1. Mechanisms of disease: The human N-glycome.

    Biochimica et Biophysica Acta 1860(8):1574 (2016) PMID 26500099

    The majority of human proteins are being modified by covalent attachment of complex oligosaccharides--glycans. Both glycans and polypeptide parts of a protein contribute to its structure and function, but contrary to polypeptide that is defined by the sequence of nucleotides in the corresponding...
  2. Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.
    Aysu Okbay, Bart M L Baselmans, Jan-Emmanuel De Neve, Patrick Turley, Michel G Nivard, Mark Alan Fontana, S Fleur W Meddens, Richard Karlsson Linnér, Cornelius A Rietveld, Jaime Derringer, Jacob Gratten, James Lee, Jimmy Z Liu, Ronald de Vlaming, Tarunveer S Ahluwalia, Jadwiga Buchwald, Alana Cavadino, Alexis C Frazier-Wood, Nicholas A Furlotte, Victoria Garfield, Marie Henrike Geisel, Juan R Gonzalez, Saskia Haitjema, Robert Karlsson, Sander W van der Laan, Karl-Heinz Ladwig, Jari Lahti, Sven J van der Lee, Penelope A Lind, Tian Liu, Lindsay Matteson, Evelin Mihailov, Michael B Miller, Camelia Minica, Ilja M Nolte, Dennis Mook-Kanamori, Peter J van der Most, Christopher Oldmeadow, Yong Qian, Olli Raitakari, Rajesh Rawal, Anu Realo, Rico Rueedi, Börge Schmidt, Albert V Smith, Evie Stergiakouli, Toshiko Tanaka, Kent Taylor, Gudmar Thorleifsson, Juho Wedenoja, Juergen Wellmann, Harm-Jan Westra, Sara M Willems, Wei Zhao, Najaf Amin, Andrew Bakshi, Sven Bergmann, Gyda Bjornsdottir, Patricia A Boyle, Samantha Cherney, Simon R Cox, Gail Davies, Oliver S P Davis, Jun Ding, Nese Direk, Peter Eibich, Rebecca T Emeny, Ghazaleh Fatemifar, Jessica D Faul, Luigi Ferrucci, Andreas J Forstner, Christian Gieger, Richa Gupta, Tamara B Harris, Juliette M Harris, Elizabeth G Holliday, Hottenga, Philip L De Jager, Marika A Kaakinen, Eero Kajantie, Ville Karhunen, Ivana Kolcic, Meena Kumari, Lenore J Launer, Lude Franke, Ruifang Li-Gao, David C Liewald, Marisa Koini, Anu Loukola, Pedro Marques-Vidal, Grant W Montgomery, Miriam A Mosing, Lavinia Paternoster, Alison Pattie, Katja E Petrovic, Laura Pulkki-Råback, Lydia Quaye, Katri Räikkönen, Igor Rudan, Rodney J Scott, Jennifer A Smith, Angelina R Sutin, Maciej Trzaskowski, Anna E Vinkhuyzen, Lei Yu, Delilah Zabaneh, John R Attia, David A Bennett, Klaus Berger, Lars Bertram, Dorret I Boomsma, Harold Snieder, Shun-Chiao Chang, Francesco Cucca, Ian J Deary, Cornelia M van Duijn, Johan G Eriksson, Ute Bültmann, Eco J C de Geus, Patrick J F Groenen, Vilmundur Gudnason, Torben Hansen, Catharine A Hartman, Claire M A Haworth, Caroline Hayward, Andrew C Heath, David A Hinds, Elina Hyppönen, William G Iacono, Marjo-Riitta Järvelin, Karl-Heinz Jöckel, Jaakko Kaprio, Sharon L R Kardia, Liisa Keltikangas-Järvinen, Peter Kraft, Laura D Kubzansky, Terho Lehtimäki, Patrik K E Magnusson, Nicholas G Martin, Matt McGue, Andres Metspalu, Melinda Mills, Renée de Mutsert, Albertine J Oldehinkel, Gerard Pasterkamp, Nancy L Pedersen, Robert Plomin, Ozren Polasek, Christine Power, Stephen Rich, Frits Rosendaal, Hester M den Ruijter, David Schlessinger, Helena Schmidt, Rauli Svento, Reinhold Schmidt, Behrooz Z Alizadeh, Thorkild I A Sørensen, Tim D Spector, John M Starr, Kari Stefansson, Andrew Steptoe, Antonio Terracciano, Unnur Thorsteinsdottir, A Roy Thurik, Nicholas J Timpson, Henning Tiemeier, André G Uitterlinden, Peter Vollenweider, Gert Wagner, David R Weir, Jian Yang, Dalton Conley, George Davey Smith, Albert Hofman, Magnus Johannesson, David I Laibson, Sarah E Medland, Michelle N Meyer, Joseph K Pickrell, Tõnu Esko, Robert F Krueger, Jonathan P Beauchamp, Philipp D Koellinger, Daniel J Benjamin, Meike Bartels, and David Cesarini

    Nature Genetics 48(8):970 (2016) PMID 27463399

  3. Profiling IgG N-glycans as potential biomarker of chronological and biological ages: A community-based study in a Han Chinese population.

