1. Detection of xeljanz enantiomers in diethyl amine active pharmaceutical ingredients and tablets.

    Chirality 27(3):235 (2015) PMID 25545065

    A high-performance liquid chromatography (HPLC) method was established to detect Xeljanz enantiomers in active pharmaceutical ingredients (APIs) and tablets. The separation was achieved on a Chiralpak IC column using a mobile phase of hexane-ethanol-diethylamine (65:35:0.1, v/v). The detection w...
  2. Fluorescent magnetic bead-based mast cell biosensor for electrochemical detection of allergens in foodstuffs.

    Biosensors and Bioelectronics 70:482 (2015) PMID 25889258

    In this study, a novel electrochemical rat basophilic leukemia cell (RBL-2H3) cell sensor, based on fluorescent magnetic beads, has been developed for the detection and evaluation of different allergens in foodstuffs. Fluorescein isothiocyanate (FITC) was successfully fused inside the SiO2 layer...
  3. Differences in the Epidemiology of Human Cases of Avian Influenza A(H7N9) and A(H5N1) Viruses Infection.

    Clinical Infectious Diseases 61(4):563 (2015) PMID 25940354

    The pandemic potential of avian influenza viruses A(H5N1) and A(H7N9) remains an unresolved but critically important question. We compared the characteristics of sporadic and clustered cases of human H5N1 and H7N9 infection, estimated the relative risk of infection in blood-related contacts, and...
  4. Plasma-enhanced microwave solid-state synthesis of cadmium sulfide: reaction mechanism and optical properties.

    Dalton Transactions (Print Edition) 44(30):13444 (2015) PMID 26151570

    CdS synthesis by plasma-enhanced microwave physical vapor transport (PMPVT) has been developed in this work. The photoluminescence (PL), absorbance, Raman spectra and the mechanism of CdS crystal growth have been investigated. Furthermore, plasma-enhanced microwave chemical vapour transport (PMC...
  5. Syntheses and structures of three transition metal coordination polymers based on 5-Aminonicotinic acid

    Journal of Molecular Structure 1091:25 (2015)

    Three new coordination polymers (CPs) based on rigid ligand 5-Aminonicotinic acid (5-anaH), [Cd(5-ana)2]·(H2O)2 (1), [Cd(5-ana)(HCOO)] (2) and [Cu(5-ana)2] (3), have been synthesized under different solvent media and temperatures. 1 is a 2D (4,4)-connected layered structure which conta...
  6. Correction to "Pregnancy-Induced Metabolic Phenotype Variations in Maternal Plasma".

    Journal of Proteome Research 14(7):3005 (2015) PMID 26035232

  7. Conditionally Increased Acoustic Pressures in Nonfetal Diagnostic Ultrasound Examinations Without Contrast Agents: A Preliminary Assessment.

    Journal of Ultrasound in Medicine 34(7):1 (2015) PMID 26112617

    The mechanical index (MI) has been used by the US Food and Drug Administration (FDA) since 1992 for regulatory decisions regarding the acoustic output of diagnostic ultrasound equipment. Its formula is based on predictions of acoustic cavitation under specific conditions. Since its implementatio...
  8. An acyltransferase domain of FK506 polyketide synthase recognizing both an acyl carrier protein and coenzyme A as acyl donors to transfer allylmalonyl and ethylmalonyl units.

    FEBS Journal 282(13):2527 (2015) PMID 25865045

    Acyltransferase (AT) domains of polyketide synthases (PKSs) usually use coenzyme A (CoA) as an acyl donor to transfer common acyl units to acyl carrier protein (ACP) domains, initiating incorporation of acyl units into polyketides. Two clinical immunosuppressive agents, FK506 and FK520, are bios...
  9. Functional annotation of cis-regulatory elements in human cells by dCas9/sgRNA.

