Principal components analysis of agitation outcomes in Alzheimer's disease.
Journal of Psychiatric Research 79:4 (2016)
We developed a composite measure of agitation as a secondary outcome of change over time in the Citalopram for Agitation in Alzheimer's disease study (CitAD). CitAD demonstrated a positive effect of citalopram on agitation on the Neurobehavioral Rating Scale agitation subscale (NBRS-A). CitAD in...
Sedation mediates part of Citalopram's effect on agitation in Alzheimer's disease.
Journal of Psychiatric Research 74:17 (2016)
We found a benefit of citalopram for agitation in the Citalopram for Agitation in Alzheimer's Disease study (CitAD), and wondered if this was mediated by a sedative effect. CitAD was a randomized, placebo-controlled, double-blind, parallel group trial conducted at 8 academic centers in the Unite...
Ubiquity of Undiagnosed Sleep Disordered Breathing in Community-Dwelling Older Male Veterans.
American Journal of Geriatric Psychiatry 24(2):170 (2016)
To determine the point prevalence of sleep disordered breathing (SDB) in a community-based sample of older male veterans and to determine if common markers of SDB apply to this population.
Two hundred fourteen older male Veterans (age 55-89 years) were recruited for a study on post-traumatic str...
Donepezil treatment in ethnically diverse patients with Alzheimer disease.
American Journal of Geriatric Psychiatry 23(4):384 (2015)
To compare the outcome of donepezil treatment in ethnically diverse Alzheimer disease (AD) patients with ethnically diverse AD patients who did not receive donepezil.
Patients meeting NINCDS-ADRA criteria for probable or possible AD from a consortium of California sites were systematically follo...
The impact of depression on Veterans with PTSD and traumatic brain injury: a diffusion tensor imaging study.
Biological Psychology 105:20 (2015)
A significant proportion of military personnel deployed in support of Operation Enduring Freedom and Operation Iraqi Freedom were exposed to war-zone events associated with traumatic brain injury (TBI), depression (DEP) and posttraumatic stress disorder (PTSD). The co-occurrence of TBI, PTSD and...
Nocturia reported in nightly sleep diaries: common occurrence with significant implications?
Health Psychology 33(11):1362 (2014)
Nocturia (nocturnal awakenings associated with urination) is so common a nocturnal behavior that its association with poor sleep is often overlooked. This study examined nocturia and its potential role in poor sleep by examining reported nightly awakenings and associated bathroom trips.
Longitudinal assessment of sleep disordered breathing in Vietnam veterans with post-traumatic stress disorder.
Nature and Science of Sleep 6:123 (2014)
Previous work has demonstrated the relatively high prevalence of risk factors for cognitive impairment, such as sleep disordered breathing (SDB) and obesity, in Vietnam War era veterans with post-traumatic stress disorder (PTSD). No data are currently available on the longitudinal stability of S...
Effects of body mass index-related disorders on cognition: preliminary results.
Diabetes Metabolic Syndrome and Obesity Targets... 7:145 (2014)
Well-known risk factors for cognitive impairment are also associated with obesity. Research has highlighted genetic risk factors for obesity, yet the relationship of those risk factors with cognitive impairment is unknown. The objective of this study was to determine the associations between cog...
Higher landing accuracy in expert pilots is associated with lower activity in the caudate nucleus.
PLoS ONE 9(11):e112607 (2014)
The most common lethal accidents in General Aviation are caused by improperly executed landing approaches in which a pilot descends below the minimum safe altitude without proper visual references. To understand how expertise might reduce such erroneous decision-making, we examined relevant neur...
Phenotyping apathy in individuals with Alzheimer disease using functional principal component analysis.
American Journal of Geriatric Psychiatry 21(4):391 (2013)
To determine if there is a specific pattern of gross motor activity associated with apathy in individuals with Alzheimer disease (AD).
Examination of ad libitum 24-hour ambulatory gross motor activity patterns.
Ninety-two individuals with AD, 35 of whom had apathy...
Nocturia compounds nocturnal wakefulness in older individuals with insomnia.