    Medicine (Baltimore) 95(28):e4112 (2016) PMID 27428197 PMCID PMC4956791

    As an important post-translation modifying process, glycosylation significantly affects the structure and function of immunoglobulin G (IgG) molecules and is essential in many steps of the inflammatory cascade. Studies have demonstrated the potential of using glycosylation features of IgG as a c...
  4. Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels.
    Elisabeth M van Leeuwen, Aniko Sabo, Joshua C Bis, Jennifer E Huffman, Ani Manichaikul, Albert V Smith, Mary Feitosa, Serkalem Demissie, Peter K Joshi, Qing Duan, Jonathan Marten, Jan B van Klinken, Ida Surakka, Ilja M Nolte, Weihua Zhang, Hamdi Mbarek, Ruifang Li-Gao, Stella Trompet, Niek Verweij, Evangelos Evangelou, Leo-Pekka Lyytikäinen, Bamidele O Tayo, Joris Deelen, Peter J van der Most, Sander W van der Laan, Dan E Arking, Alanna Morrison, Abbas Dehghan, Oscar H Franco, Albert Hofman, Fernando Rivadeneira, Eric J Sijbrands, Andre G Uitterlinden, Josyf C Mychaleckyj, Archie Campbell, Lynne J Hocking, Sandosh Padmanabhan, Jennifer A Brody, Kenneth M Rice, Charles White, Tamara Harris, Aaron Isaacs, Harry Campbell, Leslie A Lange, Igor Rudan, Ivana Kolcic, Pau Navarro, Tatijana Zemunik, Veikko Salomaa, Angad S Kooner, Jaspal S Kooner, Benjamin Lehne, William R Scott, Sian-Tsung Tan, Eco J de Geus, Yuri Milaneschi, Brenda W J H Penninx, Gonneke Willemsen, Renée de Mutsert, Ian Ford, Ron T Gansevoort, Marcelo P Segura-Lepe, Olli T Raitakari, Jorma S Viikari, Kjell Nikus, Terrence Forrester, Colin A McKenzie, Anton J M de Craen, Hester M de Ruijter, Gerard Pasterkamp, Harold Snieder, Albertine J Oldehinkel, P Eline Slagboom, Richard S Cooper, Mika Kähönen, Terho Lehtimäki, Paul Elliott, Pim van der Harst, Wouter Jukema, Dennis O Mook-Kanamori, Dorret I Boomsma, John Chambers, Morris Swertz, Samuli Ripatti, Ko Willems van Dijk, Veronique Vitart, Ozren Polasek, Caroline Hayward, James G Wilson, James F Wilson, Vilmundur Gudnason, Stephen Rich, Bruce M Psaty, Ingrid Borecki, Eric Boerwinkle, Jerome I Rotter, L Adrienne Cupples, and Cornelia M van Duijn

    Journal of Medical Genetics 53(7):441 (2016) PMID 27036123 PMCID PMC4941146

    So far, more than 170 loci have been associated with circulating lipid levels through genome-wide association studies (GWAS). These associations are largely driven by common variants, their function is often not known, and many are likely to be markers for the causal variants. In this study we a...
  5. An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group.

    Genetic Epidemiology 40(5):404 (2016) PMID 27230302 PMCID PMC4911246

    Studying gene-environment (G × E) interactions is important, as they extend our knowledge of the genetic architecture of complex traits and may help to identify novel variants not detected via analysis of main effects alone. The main statistical framework for studying G × E interactions uses a s...
  6. Structure, function and five basic needs of the global health research system.

    Journal of global health 6(1):010505 (2016) PMID 26401270 PMCID PMC4576460

    Two major initiatives that were set up to support and co-ordinate global health research efforts have been largely discontinued in recent years: the Global Forum for Health Research and World Health Organization's Department for Research Policy and Cooperation. These developments provide an inte...
  7. Setting health research priorities using the CHNRI method: VI. Quantitative properties of human collective opinion.

    Journal of Global Health 6(1):010503 (2016) PMID 27350874 PMCID PMC4920008

    Crowdsourcing has become an increasingly important tool to address many problems - from government elections in democracies, stock market prices, to modern online tools such as TripAdvisor or Internet Movie Database (IMDB). The CHNRI method (the acronym for the Child Health and Nutrition Researc...
  8. Guidelines for Accurate and Transparent Health Estimates Reporting: the GATHER statement.

    PLOS Medicine 13(6):e1002056 (2016) PMID 27351744 PMCID PMC4924581

    Gretchen Stevens and colleagues present the GATHER statement, which seeks to promote good practice in the reporting of global health estimates.
  9. Setting health research priorities using the CHNRI method: I. Involving funders.

