The influence of flavonoid amendment on the absorption of cadmium in Avicennia marina roots.
Ecotoxicology and Environmental Safety 120:1 (2015)
Flavonoid is a key factor for the tolerance to cadmium in plants. Concentration-dependent kinetics experiment was conducted to investigate the influence of flavonoid amendment on the Cd(2+) uptake in Avicennia marina (Forsk) Vierh. roots. We found that compared with the control, saturation conce...
A novel two-dimensional liquid chromatographic system for the online toxicity prediction of pharmaceuticals and related substances.
Journal of Hazardous Materials 293:15 (2015)
In this study, a novel two-dimensional liquid chromatographic (2D-LC) system was developed for simultaneous separation and toxicity prediction of pharmaceutical and its related substances. A conventional ODS column was used on the 1st-D to separate the sample; while, bio-partitioning micellar ch...
Identification of a novel FGFRL1 MicroRNA target site polymorphism for bone mineral density in meta-analyses of genome-wide association studies.
Human Molecular Genetics 24(16):4710 (2015)
MicroRNAs (miRNAs) are critical post-transcriptional regulators. Based on a previous genome-wide association (GWA) scan, we conducted a polymorphism in microRNA target sites (poly-miRTS)-centric multistage meta-analysis for lumbar spine (LS)-, total hip (HIP)- and femoral neck (FN)-bone mineral ...
Therapeutic effects of Lactobacillus casei Qian treatment in activated carbon‑induced constipated mice.
Molecular Medicine Reports 12(2):3191 (2015)
In the present study, the therapeutic effects of Lactobacillus casei Qian (LC‑Qian), the key microorganism in Tibetan yak yoghurt, on activated carbon‑induced constipation were determined in vivo. ICR mice were treated with LC‑Qian for nine days by oral administration. The body weight, defecatio...
Characterization of the subsets of human NKT-like cells and the expression of Th1/Th2 cytokines in patients with unexplained recurrent spontaneous abortion.
Journal of Reproductive Immunology 110:81 (2015)
The objective was to investigate the subsets of natural killer T (NKT)-like cells and the expression of Th1/Th2 cytokines in the peripheral blood (PB) and/or decidual tissue of patients with unexplained recurrent spontaneous abortion (URSA). The percentages of NKT-like cells in the PB and decidu...
Reliability of a new 4th generation FloTrac algorithm to track cardiac output changes in patients receiving phenylephrine.
Journal of Clinical Monitoring and Computing 29(4):467 (2015)
Phenylephrine is often used to treat intra-operative hypotension. Previous studies have shown that the FloTrac cardiac monitor may overestimate cardiac output (CO) changes following phenylephrine administration. A new algorithm (4th generation) has been developed to improve performance in this s...
A novel two-dimensional liquid-chromatography method for online prediction of the toxicity of transformation products of benzophenones after water chlorination.
Analytical and Bioanalytical Chemistry 407(20):6137 (2015)
Benzophenone-type UV filters (BPs) are ubiquitous in the environment. Transformation products (TPs) of BPs with suspected toxicity are likely to be produced during disinfection of water by chlorination. To quickly predict the toxicity of TPs, in this study, a novel two-dimensional liquid-chromat...
Transcriptome and MassARRAY analysis for identification of transcripts and SNPs for growth traits of the swimming crab Portunus trituberculatus.
Gene 566(2):229 (2015)
Portunus trituberculatus is an important farmed crustacean in China. Growth traits are important economic traits that are controlled by many genes. The aim of this study was to screen growth-related genes using Illumina paired-end sequencing technology, and to identify growth-related SNPs in P. ...
[Quercetin protects against lipopolysaccharide-induced cardiac injury in mice].
Nan fang yi ke da xue xue bao = Journal of Sout... 35(7):1068 (2015)
To evaluate the protective effect of quercetin against lipopolysaccharide (LPS)-induced cardiac injury in mice.
C57BL/6J mice were randomized into 4 groups to receive intraperitoneal injection of saline (negative control) or LPS (20 mg/kg), or fed with quercetin (100 mg/kg for 7 days) with or wi...
Michael acceptor in gambogic acid-Its role and application for potent antitumor agents.
