Prefrontal Transcranial Direct Current Stimulation for Treatment of Schizophrenia With Predominant Negative Symptoms: A Double-Blind, Sham-Controlled Proof-of-Concept Study.
Schizophrenia Bulletin 42(5):1253 (2016)
Negative symptoms are highly relevant in the long-term course of schizophrenia and are an important target domain for the development of novel interventions. Recently, transcranial direct current stimulation (tDCS) of the prefrontal cortex has been investigated as a treatment option in schizophr...
Functional connectivity increase in the default-mode network of patients with Alzheimer's disease after long-term treatment with Galantamine.
European Neuropsychopharmacology 26(3):602 (2016)
Acetylcholinesterase inhibitors (AChEIs) are efficacious for the treatment of mild to moderate forms of Alzheimer's dementia (AD). Default-mode network (DMN) connectivity is considered to be early impaired in AD. Long-term effects of AChEIs on the DMN in AD have not yet been investigated. Twenty...
Synchronization as a biological, psychological and social mechanism to create common time: A theoretical frame and a single case study.
PsyCh Journal 4(4):243 (2015)
Synchronizing neural processes, mental activities, and social interactions is considered to be fundamental for the creation of temporal order on the personal and interpersonal level. Several different types of synchronization are distinguished, and for each of them examples are given: self-organ...
Does a bishop pray when he prays? And does his brain distinguish between different religions?
PsyCh Journal 4(4):199 (2015)
Does a religion shape belief-related decisions and influence neural processing? We investigated an eminent bishop of the Catholic Church in Germany by using functional magnetic resonance imaging (fMRI) to assess neural processing while he was responding to short sentences of the Christian Bible,...
Resting-state networks in healthy adult subjects: a comparison between a 32-element and an 8-element phased array head coil at 3.0 Tesla.
Acta Radiologica 56(5):605 (2015)
Little research exists on the influence of a magnetic resonance imaging (MRI) head coil's channel count on measured resting-state functional connectivity.
To compare a 32-element (32ch) and an 8-element (8ch) phased array head coil with respect to their potential to detect functional connectivit...
Compassion, guilt and innocence: An fMRI study of responses to victims who are responsible for their fate.
Social Neuroscience 10(3):243 (2015)
Compassion is a human feeling towards an individual who is suffering. However, the responses toward a victim are not always compassionate and may, for example, be moderated by the perceived responsibility of the victim. In the present study, we investigated the neural correlates of compassion an...
Modulation of Craving Related Brain Responses Using Real-Time fMRI in Patients with Alcohol Use Disorder.
PLoS ONE 10(7):e0133034 (2015)
One prominent symptom in addiction disorders is the strong desire to consume a particular substance or to display a certain behaviour (craving). Especially the strong association between craving and the probability of relapse emphasises the importance of craving in the therapeutic process. Neuro...
Neurofunctional correlates of environmental cognition: an FMRI study with images from episodic memory.
PLoS ONE 10(4):e0122470 (2015)
This study capitalizes on individual episodic memories to investigate the question, how dif-ferent environments affect us on a neural level. Instead of using predefined environmental stimuli, this study relied on individual representations of beauty and pleasure. Drawing upon episodic memories w...
Dysregulated daily rhythmicity of neuronal resting-state networks in MCI patients.
Chronobiology International 31(9):1041 (2014)
In young healthy participants, the degree of daily rhythmicity largely varies across different neuronal resting-state networks (RSNs), while it is to date unknown whether this temporal pattern of activity is conserved in healthy and pathological aging. Twelve healthy elderly (mean age=65.1±5.7 y...
Existential neuroscience: effects of mortality salience on the neurocognitive processing of attractive opposite-sex faces.
Social Cognitive and Affective Neuroscience 9(10):1601 (2014)
Being reminded of the inherently finite nature of human existence has been demonstrated to elicit strivings for sexual reproduction and the formation and maintenance of intimate relationships. Recently, it has been proposed that the perception of potential mating partners is influenced by mortal...
Differences between musicians and non-musicians in neuro-affective processing of sadness and fear expressed in music
Neuroscience Letters 566:120 (2014)
Musicians rate “negative” emotions expressed in music as more arousing.
For sadness, musicians show higher activation in the right prefrontal cortex.
An open science resource for establishing reliability and reproducibility in functional connectomics.
Scientific data 1:140049 (2014)
Efforts to identify meaningful functional imaging-based biomarkers are limited by the ability to reliably characterize inter-individual differences in human brain function. Although a growing number of connectomics-based measures are reported to have moderate to high test-retest reliability, the...
Sadness is unique: neural processing of emotions in speech prosody in musicians and non-musicians.
Frontiers in Human Neuroscience 8:1049 (2014)
Musical training has been shown to have positive effects on several aspects of speech processing, however, the effects of musical training on the neural processing of speech prosody conveying distinct emotions are yet to be better understood. We used functional magnetic resonance imaging (fMRI) ...
Neural correlates of moral judgments in first- and third-person perspectives: implications for neuroethics and beyond.
BMC Neuroscience 15:39 (2014)
There appears to be an inconsistency in experimental paradigms used in fMRI research on moral judgments. As stimuli, moral dilemmas or moral statements/ pictures that induce emotional reactions are usually employed; a main difference between these stimuli is the perspective of the participants r...
Prefrontal transcranial direct current stimulation (tDCS) changes negative symptoms and functional connectivity MRI (fcMRI) in a single case of treatment-resistant schizophrenia.
Schizophrenia Research 150(2-3):583 (2013)
Classifying fMRI-derived resting-state connectivity patterns according to their daily rhythmicity.
NeuroImage 71:298 (2013)
The vast majority of biological functions express rhythmic fluctuations across the 24-hour day. We investigated the degree of daily modulation across fMRI (functional Magnetic Resonance Imaging) derived resting-state data in 15 subjects by evaluating the time courses of 20 connectivity patterns ...
Neurofunctional correlates of esthetic and moral judgments.
Neuroscience Letters 534:128 (2013)
Recent neuroimaging studies indicate that there may be common ground for esthetic and moral judgments. However, because previous studies focused on either esthetic or moral judgments and did not compare the two directly, the issue remains open whether a common ground actually exists. We employed...
Convergent Findings of Altered Functional and Structural Brain Connectivity in Individuals with High Functioning Autism: A Multimodal MRI Study.
PLoS ONE 8(6):e67329 (2013)
Brain tissue changes in autism spectrum disorders seem to be rather subtle and widespread than anatomically distinct. Therefore a multimodal, whole brain imaging technique appears to be an appropriate approach to investigate whether alterations in white and gray matter integrity relate to consis...
Long-term test-retest reliability of resting-state networks in healthy elderly subjects and with amnestic mild cognitive impairment patients.
Journal of Alzheimer's Disease 34(3):741 (2013)
The investigation of cerebral resting-state networks (RSNs) by functional magnetic resonance imaging (fMRI) is a promising tool for the early diagnosis and follow-up of neuropsychiatric and neurodegenerative disorders like Alzheimer's disease (AD). In this context, the determination of inter-ses...
Self processing in the brain: A paradigmatic fMRI case study with a professional singer
Brain and Cognition 87 (2012)
Understanding the mechanisms involved in perception and conception of oneself is a fundamental psychological topic with high relevance for psychiatric and neurological issues, and it is one of the great challenges in neuroscientific research. The paradigmatic single-case study presente...