    Journal of global health 6(1):010301 (2016) PMID 26401269 PMCID PMC4576461

  10. Setting research priorities to improve global newborn health and prevent stillbirths by 2025.
    Sachiyo Yoshida, José Martines, Joy E Lawn, Stephen Wall, Joăo Paulo Souza, Igor Rudan, Simon Cousens, Peter Aaby, Ishag Adam, Ramesh Kant Adhikari, Namasivayam Ambalavanan, Shams Ei Arifeen, Dhana Raj Aryal, Sk Asiruddin, Abdullah Baqui, Aluisio Jd Barros, Christine S Benn, Vineet Bhandari, Shinjini Bhatnagar, Sohinee Bhattacharya, Zulfiqar A Bhutta, Robert E Black, Hannah Blencowe, Carl Bose, Justin Brown, Christoph Bührer, Wally Carlo, Jose Guilherme Cecatti, Po-Yin Cheung, Robert Clark, Tim Colbourn, Agustin Conde-Agudelo, Erica Corbett, Andrew E Czeizel, Abhik Das, Louise Tina Day, Carolyn Deal, Ashok Deorari, Uğur Dilmen, Mike English, Cyril Engmann, Fabian Esamai, Caroline Fall, Donna M Ferriero, Peter Gisore, Tabish Hazir, Rosemary D Higgins, Caroline Se Homer, D E Hoque, Lorentz Irgens, M T Islam, Joseph de Graft-Johnson, Martias Alice Joshua, William Keenan, Soofia Khatoon, Helle Kieler, Michael S Kramer, Eve M Lackritz, Tina Lavender, Laurensia Lawintono, Richard Luhanga, David Marsh, Douglas, Patrick J McNamara, Ben Willem J Mol, Elizabeth Molyneux, G K Mukasa, Miriam Mutabazi, Luis Carlos Nacul, Margaret Nakakeeto, Indira Narayanan, Bolajoko Olusanya, David Osrin, Vinod Paul, Christian Poets, Uma M Reddy, Mathuram Santosham, Rubayet Sayed, Natalia E Schlabritz-Loutsevitch, Nalini Singhal, Mary Alice Smith, Peter G Smith, Sajid Soofi, Catherine Y Spong, Shahin Sultana, Antoinette Tshefu, Frank van Bel, Lauren Vestewig Gray, Peter Waiswa, Wei Wang, Sarah LA Williams, Linda Wright, Anita Zaidi, Yanfeng Zhang, Nanbert Zhong, Isabel Zuniga, and Rajiv Bahl

    Journal of global health 6(1):010508 (2016) PMID 26401272 PMCID PMC4576458

    In 2013, an estimated 2.8 million newborns died and 2.7 million were stillborn. A much greater number suffer from long term impairment associated with preterm birth, intrauterine growth restriction, congenital anomalies, and perinatal or infectious causes. With the approaching deadline for the a...
  11. Setting health research priorities using the CHNRI method: IV. Key conceptual advances.

    Journal of Global Health 6(1):010501 (2016) PMID 27418959 PMCID PMC4938380

    Child Health and Nutrition Research Initiative (CHNRI) started as an initiative of the Global Forum for Health Research in Geneva, Switzerland. Its aim was to develop a method that could assist priority setting in health research investments. The first version of the CHNRI method was published i...
  12. Setting health research priorities using the CHNRI method: V. Quantitative properties of human collective knowledge.

