A novel mast cell co-culture microfluidic chip for the electrochemical evaluation of food allergen.
Biosensors and Bioelectronics 83:126 (2016)
In this study a novel cell-to-cell electrochemical microfluidic chip was developed for qualitative and quantitative analysis of food allergen. Microfluidic cell culture, food allergen-induced cell morphological changes, and cell metabolism measurements were performed simultaneously using the afo...
Screening and functional analysis of differentially expressed genes in chronic glomerulonephritis by whole genome microarray.
Gene 589(1):72 (2016)
Chronic glomerulonephritis (CGN) is the most common form of the glomerular disease with unclear molecular mechanisms, which related to immune-mediated inflammatory diseases. The aim of this study was to characterize differentially expressed genes in the normal and adriamycin-induced CGN rats by ...
Complete mitochondrial genome of the Saker falcon, Falco cherrug (Falco, Falconidae).
Mitochondrial DNA Part A 27(5):3226 (2016)
The Falco cherrug (Saker falcon) is a large bird of prey. In this article, the complete mitochondrial genome of F. cherrug has been determined for the first time. The mitogenome (18,059 bp) comprised 13 protein-coding genes, 22 tRNA genes, 2 rRNA genes and 1 control region. Most protein-coding g...
Urinary metabolite profiling provides potential differentiation to explore the mechanisms of adjuvant-induced arthritis in rats.
Biomedical Chromatography 30(9):1397 (2016)
To explore the pathogenesis of rheumatoid arthritis (RA) from the perspective of metabolomics, gas chromatography time-of-flight mass spectrometry (GC-TOF/MS) technology was used to observe changes in the metabolic profiles of urine output from rats with adjuvant-induced arthritis (AA). Sprague-...
A novel nonenzymatic biosensor for evaluation of oxidative stress based on nanocomposites of graphene blended with CuI.
Analytica Chimica Acta 933:66 (2016)
A high-sensitive nonenzymatic hydrogen peroxide (H2O2) biosensor based on cuprous iodide and graphene (CuI/Gr) composites has been explored for the detection of H2O2 released by living cells and monitoring the oxidative stress of cells under excellular stimulation. The biosensor properties were ...
Grasses suppress shoot-borne roots to conserve water during drought.
PNAS 113(31):8861 (2016)
Many important crops are members of the Poaceae family, which develop root systems characterized by a high degree of root initiation from the belowground basal nodes of the shoot, termed the crown. Although this postembryonic shoot-borne root system represents the major conduit for water uptake,...
A Recombinant DNA Plasmid Encoding the sIL-4R-NAP Fusion Protein Suppress Airway Inflammation in an OVA-Induced Mouse Model of Asthma.
Inflammation 39(4):1434 (2016)
Asthma is a chronic inflammatory airway disease. It was prevalently perceived that Th2 cells played the crucial role in asthma pathogenesis, which has been identified as the important target for anti-asthma therapy. The soluble IL-4 receptor (sIL-4R), which is the decoy receptor for Th2 cytokine...
In vivo target bio-imaging of Alzheimer's disease by fluorescent zinc oxide nanoclusters.
Biomaterials Science 4(7):1085 (2016)
Alzheimer's disease (AD) is an irreversible neurodegenerative disease which is difficult to cure. When Alzheimer's disease occurs, the level of zinc ions in the brain changes, and the relevant amount of zinc ions continue decreasing in the cerebrospinal fluid and plasma of Alzheimer's patients w...
A Small Molecule That Protects the Integrity of the Electron Transfer Chain Blocks the Mitochondrial Apoptotic Pathway.
Molecular Cell 63(2):229 (2016)
In response to apoptotic stimuli, mitochondria in mammalian cells release cytochrome c and other apoptogenic proteins, leading to the subsequent activation of caspases and apoptotic cell death. This process is promoted by the pro-apoptotic members of the Bcl-2 family of proteins, such as Bim and...
A Sensitive and simple macrophage-based electrochemical biosensor for evaluating lipopolysaccharide cytotoxicity of pathogenic bacteria.
