1. Permselective 2D-polymer-based membrane tuneable by host-guest chemistry.

    Chemical Communications 52(62):9676 (2016) PMID 27400648

    A permselective membrane with a non-covalently tailorable surface has been fabricated by deposition of a cucurbit[6]uril-based 2D polymer film onto a simple support membrane. Tuneable permselectivity of this membrane has been achieved through non-covalent surface modification using the remarkabl...
  2. Phase 2 multicentre trial investigating intermittent and continuous dosing schedules of the poly(ADP-ribose) polymerase inhibitor rucaparib in germline BRCA mutation carriers with advanced ovarian and breast cancer.

    British Journal of Cancer 114(12):e21 (2016) PMID 27228289

  3. Evaluation of a patient self-directed mealtime insulin titration algorithm: a US payer perspective.

    Journal of Medical Economics 19(6):549 (2016) PMID 26756804

    Objective To model the potential economic impact of implementing the AUTONOMY once daily (Q1D) patient self-titration mealtime insulin dosing algorithm vs standard of care (SOC) among a population of patients with Type 2 diabetes living in the US. Methods Three validated models were used in this...
  4. EBF1-PDGFRB fusion in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL): genetic profile and clinical implications.

    Blood 127(18):2214 (2016) PMID 26872634

    The EBF1-PDGFRB gene fusion accounts for <1% of B-cell precursor acute lymphoblastic leukemia (ALL) cases and occurs within the Philadelphia-like ALL subtype. We report 15 EBF1-PDGFRB-positive patients from childhood ALL treatment trials (ALL 97/99, UKALL 2003, UKALL 2011) in the United Kingdom....
  5. Phase 2 multicentre trial investigating intermittent and continuous dosing schedules of the poly(ADP-ribose) polymerase inhibitor rucaparib in germline BRCA mutation carriers with advanced ovarian and breast cancer.

    British Journal of Cancer 114(7):723 (2016) PMID 27002934 PMCID PMC4882768

    Rucaparib is an orally available potent selective small-molecule inhibitor of poly(ADP-ribose) polymerase (PARP) 1 and 2. Rucaparib induces synthetic lethality in cancer cells defective in the homologous recombination repair pathway including BRCA-1/2. We investigated the efficacy and safety of ...
  6. Effectiveness and cost-effectiveness of outpatient physiotherapy after knee replacement for osteoarthritis: study protocol for a randomised controlled trial.

    Trials 17(1):289 (2016) PMID 27296366 PMCID PMC4906683

    Primary total knee replacement is a common operation that is performed to provide pain relief and restore functional ability. Inpatient physiotherapy is routinely provided after surgery to enhance recovery prior to hospital discharge. However, international variation exists in the provision of o...
  7. Efficacy of PARP Inhibitor Rucaparib in Orthotopic Glioblastoma Xenografts Is Limited by Ineffective Drug Penetration into the Central Nervous System.

    Molecular Cancer Therapeutics 14(12):2735 (2015) PMID 26438157 PMCID PMC4674360

    PARP inhibition can enhance the efficacy of temozolomide and prolong survival in orthotopic glioblastoma (GBM) xenografts. The aim of this study was to evaluate the combination of the PARP inhibitor rucaparib with temozolomide and to correlate pharmacokinetic and pharmacodynamic studies with eff...
  8. Probing molecular interactions with methylene blue derivatized self-assembled monolayers

    Sensing and Bio-Sensing Research 6:1 (2015)

    The emergence of stratified and personalised medicine and the associated need for highly multiplexed detection strategies are driving the development of innovative sensor technology. Electronic immunosensor arrays capable of label-free and highly parallel monitoring of ligand binding h...
  9. Online Outreach Services Among Men Who Use the Internet to Seek Sex With Other Men (MISM) in Ontario, Canada: An Online Survey.

    Journal of medical Internet research 17(12):e277 (2015) PMID 26681440 PMCID PMC4704956

    Men who use the Internet to seek sex with other men (MISM) are increasingly using the Internet to find sexual health information and to seek sexual partners, with some research suggesting HIV transmission is associated with sexual partnering online. Aiming to "meet men where they are at," some A...
  10. VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells.