    Journal of Global Health 6(1):010502 (2016) PMID 27350873 PMCID PMC4920010

    The CHNRI method for setting health research priorities has crowdsourcing as the major component. It uses the collective opinion of a group of experts to generate, assess and prioritize between many competing health research ideas. It is difficult to compare the accuracy of human individual and ...
  13. Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.
    Aysu Okbay, Bart M L Baselmans, Jan-Emmanuel De Neve, Patrick Turley, Michel G Nivard, Mark Alan Fontana, S Fleur W Meddens, Richard Karlsson Linnér, Cornelius A Rietveld, Jaime Derringer, Jacob Gratten, James Lee, Jimmy Z Liu, Ronald de Vlaming, Tarunveer S Ahluwalia, Jadwiga Buchwald, Alana Cavadino, Alexis C Frazier-Wood, Nicholas A Furlotte, Victoria Garfield, Marie Henrike Geisel, Juan R Gonzalez, Saskia Haitjema, Robert Karlsson, Sander W van der Laan, Karl-Heinz Ladwig, Jari Lahti, Sven J van der Lee, Penelope A Lind, Tian Liu, Lindsay Matteson, Evelin Mihailov, Michael B Miller, Camelia Minica, Ilja M Nolte, Dennis Mook-Kanamori, Peter J van der Most, Christopher Oldmeadow, Yong Qian, Olli Raitakari, Rajesh Rawal, Anu Realo, Rico Rueedi, Börge Schmidt, Albert V Smith, Evie Stergiakouli, Toshiko Tanaka, Kent Taylor, Juho Wedenoja, Juergen Wellmann, Harm-Jan Westra, Sara M Willems, Wei Zhao, Najaf Amin, Andrew Bakshi, Patricia A Boyle, Samantha Cherney, Simon R Cox, Gail Davies, Oliver S P Davis, Jun Ding, Nese Direk, Peter Eibich, Rebecca T Emeny, Ghazaleh Fatemifar, Jessica D Faul, Luigi Ferrucci, Andreas Forstner, Christian Gieger, Richa Gupta, Tamara B Harris, Juliette M Harris, Elizabeth G Holliday, Hottenga, Philip L De Jager, Marika A Kaakinen, Eero Kajantie, Ville Karhunen, Ivana Kolcic, Meena Kumari, Lenore J Launer, Lude Franke, Ruifang Li-Gao, Marisa Koini, Anu Loukola, Pedro Marques-Vidal, Grant W Montgomery, Miriam A Mosing, Lavinia Paternoster, Alison Pattie, Katja E Petrovic, Laura Pulkki-Råback, Lydia Quaye, Katri Räikkönen, Igor Rudan, Rodney J Scott, Jennifer A Smith, Angelina R Sutin, Maciej Trzaskowski, Anna E Vinkhuyzen, Lei Yu, Delilah Zabaneh, John R Attia, David A Bennett, Klaus Berger, Lars Bertram, Dorret I Boomsma, Harold Snieder, Shun-Chiao Chang, Francesco Cucca, Ian J Deary, Cornelia M van Duijn, Johan G Eriksson, Ute Bültmann, Eco J C de Geus, Patrick J F Groenen, Vilmundur Gudnason, Torben Hansen, Catharine A Hartman, Claire M A Haworth, Caroline Hayward, Andrew C Heath, David A Hinds, Elina Hyppönen, William G Iacono, Marjo-Riitta Järvelin, Karl-Heinz Jöckel, Jaakko Kaprio, Sharon L R Kardia, Liisa Keltikangas-Järvinen, Peter Kraft, Laura D Kubzansky, Terho Lehtimäki, Patrik K E Magnusson, Nicholas G Martin, Matt McGue, Andres Metspalu, Melinda Mills, Renée de Mutsert, Albertine J Oldehinkel, Gerard Pasterkamp, Nancy L Pedersen, Robert Plomin, Ozren Polasek, Christine Power, Stephen Rich, Frits Rosendaal, Hester M den Ruijter, David Schlessinger, Helena Schmidt, Rauli Svento, Reinhold Schmidt, Behrooz Z Alizadeh, Thorkild I A Sørensen, Tim D Spector, Andrew Steptoe, Antonio Terracciano, A Roy Thurik, Nicholas J Timpson, Henning Tiemeier, André G Uitterlinden, Peter Vollenweider, Gert Wagner, David R Weir, Jian Yang, Dalton Conley, George Davey Smith, Albert Hofman, Magnus Johannesson, David I Laibson, Sarah E Medland, Michelle N Meyer, Joseph K Pickrell, Tõnu Esko, Robert F Krueger, Jonathan P Beauchamp, Philipp D Koellinger, Daniel J Benjamin, Meike Bartels, and David Cesarini

