Relaxation and exchange dynamics of hyperpolarized 129Xe in human blood.
Magnetic Resonance in Medicine 74(2):303 (2015)
(129) Xe-blood NMR was performed over the full blood oxygenation range to evaluate (129) Xe relaxation and exchange dynamics in human blood.
Hyperpolarized (129) Xe was equilibrated with blood and isolated plasma, and NMR was performed at 1.5 T.
The (129) Xe relaxation rate was found to increase...
Quantitative analysis of hyperpolarized 129Xe ventilation imaging in healthy volunteers and subjects with chronic obstructive pulmonary disease.
NMR in Biomedicine 26(4):424 (2013)
In this study, hyperpolarized (129) Xe MR ventilation and (1) H anatomical images were obtained from three subject groups: young healthy volunteers (HVs), subjects with chronic obstructive pulmonary disease (COPD) and age-matched controls (AMCs). Ventilation images were quantified by two methods...
Direct visualisation of collateral ventilation in COPD with hyperpolarised gas MRI.
Thorax 67(7):613 (2012)
Collateral ventilation has been proposed as a mechanism of compensation of respiratory function in obstructive lung diseases but observations of it in vivo are limited. The assessment of collateral ventilation with an imaging technique might help to gain insight into lung physiology and assist t...
Chronic obstructive pulmonary disease: safety and tolerability of hyperpolarized 129Xe MR imaging in healthy volunteers and patients.
Radiology 262(1):279 (2012)
To evaluate the safety and tolerability of inhaling multiple 1-L volumes of undiluted hyperpolarized xenon 129 ((129)Xe) followed by up to a 16-second breath hold and magnetic resonance (MR) imaging.
This study was approved by the institutional review board and was HIPAA compliant. Written infor...
Diffusion-weighted hyperpolarized 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease.
Magnetic Resonance in Medicine 65(4):1154 (2011)
Given its greater availability and lower cost, (129) Xe apparent diffusion coefficient (ADC) MRI offers an alternative to (3) He ADC MRI. To demonstrate the feasibility of hyperpolarized (129) Xe ADC MRI, we present results from healthy volunteers (HV), chronic obstructive pulmonary disease (COP...
Applications of hyperpolarized agents in solutions.
Methods in Molecular Biology 771:655 (2011)
This chapter provides an overview of pulse sequences adapted to hyperpolarized MR imaging. Applications of hyperpolarized agents in aqueous solution are reviewed. Vascular (e.g., angiography, perfusion, and catheter tracking) as well as metabolic (e.g., oncology, cardiology, neurology, and pH ma...
Hyperpolarized molecules in solution.
Methods in Molecular Biology 771:205 (2011)
Hyperpolarization is a technique to enhance the nuclear polarization and thereby increase the available signal in magnetic resonance (MR). This chapter provides an introduction to the concept of hyperpolarization as well as an overview of dynamic nuclear polarization (DNP) and para-hydrogen indu...
Hyperpolarized Xe MR imaging of alveolar gas uptake in humans.
PLoS ONE 5(8):e12192 (2010)
One of the central physiological functions of the lungs is to transfer inhaled gases from the alveoli to pulmonary capillary blood. However, current measures of alveolar gas uptake provide only global information and thus lack the sensitivity and specificity needed to account for regional variat...
Relationship between structural changes and hyperpolarized gas magnetic resonance imaging in chronic obstructive pulmonary disease using computational simulations with realistic alveolar geometry.
Philosophical Transactions of the Royal Society... 367(1896):2347 (2009)
Both the development of accurate models of lung function and their quantitative validation can be significantly enhanced by the use of functional imaging techniques. The advent of hyperpolarized noble gas magnetic resonance imaging (MRI) technology has increased the amount of local, functional i...
Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.
Nature Medicine 13(11):1382 (2007)
Measurements of early tumor responses to therapy have been shown, in some cases, to predict treatment outcome. We show in lymphoma-bearing mice injected intravenously with hyperpolarized [1-(13)C]pyruvate that the lactate dehydrogenase-catalyzed flux of (13)C label between the carboxyl groups of...
Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccaride disease model using hyperpolarized 129Xe.
Magnetic Resonance in Medicine 50(6):1170 (2003)
The ability to quantify pulmonary diffusing capacity and perfusion using dynamic hyperpolarized (129)Xe NMR spectroscopy is demonstrated. A model of alveolar gas exchange was developed, which, in conjunction with (129)Xe NMR, enables quantification of average alveolar wall thickness, pulmonary p...
Increase of signal-to-noise of more than 10,000 times in liquid state NMR.
Discovery medicine 3(19):37 (2003)
Extract: Two major applications exist for Nuclear Magnetic Resonance (NMR): spectroscopy and imaging. NMR spectroscopy has gained acceptance as one of the major analytical techniques, due to the detailed information that can be obtained about molecular structure, dynamics and intra- and inter-mo...
Diffusion MRI for prediction of response of rectal cancer to chemoradiation.
The Lancet 360(9329):307 (2002)
Prediction of tumour response before onset of treatment could have considerable clinical benefit. Since the apparent diffusion coefficient (ADC) of a tumour's water content can show the extent of necrosis, we looked for a possible correlation of ADC with response to treatment. We measured mean t...
Diffusion MRI for prediction of response of rectal cancer to chemoradiation
The Lancet 360(9329):307 (2002)
Prediction of tumour response before onset of treatment could have considerable clinical benefit. Since the apparent diffusion coefficient (ADC) of a tumour's water content can show the extent of necrosis, we looked for a possible correlation of ADC with response to treatment. We measured m...
Measuring diffusion of xenon in solution with hyperpolarized129Xe NMR
Chemical Physics Letters 296(3):391 (1998)
Xe Nuclear Magnetic Resonance (NMR) technique for measuring diffusion of xenon in solution is presented. The dramatically enhanced NMR signal of hyperpolarized
Xe makes it possible to measure the xenon self-diffusion coeffic...