1. Hypothalamic miR-103 protects from hyperphagic obesity in mice.

    Journal of Neuroscience 34(32):10659 (2014) PMID 25100599

    The role of neuronal noncoding RNAs in energy control of the body is not fully understood. The arcuate nucleus (ARC) of the hypothalamus comprises neurons regulating food intake and body weight. Here we show that Dicer-dependent loss of microRNAs in these neurons of adult (DicerCKO) mice causes ...
  2. Transcription factors Foxa1 and Foxa2 are required for adult dopamine neurons maintenance.

    Frontiers in Cellular Neuroscience 8:275 (2014) PMID 25249938 PMCID PMC4158790

    The proteins Foxa1 and Foxa2 belong to the forkhead family of transcription factors and are involved in the development of several tissues, including liver, pancreas, lung, prostate, and the neural system. Both Foxa1 and Foxa2 are also crucial for the specification and differentiation of dopamin...
  3. Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models.

    FASEB Journal 25(9):2898 (2011) PMID 21593433

    Parkinson's disease (PD) is a progressive age-related movement disorder that results primarily from the selective loss of midbrain dopaminergic (DA) neurons. Symptoms of PD can be induced by genetic mutations or by DA neuron-specific toxins. A specific ablation of an essential factor controlling...
  4. Low but sustained coagulation activation ameliorates glucose-induced podocyte apoptosis: protective effect of factor V Leiden in diabetic nephropathy.

    Blood 117(19):5231 (2011) PMID 21389321

    Whereas it is generally perceived to be harmful, enhanced coagulation activation can also convey salutary effects. The high prevalence of the prothrombotic factor V Leiden (FVL) mutation in whites has been attributed to a positive selection pressure (eg, resulting from reduced blood loss or impr...
  5. Hypercoagulability inhibits monocyte transendothelial migration through protease-activated receptor-1-, phospholipase-Cbeta-, phosphoinositide 3-kinase-, and nitric oxide-dependent signaling in monocytes and promotes plaque stability.

    Circulation 120(9):774 (2009) PMID 19687358

    Clinical studies failed to provide clear evidence for a proatherogenic role of hypercoagulability. This is in contrast to the well-established detrimental role of hypercoagulability and thrombin during acute atherosclerotic complications. These seemingly opposing data suggest that hypercoagulabi...
  6. Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis.

    Nature Medicine 13(11):1349 (2007) PMID 17982464

    Data providing direct evidence for a causative link between endothelial dysfunction, microvascular disease and diabetic end-organ damage are scarce. Here we show that activated protein C (APC) formation, which is regulated by endothelial thrombomodulin, is reduced in diabetic mice and causally l...
  7. Purification of filamentous bacteriophage for phage display using size-exclusion chromatography.

    BioTechniques 38(2):194, 196, 198 (2005) PMID 15727124