    Nature Genetics 48(6):624 (2016) PMID 27089181 PMCID PMC4884152

    Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conduc...
  14. Genome-wide association study identifies 74 loci associated with educational attainment.
    Aysu Okbay, Jonathan P Beauchamp, Mark Alan Fontana, James Lee, Tune H Pers, Cornelius A Rietveld, Patrick Turley, Guo-Bo Chen, Valur Emilsson, S Fleur W Meddens, Sven Oskarsson, Joseph K Pickrell, Kevin Thom, Pascal Timshel, Ronald de Vlaming, Abdel Abdellaoui, Tarunveer S Ahluwalia, Jonas Bacelis, Clemens Baumbach, Gyda Bjornsdottir, Johannes H Brandsma, Maria Pina Concas, Jaime Derringer, Nicholas A Furlotte, Tessel E Galesloot, Giorgia Girotto, Richa Gupta, Leanne M Hall, Sarah E Harris, Edith Hofer, Momoko Horikoshi, Jennifer E Huffman, Kadri Kaasik, Ioanna P Kalafati, Robert Karlsson, Augustine Kong, Jari Lahti, Sven J van der Lee, Christiaan deLeeuw, Penelope A Lind, Karl-Oskar Lindgren, Tian Liu, Massimo Mangino, Jonathan Marten, Evelin Mihailov, Michael B Miller, Peter J van der Most, Christopher Oldmeadow, Antony Payton, Natalia Pervjakova, Wouter J Peyrot, Yong Qian, Olli Raitakari, Rico Rueedi, Erika Salvi, Börge Schmidt, Katharina E Schraut, Jianxin Shi, Albert V Smith, Raymond A Poot, Beate St Pourcain, Alexander Teumer, Gudmar Thorleifsson, Niek Verweij, Dragana Vuckovic, Juergen Wellmann, Harm-Jan Westra, Jingyun Yang, Wei Zhao, Zhihong Zhu, Behrooz Z Alizadeh, Najaf Amin, Andrew Bakshi, Sebastian E Baumeister, Ginevra Biino, Klaus Bønnelykke, Patricia A Boyle, Harry Campbell, Francesco P Cappuccio, Gail Davies, Jan-Emmanuel De Neve, Panos Deloukas, Ilja Demuth, Jun Ding, Peter Eibich, Lewin Eisele, Niina Eklund, David M Evans, Jessica D Faul, Mary Feitosa, Andreas J Forstner, Ilaria Gandin, Bjarni Gunnarsson, Bjarni V Halldórsson, Tamara B Harris, Andrew C Heath, Lynne J Hocking, Elizabeth G Holliday, Georg Homuth, Michael A Horan, Hottenga, Philip L de Jager, Peter K Joshi, Astanand Jugessur, Marika A Kaakinen, Mika Kähönen, Stavroula Kanoni, Liisa Keltigangas-Järvinen, Lambertus A M Kiemeney, Ivana Kolcic, Seppo Koskinen, Aldi T Kraja, Martin Kroh, Zoltan Kutalik, Antti Latvala, Lenore J Launer, Maël P Lebreton, Douglas F Levinson, Paul Lichtenstein, Peter Lichtner, David C M Liewald, Anu Loukola, Pamela A Madden, Reedik Mägi, Tomi Mäki-Opas, Riccardo E Marioni, Pedro Marques-Vidal, Gerardus A Meddens, George, Christa Meisinger, Thomas Meitinger, Yusplitri Milaneschi, Lili Milani, Grant W Montgomery, Ronny Myhre, Christopher P Nelson, Dale R Nyholt, William E R Ollier, Aarno Palotie, Lavinia Paternoster, Nancy L Pedersen, Katja E Petrovic, David J Porteous, Katri Räikkönen, Susan M Ring, Antonietta Robino, Olga Rostapshova, Igor Rudan, Aldo Rustichini, Veikko Salomaa, Alan R Sanders, Antti-Pekka Sarin, Helena Schmidt, Rodney J Scott, Blair H Smith, Jennifer A Smith, Jan A Staessen, Elisabeth Steinhagen-Thiessen, Konstantin Strauch, Antonio Terracciano, Martin D Tobin, Sheila Ulivi, Simona Vaccargiu, Lydia Quaye, Frank J A van Rooij, Cristina Venturini, Anna E Vinkhuyzen, Uwe Völker, Henry Völzke, Judith M Vonk, Diego Vozzi, Johannes Waage, Erin B Ware, Gonneke Willemsen, John R Attia, David A Bennett, Klaus Berger, Lars Bertram, Hans Bisgaard, Dorret I Boomsma, Ingrid Borecki, Ute Bültmann, Christopher F Chabris, Francesco Cucca, Daniele Cusi, Ian J Deary, George V Dedoussis, Cornelia M van Duijn, Johan G Eriksson, Barbara Franke, Lude Franke, Paolo Gasparini, Pablo V Gejman, Christian Gieger, Hans-Jörgen Grabe, Jacob Gratten, Patrick J F Groenen, Vilmundur Gudnason, Pim van der Harst, Caroline Hayward, David A Hinds, Wolfgang Hoffmann, Elina Hyppönen, William G Iacono, Bo Jacobsson, Marjo-Riitta Järvelin, Karl-Heinz Jöckel, Jaakko Kaprio, Sharon L R Kardia, Terho Lehtimäki, Steven F Lehrer, Patrik K E Magnusson, Nicholas G Martin, Matt McGue, Andres Metspalu, Neil Pendleton, Brenda W J H Penninx, Markus Perola, Nicola Pirastu, Mario Pirastu, Ozren Polasek, Danielle Posthuma, Christine Power, Michael A Province, Nilesh J Samani, David Schlessinger, Reinhold Schmidt, Thorkild I A Sørensen, Tim D Spector, Kari Stefansson, Unnur Thorsteinsdottir, A Roy Thurik, Nicholas J Timpson, Henning Tiemeier, Joyce Y Tung, André G Uitterlinden, Veronique Vitart, Peter Vollenweider, David R Weir, James F Wilson, Alan F Wright, Dalton Conley, Robert F Krueger, George Davey Smith, Albert Hofman, David I Laibson, Sarah E Medland, Michelle N Meyer, Jian Yang, Magnus Johannesson, Peter M Visscher, Tõnu Esko, Philipp D Koellinger, David Cesarini, and Daniel J Benjamin

    Nature 533(7604):539 (2016) PMID 27225129 PMCID PMC4883595

    Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals. Here we report the results of a genome-wide association study (GWAS) for educational attainment that extends...
  15. The Association Between Glycosylation of Immunoglobulin G and Hypertension: A Multiple Ethnic Cross-Sectional Study.

