1. Lymph Node Micrometastases and In-Transit Metastases from Melanoma: In Vivo Detection with Multispectral Optoacoustic Imaging in a Mouse Model.

    Radiology 280(1):137 (2016) PMID 27144537 PMCID PMC4942996

    Purpose To study whether multispectral optoacoustic tomography (MSOT) can serve as a label-free imaging modality for the detection of lymph node micrometastases and in-transit metastases from melanoma on the basis of the intrinsic contrast of melanin in comparison to fluorine 18 fluorodeoxygluco...
  2. Multifunctional MRI/PET Nanobeacons Derived from the in Situ Self-Assembly of Translational Polymers and Clinical Cargo through Coalescent Intermolecular Forces.

    Nano Letters 15(12):8032 (2015) PMID 26540670 PMCID PMC4703344

    Novel multifunctional platforms are needed for oncology in order to assist physicians during surgery and chemotherapy. In the present study, we show that polymeric nanobeacons, consisting of the glucose-based polymer dextran, can be used to guide surgery and improve drug delivery. For imaging, t...
  3. Broadly neutralizing human monoclonal JC polyomavirus VP1-specific antibodies as candidate therapeutics for progressive multifocal leukoencephalopathy.

    Science Translational Medicine 7(306):306ra150 (2015) PMID 26400911 PMCID PMC4820754

    In immunocompromised individuals, JC polyomavirus (JCPyV) may mutate and gain access to the central nervous system resulting in progressive multifocal leukoencephalopathy (PML), an often fatal opportunistic infection for which no treatments are currently available. Despite recent progress, the c...
  4. Cerenkov Luminescence Imaging for Radiation Dose Calculation of a ⁹⁰Y-Labeled Gastrin-Releasing Peptide Receptor Antagonist.

    Journal of nuclear medicine : official publicat... 56(5):805 (2015) PMID 25840974 PMCID PMC4470706

    (90)Y has been used to label various new therapeutic radiopharmaceuticals. However, measuring the radiation dose delivered by (90)Y is challenging because of the absence of suitable γ emissions and its low abundance of positron emissions. For the treatment of prostate cancer, radiolabeled gastri...
  5. Molecular imaging of prostate cancer: translating molecular biology approaches into the clinical realm.

    European Radiology 25(5):1294 (2015) PMID 25693661

    The epidemiology of prostate cancer has dramatically changed since the introduction of prostate-specific antigen (PSA) screening in the 1980's. Most prostate cancers today are detected at early stages of the disease and are considered 'indolent'; however, some patients' prostate cancers demonstr...
  6. Cancer nanomedicine: Therapy from within.

    Nature Nanotechnology 10(4):299 (2015) PMID 25855256

  7. Silica nanoparticles as substrates for chelator-free labeling of oxophilic radioisotopes.

    Nano Letters 15(2):864 (2015) PMID 25559467 PMCID PMC4412311

    Chelator-free nanoparticles for intrinsic radiolabeling are highly desirable for whole-body imaging and therapeutic applications. Several reports have successfully demonstrated the principle of intrinsic radiolabeling. However, the work done to date has suffered from much of the same specificity...
  8. Nanoparticles for imaging: top or flop?

    Radiology 273(1):10 (2014) PMID 25247562 PMCID PMC4186876

    Nanoparticles are frequently suggested as diagnostic agents. However, except for iron oxide nanoparticles, diagnostic nanoparticles have been barely incorporated into clinical use so far. This is predominantly due to difficulties in achieving acceptable pharmacokinetic properties and reproducibl...
  9. Molecular imaging using nanoparticle quenchers of Cerenkov luminescence.

    Small 10(18):3729 (2014) PMID 24861843 PMCID PMC4167912

    Cerenkov luminescence (CL) imaging is an emerging technique that collects the visible photons produced by radioisotopes. Here, molecular imaging strategies are investigated that switch the CL signal off. The noninvasive molecularly specific detection of cancer is demonstrated utilizing a combina...
  10. Reply: Human Cerenkov imaging using 18F-FDG.