Biosensors and Bioelectronics 81:349 (2016)
In this study, a sensitive and simple electrochemical murine macrophage (Ana-1) cell sensor has been developed for early detection of lipopolysaccharides (LPS) to evaluate the toxicity of pathogenic bacteria. Magnetic glassy carbon electrode (MGCE), which possesses excellent reproducibility and ...
Deep sequencing of the MHC region in the Chinese population contributes to studies of complex disease.
Nature Genetics 48(7):740 (2016)
The human major histocompatibility complex (MHC) region has been shown to be associated with numerous diseases. However, it remains a challenge to pinpoint the causal variants for these associations because of the extreme complexity of the region. We thus sequenced the entire 5-Mb MHC region in ...
Global epidemiology of avian influenza A H5N1 virus infection in humans, 1997-2015: a systematic review of individual case data.
The Lancet Infectious Diseases 16(7):e108 (2016)
Avian influenza A H5N1 viruses have caused many, typically severe, human infections since the first human case was reported in 1997. However, no comprehensive epidemiological analysis of global human cases of H5N1 from 1997 to 2015 exists. Moreover, few studies have examined in detail the changi...
Whole-Exome Sequencing Reveals Increased Burden of Rare Functional and Disruptive Variants in Candidate Risk Genes in Individuals With Persistent Attention-Deficit/Hyperactivity Disorder.
Journal of the American Academy of Child & Adol... 55(6):521 (2016)
miR-491-5p suppresses cell growth and invasion by targeting Notch3 in nasopharyngeal carcinoma.
Oncology Reports 35(6):3541 (2016)
MicroRNAs (miRNAs) have critical roles in the progression of nasopharyngeal carcinoma (NPC), a highly invasive and metastatic cancer that is widely prevalent in Southern China. miR-491-5p has been implicated in multiple types of cancer; however, its biological role and underlying mechanism in NP...
Homozygous GNAL mutation associated with familial childhood-onset generalized dystonia.
Neurology Genetics 2(3):e78 (2016)
Concurrent nuclear ERG and MYC protein overexpression defines a subset of locally advanced prostate cancer: Potential opportunities for synergistic targeted therapeutics.
Prostate 76(9):845 (2016)
Recurrent ERG gene fusions, the most common genetic alterations in prostate cancer, drive overexpression of the nuclear transcription factor ERG, and are early clonal events in prostate cancer progression. The nuclear transcription factor MYC is also frequently overexpressed in prostate cancer a...
Human Infection with Influenza A(H7N9) Virus during 3 Major Epidemic Waves, China, 2013-2015.
Emerging Infectious Diseases 22(6):964 (2016)
Since March 2013, a novel influenza A(H7N9) virus has caused 3 epidemic waves of human infection in mainland China. We analyzed data from patients with laboratory-confirmed influenza A(H7N9) virus infection to estimate the risks for severe outcomes after hospitalization across the 3 waves. We fo...
Multidisciplinary effort in treating children with hepatoblastoma in China.
Cancer Letters 375(1):39 (2016)
The purpose of this study is to report the first nationwide protocol (Wuhan Protocol) developed by Chinese Children's Cancer Group and the results of multidisciplinary effort in treating hepatoblastoma. In this study, we reported the final analysis, which includes 153 hepatoblastoma patients in ...
Unexpected Thiols Triggering Photoluminescent Enhancement of Cytidine Stabilized Au Nanoclusters for Sensitive Assays of Glutathione Reductase and Its Inhibitors Screening.
Analytical chemistry 88(9):4766 (2016)
The photoluminescence (PL) of nonthiolate ligand capped Au nanoclusters (NCs) is usually quenched by thiols due to the tight adsorption of thiols to the Au surface and formation of larger non-PL species. However, we here report an unexpected PL enhancement of cytidine stabilized Au (AuCyt) NCs t...
Differential regulation of the c-Myc/Lin28 axis discriminates subclasses of rearranged MLL leukemia.
Oncotarget 7(18):25208 (2016)
MLL rearrangements occur in myeloid and lymphoid leukemias and are generally associated with a poor prognosis, however this varies depending on the fusion partner. We modeled acute myeloid leukemia (AML) in mice using various MLL fusion proteins (MLL-FPs) and observed significantly different sur...