Journal of clinical sleep medicine : JCSM : off... 9(3):259 (2013)
To determine the impact of nocturia on objective measures of sleep in older individuals with insomnia.
The sleep and toileting patterns of a group of community-dwelling older men (n = 55, aged 64.3 ± 7.52 years) and women (n = 92, aged 62.5 ± 6.73 years) with insomnia were studied for two weeks ...
Memantine is associated with longer survival than donepezil in a Veterans Affairs prescription database, 1997 to 2008.
Journal of Alzheimer's Disease 36(4):791 (2013)
Alzheimer's disease (AD) shortens life-expectancy, but the effects of pharmacological treatments for this disorder on mortality have not been studied. We compared two commonly prescribed medications, donepezil and memantine, with respect to the length of survival of veterans presumed to have AD....
Modeling the effects of obstructive sleep apnea and hypertension in Vietnam veterans with PTSD.
Sleep and Breathing 16(4):1201 (2012)
The present work aimed to extend models suggesting that obstructive sleep apnea (OSA) is associated with worse cognitive performance in community-dwelling older adults. We hypothesized that in addition to indices of OSA severity, hypertension is associated with worse cognitive performance in suc...
Decreased daytime motor activity associated with apathy in Alzheimer disease: an actigraphic study.
American Journal of Geriatric Psychiatry 20(9):806 (2012)
Across all stages of Alzheimer disease (AD), apathy is the most common neuropsychiatric symptom. Studies using the Neuropsychiatric Inventory (NPI) have found that apathy is present in up to 70% of individuals with Alzheimer disease. One of the main difficulties in assessing apathy and other neu...
Pilot expertise and hippocampal size: associations with longitudinal flight simulator performance.
Aviation, Space, and Environmental Medicine 83(9):850 (2012)
Previous research suggests that the size of the hippocampus can vary in response to intensive training (e.g., during the acquisition of expert knowledge). However, the role of the hippocampus in maintenance of skilled performance is not well understood. The Stanford/Veterans Affairs Aviation MRI...
Brief morning light treatment for sleep/wake disturbances in older memory-impaired individuals and their caregivers.
Sleep Medicine 13(5):546 (2012)
Scheduled exposure to bright light (phototherapy) has been used, with varying degrees of success, to treat sleep disruption in older individuals. Most of these studies have been done in institutional settings and have used several hours of daily light exposure. Such a regimen in the home setting...
Sleep-disordered breathing in Vietnam veterans with posttraumatic stress disorder.
American Journal of Geriatric Psychiatry 20(3):199 (2012)
: To study the prevalence of sleep-disordered breathing (SDB) in Vietnam- era veterans.
: This was an observational study of Vietnam-era veterans using unattended, overnight polysomnography, cognitive testing, and genetic measures.
: A sample of 105 Vietnam-era veterans with posttraumatic stress...
Delineating a Retesting Zone Using Receiver Operating Characteristic Analysis on Serial QuantiFERON Tuberculosis Test Results in US Healthcare Workers.
Pulmonary Medicine 2012:291294 (2012)
Objective. To find a statistically significant separation point for the QuantiFERON Gold In-Tube (QFT) interferon gamma release assay that could define an optimal "retesting zone" for use in serially tested low-risk populations who have test "reversions" from initially positive to subsequently n...
Effectiveness of evening phototherapy for insomnia is reduced by bright daytime light exposure.
Sleep Medicine 12(8):805 (2011)
To examine the effect of ambulatory daytime light exposure on phase delays and on the advances produced by timed exposure to bright evening or morning light.
As a subset of a larger study, 32 older (63.0 ± 6.43 years) adults with primary insomnia were randomized to an at-home, single-blind, 12-w...
Initial cognitive performance predicts longitudinal aviator performance.
Journals of Gerontology Series B: Psychological... 66(4):444 (2011)
The goal of the study was to improve prediction of longitudinal flight simulator performance by studying cognitive factors that may moderate the influence of chronological age.
We examined age-related change in aviation performance in aircraft pilots in relation to baseline cognitive ability mea...