    Medicine (Baltimore) 95(17):e3379 (2016) PMID 27124023

    More than half of all known proteins, and almost all membrane and extra-cellular proteins have oligosaccharide structures or glycans attached to them. Defects in glycosylation pathways are directly involved in at least 30 severe human diseases.A multiple center cross-sectional study (China, Croa...
  16. Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.
    Alexander Teumer, Adrienne Tin, Rossella Sorice, Mathias Gorski, Nan Cher Yeo, Audrey Y Chu, Man Li, Yong Li, Vladan Mijatovic, Yi-An Ko, Daniel Taliun, Alessandro Luciani, Ming-Huei Chen, Qiong Yang, Meredith C Foster, Matthias Olden, Linda T Hiraki, Bamidele O Tayo, Christian Fuchsberger, Aida Karina Dieffenbach, Alan R Shuldiner, Albert V Smith, Allison M Zappa, Antonio Lupo, Barbara Kollerits, Belen Ponte, Bénédicte Stengel, Bernhard Krämer, Bernhard Paulweber, Braxton D Mitchell, Caroline Hayward, Catherine Helmer, Christa Meisinger, Christian Gieger, Christian M Shaffer, Christian Müller, Claudia Langenberg, Daniel Ackermann, David Siscovick, Eric Boerwinkle, Florian Kronenberg, Georg B Ehret, Georg Homuth, Gerard Waeber, Gerjan Navis, Giovanni Gambaro, Giovanni Malerba, Gudny Eiriksdottir, Guo Li, H Erich Wichmann, Harald Grallert, Henri Wallaschofski, Henry Völzke, Herrmann Brenner, Holly Kramer, I Mateo Leach, Igor Rudan, Hans L Hillege, Jacques S Beckmann, Jean Charles Lambert, Jian'an Luan, Jing Hua Zhao, John Chalmers, Josef Coresh, Joshua C Denny, Katja Butterbach, Lenore J Launer, Luigi Ferrucci, Lyudmyla Kedenko, Margot Haun, Marie Metzger, Mark Woodward, Matthew J Hoffman, Matthias Nauck, Melanie Waldenberger, Menno Pruijm, Murielle Bochud, Myriam Rheinberger, Niek Verweij, Nicholas J Wareham, Nicole Endlich, Nicole Soranzo, Ozren Polasek, Pim van der Harst, Peter Paul Pramstaller, Peter Vollenweider, Philipp S Wild, Ron T Gansevoort, Rainer Rettig, Reiner Biffar, Robert J Carroll, Ronit Katz, Ruth J F Loos, Shih-Jen Hwang, Stefan Coassin, Sven Bergmann, Sylvia E Rosas, Sylvia Stracke, Tamara B Harris, Tanguy Corre, Tanja Zeller, Thomas Illig, Thor Aspelund, Toshiko Tanaka, Uwe Lendeckel, Uwe Völker, Vilmundur Gudnason, Vincent Chouraki, Wolfgang Koenig, Zoltan Kutalik, Jeffrey R O'Connell, Afshin Parsa, Iris M Heid, Andrew D Paterson, Ian H de Boer, Olivier Devuyst, Jozef Lazar, Karlhans Endlich, Katalin Susztak, Johanne Tremblay, Pavel Hamet, Howard Jacob, Carsten A Böger, Caroline S Fox, Cristian Pattaro, and Anna Köttgen

    Diabetes 65(3):803 (2016) PMID 26631737 PMCID PMC4764151

    Elevated concentrations of albumin in the urine, albuminuria, are a hallmark of diabetic kidney disease and are associated with an increased risk for end-stage renal disease and cardiovascular events. To gain insight into the pathophysiological mechanisms underlying albuminuria, we conducted met...
  17. The Greeks in the West: genetic signatures of the Hellenic colonisation in southern Italy and Sicily.

    European Journal of Human Genetics 24(3):429 (2016) PMID 26173964 PMCID PMC4757772

    Greek colonisation of South Italy and Sicily (Magna Graecia) was a defining event in European cultural history, although the demographic processes and genetic impacts involved have not been systematically investigated. Here, we combine high-resolution surveys of the variability at the uni-parent...
  18. Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium.
    Stéphanie M van den Berg, Marleen H de Moor, Karin J H Verweij, Robert F Krueger, Michelle Luciano, Alejandro Arias Vasquez, Lindsay K Matteson, Jaime Derringer, Tõnu Esko, Najaf Amin, Scott D Gordon, Narelle K Hansell, Amy B Hart, Ilkka Seppälä, Jennifer E Huffman, Bettina Konte, Jari Lahti, Minyoung Lee, Mike Miller, Teresa Nutile, Toshiko Tanaka, Alexander Teumer, Alexander Viktorin, Juho Wedenoja, Abdel Abdellaoui, Goncalo R Abecasis, Daniel E Adkins, Arpana Agrawal, Jüri Allik, Katja Appel, Timothy Bigdeli, Fabio Busonero, Harry Campbell, Paul T Costa, George Davey Smith, Gail Davies, Harriet de Wit, Jun Ding, Barbara Engelhardt, Johan G Eriksson, Iryna O Fedko, Luigi Ferrucci, Barbara Franke, Ina Giegling, Richard Grucza, Annette M Hartmann, Andrew C Heath, Kati Heinonen, Anjali K Henders, Georg Homuth, Hottenga, William G Iacono, Joost Janzing, Markus Jokela, Robert Karlsson, John P Kemp, Matthew G Kirkpatrick, Antti Latvala, Terho Lehtimäki, David C Liewald, Pamela A F Madden, Chiara Magri, Patrik K E Magnusson, Jonathan Marten, Andrea Maschio, Hamdi Mbarek, Sarah E Medland, Evelin Mihailov, Yuri Milaneschi, Grant W Montgomery, Matthias Nauck, Michel G Nivard, Klaasjan G Ouwens, Aarno Palotie, Erik Pettersson, Ozren Polasek, Yong Qian, Laura Pulkki-Råback, Olli T Raitakari, Anu Realo, Richard J Rose, Daniela Ruggiero, Carsten O Schmidt, Wendy Slutske, Rossella Sorice, John M Starr, Beate St Pourcain, Angelina R Sutin, Nicholas J Timpson, Holly Trochet, Sita Vermeulen, Eero Vuoksimaa, Elisabeth Widen, Jasper Wouda, Margaret J Wright, Lina Zgaga, David Porteous, Alessandra Minelli, Abraham Palmer, Dan Rujescu, Marina Ciullo, Caroline Hayward, Igor Rudan, Andres Metspalu, Jaakko Kaprio, Ian J Deary, Katri Räikkönen, James F Wilson, Liisa Keltikangas-Järvinen, Laura J Bierut, John M Hettema, Hans J Grabe, Brenda W J H Penninx, Cornelia M van Duijn, David M Evans, David Schlessinger, Nancy L Pedersen, Antonio Terracciano, Matt McGue, Nicholas G Martin, and Dorret I Boomsma