    Oncotarget 5(24):12862 (2014) PMID 25404640 PMCID PMC4350332

    Pyruvate dehydrogenase kinase (PDK) is a pivotal enzyme in cellular energy metabolism that has previously been implicated in cancer through both RNAi based studies and clinical correlations with poor prognosis in several cancer types. Here, we report the discovery of a novel and selective ATP co...
  11. In vitro oxygen availability modulates the effect of artesunate on HeLa cells.

    Anticancer Research 34(12):7055 (2014) PMID 25503132

    Hypoxia can affect chemotherapeutic drug efficacy in cancer patients, yet related in vitro assays in oxygen-rich environment remain the norm. Such levels are well beyond normoxic/hypoxic levels typically experienced by normal tissues/tumor masses. The present study evaluated how artesunate anti-...
  12. A response to the LENT score.

    Thorax 69(12):1144 (2014) PMID 25246667

  13. Video feedback in undergraduate practical skills learning – A surrogate for the trainee surgeon?

    International Journal of Surgery 12:S77 (2014)

  14. The lactoferrin receptor may mediate the reduction of eosinophils in the duodenum of pigs consuming milk containing recombinant human lactoferrin.

    BioMetals 27(5):1031 (2014) PMID 25085595

    Lactoferrin is part of the immune system and multiple tissues including the gastrointestinal (GI) tract, liver, and lung contain receptors for lactoferrin. Lactoferrin has many functions, including antimicrobial, immunomodulatory, and iron binding. Additionally, lactoferrin inhibits the migratio...
  15. Primary tuberculosis of the thyroid gland: an unexpected cause of thyrotoxicosis.

    BMJ Case Reports 2014 (2014) PMID 24577178 PMCID PMC3939388

    We describe a 38-year-old Indian man who presented with a 2-week history of fever, night sweats and neck swelling who was found to be clinically thyrotoxic with a nodular goitre, tachycardia and high fever. Biochemical investigation revealed hyperthyroidism in association with deranged liver fun...
  16. Minimally invasive total knee arthroplasty; a pragmatic randomised controlled trial reporting outcomes up to 2 year follow up.

    The Knee 21(1):189 (2014) PMID 23972565

    We present a prospective, randomised, multi-surgeon, controlled trial comparing minimally invasive (MIS) and standard approach total knee arthroplasty (TKA). Participants underwent unilateral TKA. Patients were randomised to Bristol, quadriceps sparing MIS or standard medial parapatellar approac...
  17. BASK presentations: progress to journal publication.

    Orthopedics 36(10):e1269 (2013) PMID 24093702

    Scientific conferences, such as the British Association for Surgery of the Knee (BASK) annual meeting, provide an important channel for the exchange of information between researchers. However, the ultimate means of disseminating research information is publication in a relevant peer-reviewed jo...
  18. Fragment screening by weak affinity chromatography: comparison with established techniques for screening against HSP90.

    Analytical chemistry 85(14):6756 (2013) PMID 23806099

    The increasing use of fragment-based lead discovery (FBLD) in industry as well as in academia creates a high demand for sensitive and reliable methods to detect the binding of fragments to act as starting points in drug discovery programs. Nuclear magnetic resonance (NMR), surface plasmon resona...
  19. Mature teratoma of the thymus.

    BMJ Case Reports 2013 (2013) PMID 24038290 PMCID PMC3794101

    A 55-year-old man presented with a 7-month history of an intermittent dry cough after returning from Turkey. A chest radiograph revealed a large mass-like opacity in the right lung field and CT demonstrated a 13 cm round, cystic lesion in the anterior mediastinum. The patient was referred to the...
  20. Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.

    Bioorganic & Medicinal Chemistry 20(22):6770 (2012) PMID 23018093

    Inhibitors of the Hsp90 molecular chaperone are showing promise as anti-cancer agents. Here we describe a series of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine ATP competitive Hsp90 inhibitors that were identified following structure-driven optimization of purine hits revealed by NMR based screening ...