    Journal of nuclear medicine : official publicat... 55(3):523 (2014) PMID 24449595

  11. Advances in active and passive immunotherapy for Alzheimer's disease

    Neurobiology of Aging 35:S10 (2014)

  12. Chapter Six - Cerenkov Imaging

    Advances in Cancer Research 124:213 (2014) PMID 25287690 PMCID PMC4329979

    Cerenkov luminescence (CL) has been used recently in a plethora of medical applications like imaging and therapy with clinically relevant medical isotopes. The range of medical isotopes used is fairly large and expanding. The generation of in vivo light is useful since it circumvents d...
  13. Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle.

    Nature Communications 5:3097 (2014) PMID 24445347 PMCID PMC4080716

    The invasion status of tumour-draining lymph nodes (LNs) is a critical indicator of cancer stage and is important for treatment planning. Clinicians currently use planar scintigraphy and single-photon emission computed tomography (SPECT) with (99m)Tc-radiocolloid to guide biopsy and resection of...
  14. Clinical Cerenkov luminescence imaging of (18)F-FDG.

    Journal of nuclear medicine : official publicat... 55(1):95 (2014) PMID 24078721 PMCID PMC3903390

    The aim of this study was to determine the feasibility of Cerenkov luminescence (CL) imaging of patients undergoing diagnostic (18)F-FDG scans to detect nodal disease. Patients undergoing routine (18)F-FDG PET/CT for various malignancies consented to being scanned for CL. White-light and Cerenko...
  15. Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching.

    Nature Communications 5:3384 (2014) PMID 24594970 PMCID PMC4108301

    The effective delivery of therapeutics to disease sites significantly contributes to drug efficacy, toxicity and clearance. Here we demonstrate that clinically approved iron oxide nanoparticles (Ferumoxytol) can be utilized to carry one or multiple drugs. These so called 'nanophores' retain thei...
  16. Dawn of advanced molecular medicine: nanotechnological advancements in cancer imaging and therapy.

    Critical Reviews in Oncogenesis 19(3-4):143 (2014) PMID 25271430 PMCID PMC4183929

    Nanotechnology plays an increasingly important role not only in our everyday life (with all its benefits and dangers) but also in medicine. Nanoparticles are to date the most intriguing option to deliver high concentrations of agents specifically and directly to cancer cells; therefore, a wide v...
  17. Quantitative imaging of disease signatures through radioactive decay signal conversion.

    Nature Medicine 19(10):1345 (2013) PMID 24013701 PMCID PMC3795968

    In the era of personalized medicine, there is an urgent need for in vivo techniques able to sensitively detect and quantify molecular activities. Sensitive imaging of gamma rays is widely used; however, radioactive decay is a physical constant, and its signal is independent of biological interac...
  18. Positron lymphography: multimodal, high-resolution, dynamic mapping and resection of lymph nodes after intradermal injection of 18F-FDG.

    Journal of nuclear medicine : official publicat... 53(9):1438 (2012) PMID 22872741 PMCID PMC3537831

    The lymphatic system plays a critical role in the maintenance of healthy tissues. Its function is an important indicator of the presence and extent of disease. In oncology, metastatic spread to local lymph nodes (LNs) is a strong predictor of poor outcome. Clinical methods for the visualization ...
  19. Gadolinium-encapsulating iron oxide nanoprobe as activatable NMR/MRI contrast agent.

    ACS Nano 6(8):7281 (2012) PMID 22809405 PMCID PMC3429787

    Herein we report a novel gadolinium-encapsulating iron oxide nanoparticle-based activatable NMR/MRI nanoprobe. In our design, Gd-DTPA is encapsulated within the poly(acrylic acid) (PAA) polymer coating of a superparamagnetic iron oxide nanoparticle (IO-PAA), yielding a composite magnetic nanopro...
  20. 35 Antibody therapy of Alzheimer's disease

    Neurobiology of Aging 33:S16 (2012)