1. Invasive Pneumococcal Disease Among Immunocompromised Persons: Implications for Vaccination Programs.

    Clinical Infectious Diseases 62(2):139 (2016) PMID 26354970

    In 2012/2013, a single dose of 13-valent pneumococcal conjugate vaccine (PCV13) was recommended for immunocompromised adults in the United States and Canada. To assess the potential benefits of this recommendation, we assessed the serotype-specific burden of invasive pneumococcal disease (IPD) a...
  2. Culture-positive Pediatric Tuberculosis in Toronto, Ontario: Sources of Infection and Relationship of Birthplace and Mycobacterial Lineage to Phenotype.

    Pediatric Infectious Disease Journal 35(1):13 (2016) PMID 26379168

    Few data relate Mycobacterium tuberculosis (Mtb) lineage and disease phenotype in the pediatric population or examine the contribution of travel to the tuberculosis (TB)-endemic country in North America. We examined clinical, demographic and Mtb genotype data from patients with TB who were treat...
  3. Nonresponding osteomyelitis in a two-year-old boy.

    Canadian Medical Association Journal 187(12):901 (2015) PMID 25918176 PMCID PMC4562829

  4. Relating Tuberculosis (TB) Contact Characteristics to QuantiFERON-TB-Gold and Tuberculin Skin Test Results in the Toronto Pediatric TB Clinic.

    Journal of the Pediatric Infectious Diseases So... 4(2):96 (2015) PMID 26407408

    Few data relate interferon-γ-release-assay results in children to source case sputum status, the best predictor of infectiousness of tuberculosis (TB) patients. We evaluated the QuantiFERON-Gold-in-tube assay (QFT) and tuberculin skin test (TST) in children with different types of TB exposure. T...
  5. Epidemiology and clinical management of tuberculosis in children in Canada.

    Paediatrics & child health 20(2):83 (2015) PMID 25838781 PMCID PMC4373581

    Although often regarded as a foreign disease, latent tuberculosis or tuberculosis disease will be encountered in many clinical situations by the Canadian child health practitioner. There are key differences between tuberculosis in children and adults. In the present article, the changing epidemi...
  6. Utility of gastric aspirates for diagnosing tuberculosis in children in a low prevalence area: predictors of positive cultures and significance of non-tuberculous mycobacteria.

    Pediatric Infectious Disease Journal 34(1):91 (2015) PMID 25101762

    In countries with low rates of tuberculosis (TB), yields of gastric aspirates (GAs) for Mycobacterium tuberculosis (MTB) culture are low. The significance of non-tuberculous mycobacteria (NTM) isolated from GA is uncertain. We reviewed clinical, microbiologic and radiologic data for children who...
  7. Rifampin hypersensitivity in a 2-year-old child with successful rapid oral desensitization.

    Pediatric Infectious Disease Journal 33(7):787 (2014) PMID 24918746

  8. Encounters with an old foe: Childhood tuberculosis in Canada.

    Paediatrics & child health 19(2):89 (2014) PMID 24596483 PMCID PMC3941674

  9. Quantiferon Gold-in-tube assay for TB screening in HIV infected children: influence of quantitative values.

    BMC Infectious Diseases 14:516 (2014) PMID 25248406 PMCID PMC4181619

    HIV infected children are at increased risk of TB disease and require annual TB screening. Data on use of IGRA for TB screening in them are limited. We retrospectively evaluated the usefulness of Quantiferon Gold-in-tube test (QFT), an IGRA in screening for LTBI in relatively healthy, immunologi...
  10. Pneumococcal vaccination programs and the burden of invasive pneumococcal disease in Ontario, Canada, 1995-2011.

    Vaccine 31(49):5863 (2013) PMID 24099873

    In 1995, a publicly funded pneumococcal vaccination program for 23-valent polysaccharide vaccine (PPV23) was introduced in Ontario. Conjugate vaccines were authorized in 2001 (PCV7), 2009 (PCV10) and 2010 (PCV13). From 1995-2011, active, population-based surveillance for invasive pneumococcal di...
  11. Isoniazid toxicity in a 5-year-old boy.