    Behavior Genetics 46(2):170 (2016) PMID 26362575 PMCID PMC4751159

    Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively...
  19. A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration.
    Paul S de Vries, Daniel I Chasman, Maria Sabater-Lleal, Ming-Huei Chen, Jennifer E Huffman, Maristella Steri, Weihong Tang, Alexander Teumer, Riccardo E Marioni, Vera Grossmann, Jouke Hottenga, Stella Trompet, Martina Müller-Nurasyid, Jing Hua Zhao, Jennifer A Brody, Marcus E Kleber, Xiuqing Guo, Jie Jin Wang, Paul L Auer, John R Attia, Lisa R Yanek, Tarunveer S Ahluwalia, Jari Lahti, Cristina Venturini, Toshiko Tanaka, Lawrence F Bielak, Peter K Joshi, Ares Rocanin-Arjo, Ivana Kolcic, Pau Navarro, Lynda M Rose, Christopher Oldmeadow, Helene Riess, Johanna Mazur, Saonli Basu, Anuj Goel, Qiong Yang, Mohsen Ghanbari, Gonneke Willemsen, Ann Rumley, Edoardo Fiorillo, Anton J M de Craen, Anne Grotevendt, Robert Scott, Kent D Taylor, Graciela E Delgado, Jie Yao, Annette Kifley, Charles Kooperberg, Rehan Qayyum, Lorna M Lopez, Tina L Berentzen, Katri Räikkönen, Massimo Mangino, Stefania Bandinelli, Patricia A Peyser, Sarah Wild, David-Alexandre Trégouët, Alan F Wright, Jonathan Marten, Tatijana Zemunik, Alanna C Morrison, Bengt Sennblad, Geoffrey Tofler, Moniek P de Maat, Eco J C de Geus, Gordon D Lowe, Magdalena Zoledziewska, Naveed Sattar, Harald Binder, Uwe Völker, Melanie Waldenberger, Kay-Tee Khaw, Barbara Mcknight, Jie Huang, Nancy S Jenny, Elizabeth G Holliday, Lihong Qi, Mark G Mcevoy, Diane M Becker, John M Starr, Antti-Pekka Sarin, Pirro G Hysi, Dena G Hernandez, Min A Jhun, Harry Campbell, Anders Hamsten, Fernando Rivadeneira, Wendy L Mcardle, P Eline Slagboom, Tanja Zeller, Wolfgang Koenig, Bruce M Psaty, Talin Haritunians, Jingmin Liu, Aarno Palotie, André G Uitterlinden, David J Stott, Albert Hofman, Oscar H Franco, Ozren Polasek, Igor Rudan, Pierre-Emmanuel Morange, James F Wilson, Sharon L R Kardia, Luigi Ferrucci, Tim D Spector, Johan G Eriksson, Torben Hansen, Ian J Deary, Lewis C Becker, Rodney J Scott, Paul Mitchell, Winfried März, Nick J Wareham, Annette Peters, Andreas Greinacher, Philipp S Wild, Wouter Jukema, Dorret I Boomsma, Caroline Hayward, Francesco Cucca, Russell Tracy, Hugh Watkins, Alex P Reiner, Aaron R Folsom, Paul M Ridker, Christopher J O'Donnell, Nicholas L Smith, David P Strachan, and Abbas Dehghan