Bioorganic & Medicinal Chemistry Letters 25(14):2844 (2015)
Gambogic acid (GA), a natural product with unique structure, was reported to have broad antiproliferation activities against cancer cell lines. As a reactive Michael acceptor, the 10-position of GA is susceptible to nucleophiles, thus limiting its clinical application as an anticancer agent. Mor...
Linear optical demonstration of quantum speed-up with a single qudit.
Optics Express 23(14):18422 (2015)
Quantum algorithm acts as an important role in quantum computation science, not only for providing a great vision for solving classically unsolvable problems, but also due to the fact that it gives a potential way of understanding quantum physics. We experimentally realize a quantum speed-up alg...
A-site-deficiency facilitated in situ growth of bimetallic Ni-Fe nano-alloys: a novel coking-tolerant fuel cell anode catalyst.
Nanoscale 7(25):11173 (2015)
To date, most investigations of Ni-Fe bimetallic catalysts for solid oxide fuel cells (SOFCs) have focused on materials with micro-scale particle sizes, which severely restrict their catalytic activity. In this study, we fabricated a Ni- and/or Fe-doped A-site-deficient LaSrCrO3 perovskite (A-LS...
Personality and risk of adult asthma in a prospective cohort study.
Journal of Psychosomatic Research 79(1):13 (2015)
Traits conceptualized according to the five-factor model of personality have been found to predict numerous health outcomes and may also be predictive of asthma. Prior longitudinal studies on personality and asthma remain however sparse, have been restricted to only two traits (i.e., neuroticism...
Design, Synthesis, and Biological Evaluation of Novel Nonsteroidal Farnesoid X Receptor (FXR) Antagonists: Molecular Basis of FXR Antagonism.
Chemmedchem 10(7):1184 (2015)
Farnesoid X receptor (FXR) plays an important role in the regulation of cholesterol, lipid, and glucose metabolism. Recently, several studies on the molecular basis of FXR antagonism have been reported. However, none of these studies employs an FXR antagonist with nonsteroidal scaffold. On the b...
Discovery of Benzylidene Derivatives as Potent Syk Inhibitors: Synthesis, SAR Analysis, and Biological Evaluation.
Archiv der Pharmazie (Weinheim) 348(7):463 (2015)
Four scaffolds of varied benzylidene derivatives were synthesized and evaluated as Syk inhibitors for the treatment of rheumatoid arthritis (RA). Among these 31 compounds, 3-benzylidene pyrrolidine-2,5-dione derivatives (including 12k) universally showed good Syk inhibitory activities in the low...
Fish Oil and Olive Oil Supplementation in Late Pregnancy and Lactation Differentially Affect Oxidative Stress and Inflammation in Sows and Piglets.
Lipids 50(7):647 (2015)
This study was conducted to compare the effects of fish oil and olive oil supplementation in late pregnancy and during lactation on oxidative stress and inflammation in sows and their piglets. A total of 24 sows were fed a basal diet supplemented with additional corn starch (CON), fish oil (FO) ...
Nitinol stents loaded with a high dose of antitumor 5-fluorouracil or paclitaxel: esophageal tissue responses in a porcine model.
Gastrointestinal Endoscopy 82(1):153 (2015)
A poor prognosis associated with esophageal cancer leads to surgical resection not suitable for most patients. Nitinol stents loaded with 50% 5-fluorouracil (5-FU) or paclitaxel (PTX), functioning both as a stent and local chemotherapy, could provide a new therapy modality for these patients.
[Risk factors for extrauterine growth retardation at discharge in premature infants].
Zhongguo dang dai er ke za zhi = Chinese journa... 17(7):659 (2015)
To study the incidence and risk factors for extrauterine growth retardation (EUGR) at discharge in premature infants.
A retrospective analysis was performed on 596 premature infants who were admitted to the neonatal intensive care unit between 2006 and 2010. These subjects were classified into E...
Phagocytosis of platelets enhances endothelial cell survival under serum deprivation.
Experimental Biology and Medicine 240(7):876 (2015)
Platelets are key players in fundamental processes of vascular biology, such as angiogenesis, tissue regeneration, and tumor metastasis. However, the underlying mechanisms remain unclear. In this study, some tumor vascular endothelial cells were positively stained by antiplatelet antibodies. Fur...
Structure determination of two new bisabolane-type sesquiterpenes from the rhizomes of Curcuma longa by NMR spectroscopy.
Organic Magnetic Resonance 53(7):536 (2015)