    Canadian Medical Association Journal 185(10):894 (2013) PMID 23670154 PMCID PMC3707995

  12. Case 2: Monoarthritis in a four-year-old child.

    Paediatrics & child health 17(7):387 (2012) PMID 23904785 PMCID PMC3448542

  13. Unexplained deterioration during antituberculous therapy in children and adolescents: clinical presentation and risk factors.

    Pediatric Infectious Disease Journal 31(2):129 (2012) PMID 22016079

    Patients may unexpectedly deteriorate clinically and/or radiographically during the course of appropriate treatment for tuberculosis. These events have been extensively studied in human immunodeficiency virus-positive patients; however, there are few data about immunocompetent children and adole...
  14. Tuberculosis: evidence review for newly arriving immigrants and refugees.

    Canadian Medical Association Journal 183(12):E939 (2011) PMID 20634392 PMCID PMC3168670

    The foreign-born population bears a disproportionate health burden from tuberculosis, with a rate of active tuberculosis 20 times that of the non-Aboriginal Canadian-born population, and could therefore benefit from tuberculosis screening programs. We reviewed evidence to determine the burden of...
  15. Drug-resistant tuberculosis: pediatric guidelines.

    Pediatric Infectious Disease Journal 30(6):501 (2011) PMID 21297522

    Drug-resistant Mycobacterium tuberculosis (TB) infection represents a serious and growing problem. For patients infected or suspected of being infected with multidrug or extensively drug-resistant TB, several medications have to be given simultaneously for prolonged periods. Here, we review the ...
  16. Sporotrichoid-like tuberculosis.

    Pediatric Infectious Disease Journal 28(12):1135 (2009) PMID 19773674

    Cutaneous tuberculosis (TB) is a rare presentation of tuberculosis infection in childhood, especially in developed countries. The commonest forms of cutaneous TB, in declining order, are scrofuloderma, lupus vulgaris, lichen scrofulosorum, and TB verrucosa cutis. We described 2 cases of sporotri...
  17. A population-based study of tuberculosis in children and adolescents in Ontario.

    Pediatric Infectious Disease Journal 28(5):416 (2009) PMID 19352212

    There are few population-based data on presentation and treatment of tuberculosis (TB) in children and adolescents in Ontario. We analyzed data from 121 patients less than 17 years of age with TB disease reported to the Province of Ontario between 1999 and 2002. Physician provider data were obta...
  18. Neuroimaging findings in isoniazid central nervous system toxicity, presumed intramyelinic edema.

    European Journal of Paediatric Neurology 12(6):512 (2008) PMID 18243740

    We describe the clinical course and striking neuroimaging findings of a child with central nervous system toxicity due to isoniazid. Serum isoniazid level was in the toxic range, the result of a dispensing error as well as a possible pharmacogenetic factor. We postulate that these imaging findin...
  19. Active tuberculosis among adolescents in toronto, Canada: clinical features and delays in diagnosis.

    Pediatric Infectious Disease Journal 26(4):355 (2007) PMID 17414403

    There are few studies on tuberculosis (TB) in adolescents. During a 6-year period, 23 adolescents were treated for TB in our center. Most were foreign born. The average time from symptom onset to final diagnosis was 5.2 months. Multifocal and extra pulmonary disease occurred in the majority of p...
  20. Nosocomial transmission of congenital tuberculosis in a neonatal intensive care unit.

    Clinical Infectious Diseases 39(11):1719 (2004) PMID 15578377

    Congenital tuberculosis is uncommon, and nosocomial transmission from a congenitally infected infant to another infant has not been reported in the English literature. We report an investigation of 2 infants with tuberculosis who were cared for in the same neonatal intensive care unit. Isolates ...