1. Molecular imaging of prostate cancer: translating molecular biology approaches into the clinical realm.

    European Radiology 25(5):1294 (2015) PMID 25693661

    The epidemiology of prostate cancer has dramatically changed since the introduction of prostate-specific antigen (PSA) screening in the 1980's. Most prostate cancers today are detected at early stages of the disease and are considered 'indolent'; however, some patients' prostate cancers demonstr...
  2. Cerenkov Luminescence Imaging for Radiation Dose Calculation of a ⁹⁰Y-Labeled Gastrin-Releasing Peptide Receptor Antagonist.

    Journal of nuclear medicine : official publicat... 56(5):805 (2015) PMID 25840974 PMCID PMC4470706

    (90)Y has been used to label various new therapeutic radiopharmaceuticals. However, measuring the radiation dose delivered by (90)Y is challenging because of the absence of suitable γ emissions and its low abundance of positron emissions. For the treatment of prostate cancer, radiolabeled gastri...
  3. Cancer nanomedicine: Therapy from within.

    Nature Nanotechnology 10(4):299 (2015) PMID 25855256

  4. Silica Nanoparticles as Substrates for Chelator-free Labeling of Oxophilic Radioisotopes.

    Nano Letters 15(2):864 (2015) PMID 25559467

    Chelator-free nanoparticles for intrinsic radiolabeling are highly desirable for whole-body imaging and therapeutic applications. Several reports have successfully demonstrated the principle of intrinsic radiolabeling. However, the work done to date has suffered from much of the same specificity...
  5. Silica Nanoparticles as Substrates for Chelator-free Labeling of Oxophilic Radioisotopes.

    Nano Letters 15(2):864 (2015) PMID 25559467

    Chelator-free nanoparticles for intrinsic radiolabeling are highly desirable for whole-body imaging and therapeutic applications. Several reports have successfully demonstrated the principle of intrinsic radiolabeling. However, the work done to date has suffered from much of the same specificity...
  6. Silica Nanoparticles as Substrates for Chelator-free Labeling of Oxophilic Radioisotopes.

    Nano Letters 15(2):864 (2015) PMID 25559467

    Chelator-free nanoparticles for intrinsic radiolabeling are highly desirable for whole-body imaging and therapeutic applications. Several reports have successfully demonstrated the principle of intrinsic radiolabeling. However, the work done to date has suffered from much of the same specificity...
  7. Nanoparticles for imaging: top or flop?

    Radiology 273(1):10 (2014) PMID 25247562 PMCID PMC4186876

    Nanoparticles are frequently suggested as diagnostic agents. However, except for iron oxide nanoparticles, diagnostic nanoparticles have been barely incorporated into clinical use so far. This is predominantly due to difficulties in achieving acceptable pharmacokinetic properties and reproducibl...
  8. Nanoparticles for imaging: top or flop?

    Radiology 273(1):10 (2014) PMID 25247562 PMCID PMC4186876

    Nanoparticles are frequently suggested as diagnostic agents. However, except for iron oxide nanoparticles, diagnostic nanoparticles have been barely incorporated into clinical use so far. This is predominantly due to difficulties in achieving acceptable pharmacokinetic properties and reproducibl...
  9. Nanoparticles for imaging: top or flop?

    Radiology 273(1):10 (2014) PMID 25247562 PMCID PMC4186876

    Nanoparticles are frequently suggested as diagnostic agents. However, except for iron oxide nanoparticles, diagnostic nanoparticles have been barely incorporated into clinical use so far. This is predominantly due to difficulties in achieving acceptable pharmacokinetic properties and reproducibl...
  10. Molecular imaging using nanoparticle quenchers of Cerenkov luminescence.

    Small 10(18):3729 (2014) PMID 24861843 PMCID PMC4167912

    Cerenkov luminescence (CL) imaging is an emerging technique that collects the visible photons produced by radioisotopes. Here, molecular imaging strategies are investigated that switch the CL signal off. The noninvasive molecularly specific detection of cancer is demonstrated utilizing a combina...
  11. Molecular imaging using nanoparticle quenchers of Cerenkov luminescence.

    Small 10(18):3729 (2014) PMID 24861843 PMCID PMC4167912

    Cerenkov luminescence (CL) imaging is an emerging technique that collects the visible photons produced by radioisotopes. Here, molecular imaging strategies are investigated that switch the CL signal off. The noninvasive molecularly specific detection of cancer is demonstrated utilizing a combina...
  12. Advances in active and passive immunotherapy for Alzheimer's disease

    Neurobiology of Aging 35:S10 (2014)

  13. Reply: Human Cerenkov imaging using 18F-FDG.

    Journal of nuclear medicine : official publicat... 55(3):523 (2014) PMID 24449595

  14. Advances in active and passive immunotherapy for Alzheimer's disease

    Neurobiology of Aging 35:S10 (2014)

  15. Reply: Human Cerenkov imaging using 18F-FDG.

    Journal of nuclear medicine : official publicat... 55(3):523 (2014) PMID 24449595

  16. Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle.

    Nature Communications 5:3097 (2014) PMID 24445347 PMCID PMC4080716

    The invasion status of tumour-draining lymph nodes (LNs) is a critical indicator of cancer stage and is important for treatment planning. Clinicians currently use planar scintigraphy and single-photon emission computed tomography (SPECT) with (99m)Tc-radiocolloid to guide biopsy and resection of...
  17. Dawn of advanced molecular medicine: nanotechnological advancements in cancer imaging and therapy.

    Critical Reviews in Oncogenesis 19(3-4):143 (2014) PMID 25271430 PMCID PMC4183929

    Nanotechnology plays an increasingly important role not only in our everyday life (with all its benefits and dangers) but also in medicine. Nanoparticles are to date the most intriguing option to deliver high concentrations of agents specifically and directly to cancer cells; therefore, a wide v...
  18. Cerenkov imaging.

    Advances in Cancer Research 124:213 (2014) PMID 25287690

    Cerenkov luminescence (CL) has been used recently in a plethora of medical applications like imaging and therapy with clinically relevant medical isotopes. The range of medical isotopes used is fairly large and expanding. The generation of in vivo light is useful since it circumvents depth limit...
  19. Cerenkov imaging.

    Advances in Cancer Research 124:213 (2014) PMID 25287690 PMCID PMC4329979

    Cerenkov luminescence (CL) has been used recently in a plethora of medical applications like imaging and therapy with clinically relevant medical isotopes. The range of medical isotopes used is fairly large and expanding. The generation of in vivo light is useful since it circumvents depth limit...
  20. Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching.

    Nature Communications 5:3384 (2014) PMID 24594970 PMCID PMC4108301

    The effective delivery of therapeutics to disease sites significantly contributes to drug efficacy, toxicity and clearance. Here we demonstrate that clinically approved iron oxide nanoparticles (Ferumoxytol) can be utilized to carry one or multiple drugs. These so called 'nanophores' retain thei...