1. An image-based genetic assay identifies genes in T1D susceptibility loci controlling cellular antiviral immunity in mouse.

    PLoS ONE 9(9):e108777 (2014) PMID 25268627 PMCID PMC4182575

    The pathogenesis of complex diseases, such as type 1 diabetes (T1D), derives from interactions between host genetics and environmental factors. Previous studies have suggested that viral infection plays a significant role in initiation of T1D in genetically predisposed individuals. T1D susceptib...
  2. Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection.

    Gastroenterology 145(6):1347 (2013) PMID 23973919 PMCID PMC3840157

    Intestinal epithelial cells aid in mucosal defense by providing a physical barrier against entry of pathogenic bacteria and secreting antimicrobial peptides (AMPs). Autophagy is an important component of immune homeostasis. However, little is known about its role in specific cell types during ba...
  3. Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection.

    Gastroenterology 145(6):1347 (2013) PMID 23973919 PMCID PMC3840157

    Intestinal epithelial cells aid in mucosal defense by providing a physical barrier against entry of pathogenic bacteria and secreting antimicrobial peptides (AMPs). Autophagy is an important component of immune homeostasis. However, little is known about its role in specific cell types during ba...
  4. Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection.

    Gastroenterology 145(6):1347 (2013) PMID 23973919 PMCID PMC3840157

    Intestinal epithelial cells aid in mucosal defense by providing a physical barrier against entry of pathogenic bacteria and secreting antimicrobial peptides (AMPs). Autophagy is an important component of immune homeostasis. However, little is known about its role in specific cell types during ba...
  5. Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection.

    Gastroenterology 145(6):1347 (2013) PMID 23973919 PMCID PMC3840157

    Intestinal epithelial cells aid in mucosal defense by providing a physical barrier against entry of pathogenic bacteria and secreting antimicrobial peptides (AMPs). Autophagy is an important component of immune homeostasis. However, little is known about its role in specific cell types during ba...
  6. AMP-activated protein kinase is a positive regulator of poly(ADP-ribose) polymerase.

    Biochemical and Biophysical Research Communicat... 342(1):336 (2006) PMID 16480959

    AMPK acts as a cellular fuel gauge and responds to decreased cellular energy status by inhibiting ATP-consuming pathways and increasing ATP-synthesis. The aim of this study was to examine the role of AMPK in modulating poly(ADP-ribose) polymerase (PARP), a nuclear enzyme involved in maintaining ...
  7. Adenosine is a negative regulator of NF-kappaB and MAPK signaling in human intestinal epithelial cells.

    Cellular Immunology 237(2):86 (2005) PMID 16413516

    Previous studies suggest that adenosine possesses anti-inflammatory properties, however, the mechanisms by which adenosine affects immune function remain unclear, particularly in the intestine. In this study, we hypothesized that adenosine directly affects pro-inflammatory gene expression in int...
  8. Mechanisms of omega-3 fatty acid-induced growth inhibition in MDA-MB-231 human breast cancer cells.

    Breast Cancer Research and Treatment 92(2):187 (2005) PMID 15986129

    The omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), inhibit the growth of human breast cancer cells in animal models and cell lines, but the mechanism by which this occurs is not well understood. In order to explore possible mechanisms for the modulation of breas...
  9. Serum amyloid A activates NF-kappaB and proinflammatory gene expression in human and murine intestinal epithelial cells.

    European Journal of Immunology 35(3):718 (2005) PMID 15724247

    Serum amyloid A (SAA) is an acute-phase protein whose levels positively correlate with disease activity in inflammatory bowel diseases. In this study we investigated the impact of SAA on NF-kappaB signaling and proinflammatory gene expression in intestinal epithelial cells (IEC). Human HT-29 and...
  10. 5-aminoimidazole-4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal glucose transport: a possible role for AMPK.

    Biochemical Journal 385(Pt 2):485 (2005) PMID 15367103 PMCID PMC1134720

    AMPK (AMP-activated protein kinase) is a key sensor of energy status within the cell. Activated by an increase in the AMP/ATP ratio, AMPK acts to limit cellular energy depletion by down-regulating selective ATP-dependent processes. The purpose of the present study was to determine the role of AM...
  11. 5-aminoimidazole-4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal glucose transport: a possible role for AMPK.

    Biochemical Journal 385(Pt 2):485 (2005) PMID 15367103 PMCID PMC1134720

    AMPK (AMP-activated protein kinase) is a key sensor of energy status within the cell. Activated by an increase in the AMP/ATP ratio, AMPK acts to limit cellular energy depletion by down-regulating selective ATP-dependent processes. The purpose of the present study was to determine the role of AM...
  12. Activation of AMP-activated protein kinase reduces cAMP-mediated epithelial chloride secretion.

    American Journal of Physiology - Gastrointestin... 285(5):G850 (2003) PMID 12869384

    AMP-activated protein kinase (AMPK) is activated in response to fluctuations in cellular energy status caused by oxidative stress. One of its targets is the cystic fibrosis transmembrane conductance regulator (CFTR), which is the predominant Cl- secretory channel in colonic tissue. The aim of th...
  13. MAP kinases contribute to IL-8 secretion by intestinal epithelial cells via a posttranscriptional mechanism.

    American Journal of Physiology - Cell Physiology 283(1):C31 (2002) PMID 12055070

    The intracellular pathways that regulate intestinal epithelial gene expression are poorly understood. In this study we examined the roles of extracellular signal-regulated kinase (ERK) and p38 in the expression of interleukin-8 (IL-8) and intercellular adhesion molecule-1 (ICAM-1) using the huma...
  14. MAP kinases contribute to IL-8 secretion by intestinal epithelial cells via a posttranscriptional mechanism.

    American Journal of Physiology - Cell Physiology 283(1):C31 (2002) PMID 12055070

    The intracellular pathways that regulate intestinal epithelial gene expression are poorly understood. In this study we examined the roles of extracellular signal-regulated kinase (ERK) and p38 in the expression of interleukin-8 (IL-8) and intercellular adhesion molecule-1 (ICAM-1) using the huma...