    Human Molecular Genetics 25(2):358 (2016) PMID 26561523 PMCID PMC4715256

    Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X-chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels. ...
  20. Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.
    Cristian Pattaro, Alexander Teumer, Mathias Gorski, Audrey Y Chu, Man Li, Vladan Mijatovic, Maija Garnaas, Adrienne Tin, Rossella Sorice, Yong Li, Daniel Taliun, Matthias Olden, Meredith Foster, Qiong Yang, Ming-Huei Chen, Tune H Pers, Andrew D Johnson, Yi-An Ko, Christian Fuchsberger, Bamidele Tayo, Michael Nalls, Mary Feitosa, Aaron Isaacs, Abbas Dehghan, Pio, Adebowale Adeyemo, Aida Karina Dieffenbach, Alan B Zonderman, Ilja M Nolte, Peter J van der Most, Alan F Wright, Alan R Shuldiner, Alanna C Morrison, Albert Hofman, Albert V Smith, Albert W Dreisbach, Andre Franke, Andre G Uitterlinden, Andres Metspalu, Anke Tonjes, Antonio Lupo, Antonietta Robino, Åsa Johansson, Ayse Demirkan, Barbara Kollerits, Barry I Freedman, Belen Ponte, Ben A Oostra, Bernhard Paulweber, Bernhard Krämer, Braxton D Mitchell, Brendan M Buckley, Carmen A Peralta, Caroline Hayward, Catherine Helmer, Charles N Rotimi, Christian M Shaffer, Christian Müller, Cinzia Sala, Cornelia M van Duijn, Aude Saint-Pierre, Daniel Ackermann, Daniel Shriner, Daniela Ruggiero, Daniela Toniolo, Yingchang Lu, Daniele Cusi, Darina Czamara, David Ellinghaus, David Siscovick, Douglas Ruderfer, Christian Gieger, Harald Grallert, Elena Rochtchina, Elizabeth J Atkinson, Elizabeth G Holliday, Eric Boerwinkle, Erika Salvi, Erwin P Bottinger, Federico Murgia, Fernando Rivadeneira, Florian Ernst, Florian Kronenberg, Frank B Hu, Gerjan J Navis, Gary Curhan, George B Ehret, Georg Homuth, Stefan Coassin, Gian-Andri Thun, Giorgio Pistis, Giovanni Gambaro, Giovanni Malerba, Grant W Montgomery, Gudny Eiriksdottir, Gunnar Jacobs, Guo Li, H-Erich Wichmann, Harry Campbell, Helena Schmidt, Henri Wallaschofski, Henry Völzke, Hermann Brenner, Heyo Kroemer, Holly Kramer, Honghuang Lin, I Mateo Leach, Ian Ford, Idris Guessous, Igor Rudan, Inga Prokopenko, Ingrid Borecki, Iris M Heid, Ivana Kolcic, Ivana Persico, Wouter Jukema, James F Wilson, Janine Felix, Jasmin Divers, Jean-Charles Lambert, Jeanette M Stafford, Jean-Michel Gaspoz, Jennifer A Smith, Jessica D Faul, Jie Jin Wang, Jingzhong Ding, Joel N Hirschhorn, John Attia, John B Whitfield, John Chalmers, Jorma Viikari, Josef Coresh, Joshua C Denny, Juha Karjalainen, Jyotika K Fernandes, Karlhans Endlich, Katja Butterbach, Keith L Keene, Kurt Lohman, Laura Portas, Lenore J Launer, Leo-Pekka Lyytikäinen, Loic Yengo, Lude Franke, Luigi Ferrucci, Lynda M Rose, Lyudmyla Kedenko, Madhumathi Rao, Maksim Struchalin, Marcus E Kleber, Margherita Cavalieri, Margot Haun, Marilyn Cornelis, Marina Ciullo, Mario Pirastu, Mariza de Andrade, Mark A McEvoy, Mark Woodward, Martin Adam, Massimiliano Cocca, Matthias Nauck, Medea Imboden, Melanie Waldenberger, Menno Pruijm, Marie Metzger, Michael Stumvoll, Michele K Evans, Michele Sale, Mika Kähönen, Mladen Boban, Murielle Bochud, Myriam Rheinberger, Niek Verweij, Nabila Bouatia-Naji, Nicholas G Martin, Nick Hastie, Nicole Probst-Hensch, Nicole Soranzo, Olivier Devuyst, Olli Raitakari, Omri Gottesman, Oscar H Franco, Ozren Polasek, Paolo Gasparini, Patricia B Munroe, Paul M Ridker, Paul Mitchell, Paul Muntner, Christa Meisinger, Johannes H Smit, Peter Kovacs, Philipp S Wild, Philippe Froguel, Rainer Rettig, Reedik Mägi, Reiner Biffar, Reinhold Schmidt, Rita P S Middelberg, Robert J Carroll, Brenda W Penninx, Rodney J Scott, Ronit Katz, Sanaz Sedaghat, Sarah H Wild, Sharon L R Kardia, Sheila Ulivi, Shih-Jen Hwang, Stefan Enroth, Stefan Kloiber, Stella Trompet, Benedicte Stengel, Stephen J Hancock, Stephen Turner, Sylvia E Rosas, Sylvia Stracke, Tamara B Harris, Tanja Zeller, Tatijana Zemunik, Terho Lehtimäki, Thomas Illig, Thor Aspelund, Tiit Nikopensius, Tonu Esko, Toshiko Tanaka, Ulf Gyllensten, Uwe Völker, Valur Emilsson, Veronique Vitart, Ville Aalto, Vilmundur Gudnason, Vincent Chouraki, Wei-Min Chen, Wilmar Igl, Winfried März, Wolfgang Koenig, Wolfgang Lieb, Ruth J F Loos, Yongmei Liu, Harold Snieder, Peter Pramstaller, Afshin Parsa, Jeffrey R O'Connell, Katalin Susztak, Pavel Hamet, Johanne Tremblay, Ian H de Boer, Carsten A Böger, Wolfram Goessling, Daniel I Chasman, Anna Köttgen, W H Linda Kao, and Caroline S Fox

    Nature Communications 7:10023 (2016) PMID 26831199 PMCID PMC4735748

    Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replica...