development.

    Endocrinology 1(1):48 (2015) PMID 25343275

    The tumor suppressor menin is recognized as a key regulator of β-cell proliferation. To induce tumorigenesis within the pancreatic β-cells, floxed alleles of Men1 were selectively ablated using Cre-recombinase driven by the insulin promoter. Despite the β-cell specificity of the RipCre, glucagon...
  10. Conditional deletion of Men1 in the pancreatic β-cell leads to glucagon-expressing tumor development.

    Endocrinology 156(1):48 (2015) PMID 25343275

    The tumor suppressor menin is recognized as a key regulator of β-cell proliferation. To induce tumorigenesis within the pancreatic β-cells, floxed alleles of Men1 were selectively ablated using Cre-recombinase driven by the insulin promoter. Despite the β-cell specificity of the RipCre, glucagon...
  11. Nesfatin-1 correlates with hypertension in overweight or obese Han Chinese population.

    Clinical and Experimental Hypertension 37(1):51 (2015) PMID 24678977

    We investigated blood nesfatin-1 levels in hypertension patients. We found that fasting plasma nesfatin-1 levels were significantly higher in hypertension patients than in control groups, especially in overweight/obese hypertension patients (4.5 ± 2.1 versus 3.3 ± 1.1 ng/ml, p < 0.01). Body mass...
  12. Conditional deletion of Men1 in the pancreatic β-cell leads to glucagon-expressing tumor development.

    Endocrinology 1(1):48 (2015) PMID 25343275

    The tumor suppressor menin is recognized as a key regulator of β-cell proliferation. To induce tumorigenesis within the pancreatic β-cells, floxed alleles of Men1 were selectively ablated using Cre-recombinase driven by the insulin promoter. Despite the β-cell specificity of the RipCre, glucagon...
  13. Awareness, treatment and control of cardiometabolic disorders in Chinese adults with diabetes: a national representative population study.

    Cardiovascular Diabetology 14(1):28 (2015) PMID 25848699 PMCID PMC4356058

    The diagnosis of diabetes has important clinic implications for the prevention and management of cardiometabolic disorders. We aimed to investigate the awareness, treatment and control of hypertension and dyslipidemia in previously-diagnosed and newly-diagnosed diabetes in Chinese adult populati...
  14. Conditional Deletion of Men1 in the Pancreatic β-Cell Leads to Glucagon-Expressing Tumor Development.

    Endocrinology 1(1):48 (2015) PMID 25343275

    The tumor suppressor menin is recognized as a key regulator of β-cell proliferation. To induce tumorigenesis within the pancreatic β-cells, floxed alleles of Men1 were selectively ablated using Cre-recombinase driven by the insulin promoter. Despite the β-cell specificity of the RipCre, glucagon...
  15. Transdifferentiation of pancreatic α-cells into insulin-secreting cells: From experimental models to underlying mechanisms.

    World Journal of Diabetes 5(6):847 (2014) PMID 25512786

    Pancreatic insulin-secreting β-cells are essential regulators of glucose metabolism. New strategies are currently being investigated to create insulin-producing β cells to replace deficient β cells, including the differentiation of either stem or progenitor cells, and the newly uncovered transdi...
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  16. Transdifferentiation of pancreatic α-cells into insulin-secreting cells: From experimental models to underlying mechanisms.

    World Journal of Diabetes 5(6):847 (2014) PMID 25512786 PMCID PMC4265870

    Pancreatic insulin-secreting β-cells are essential regulators of glucose metabolism. New strategies are currently being investigated to create insulin-producing β cells to replace deficient β cells, including the differentiation of either stem or progenitor cells, and the newly uncovered transdi...
  17. Transdifferentiation of pancreatic α-cells into insulin-secreting cells: From experimental models to underlying mechanisms.

    World Journal of Diabetes 5(6):847 (2014) PMID 25512786 PMCID PMC4265870

    Pancreatic insulin-secreting β-cells are essential regulators of glucose metabolism. New strategies are currently being investigated to create insulin-producing β cells to replace deficient β cells, including the differentiation of either stem or progenitor cells, and the newly uncovered transdi...
  18. Plasma ghrelin concentrations are negatively correlated with urine albumin-to-creatinine ratio in newly diagnosed type 2 diabetes.

    American Journal of the Medical Sciences 348(5):382 (2014) PMID 24875659

    Aging is associated with a decrease in appetite, energy intake and glucose tolerance. Experimental studies have suggested that ghrelin and obestatin play a role in glucose homeostasis and in the regulation of energy metabolism. However, few studies have been performed on the role of ghrelin and ...
  19. Plasma ghrelin concentrations are negatively correlated with urine albumin-to-creatinine ratio in newly diagnosed type 2 diabetes.

    American Journal of the Medical Sciences 348(5):382 (2014) PMID 24875659

    Aging is associated with a decrease in appetite, energy intake and glucose tolerance. Experimental studies have suggested that ghrelin and obestatin play a role in glucose homeostasis and in the regulation of energy metabolism. However, few studies have been performed on the role of ghrelin and ...
  20. Plasma ghrelin concentrations are negatively correlated with urine albumin-to-creatinine ratio in newly diagnosed type 2 diabetes.

    American Journal of the Medical Sciences 348(5):382 (2014) PMID 24875659

    Aging is associated with a decrease in appetite, energy intake and glucose tolerance. Experimental studies have suggested that ghrelin and obestatin play a role in glucose homeostasis and in the regulation of energy metabolism. However, few studies have been performed on the role of ghrelin and ...