    Cell Research 25(7):877 (2015) PMID 26045164 PMCID PMC4493279

  10. The c-Myc-LDHA axis positively regulates aerobic glycolysis and promotes tumor progression in pancreatic cancer.

    Medical Oncology 32(7):187 (2015) PMID 26021472 PMCID PMC4452209

    The transcription factor c-Myc plays critical roles in cancer development and progression through regulating expression of targeted genes. Lactate dehydrogenase A (LDHA), which catalyzes the conversion of L-lactate to pyruvate in the final step of anaerobic glycolysis, is frequently upregulated ...
  11. Association Between Dosage Frequency and the Treatment Outcomes of Sildenafil in Young and Middle-aged Men With Erectile Dysfunction: A Chinese, Multicenter, Observational Study.

    Urology 86(1):62 (2015) PMID 26142584

    To evaluate the correlation between the dosage frequency of sildenafil and its treatment outcomes in men with erectile dysfunction (ED). Data were from a 4-week, multicenter, observational study of men (1699), between 18 and 60 years of age, with a clinical diagnosis of ED defined as the Sexual ...
  12. rSeqNP: a non-parametric approach for detecting differential expression and splicing from RNA-Seq data.

    PMID 25717189 PMCID PMC4481847

    High-throughput sequencing of transcriptomes (RNA-Seq) has become a powerful tool to study gene expression. Here we present an R package, rSeqNP, which implements a non-parametric approach to test for differential expression and splicing from RNA-Seq data. rSeqNP uses permutation tests to access...
  13. snoRNA U17 Regulates Cellular Cholesterol Trafficking.

    Cell Metabolism 21(6):855 (2015) PMID 25980348 PMCID PMC4456254

    Cholesterol is required for the growth and viability of mammalian cells and is an obligate precursor for steroid hormone synthesis. Using a loss-of-function screen for mutants with defects in intracellular cholesterol trafficking, a Chinese hamster ovary cell mutant with haploinsufficiency of th...
  14. A validated LC-MS/MS assay for quantification of 24(S)-hydroxycholesterol in plasma and cerebrospinal fluid.

    Journal of Lipid Research 56(6):1222 (2015) PMID 25866316 PMCID PMC4442878

    24(S)-hydroxycholesterol [24(S)-HC] is a cholesterol metabolite that is formed almost exclusively in the brain. The concentrations of 24(S)-HC in cerebrospinal fluid (CSF) and/or plasma might be a sensitive marker of altered cholesterol metabolism in the CNS. A highly sensitive 2D-LC-MS/MS assay...
  15. Unique Variants in OPN1LW Cause Both Syndromic and Nonsyndromic X-Linked High Myopia Mapped to MYP1.

    Investigative Ophthalmology & Visual Science 56(6):4150 (2015) PMID 26114493

    MYP1 is a locus for X-linked syndromic and nonsyndromic high myopia. Recently, unique haplotypes in OPN1LW were found to be responsible for X-linked syndromic high myopia mapped to MYP1. The current study is to test if such variants in OPN1LW are also responsible for X-linked nonsyndromic high m...
  16. Performance of lateral flow device and galactomannan for the detection of Aspergillus species in bronchoalveolar fluid of patients at risk for invasive pulmonary aspergillosis.

    Mycoses 58(6):368 (2015) PMID 25996144

    Early diagnosis of invasive pulmonary aspergillosis (IPA) remains difficult due to the variable performance of the tests used. We compared the performance characteristics of Aspergillus lateral flow device (LFD) in bronchoalveolar lavage (BAL) vs. BAL-galactomannan (GM), for the diagnosis of IPA...
  17. Nurses' roles in direct nursing care delivery in China.

    Applied Nursing Research 28(2):132 (2015) PMID 25284092

    To study the nurses' roles in direct nursing care delivery in the neurology ward in China. As patients' demands for healthcare have increased, the quality of the nursing service has become a focus of attention. Nurses play an important role in the delivery of care and can affect the quality of p...
  18. Cytidine-stabilized gold nanocluster as a fluorescence turn-on and turn-off probe for dual functional detection of Ag(+) and Hg(2+).

    Analytica Chimica Acta 870:1 (2015) PMID 25819783

    In this study, we have developed a label-free, dual functional detection strategy for highly selective and sensitive determination of aqueous Ag(+) and Hg(2+) by using cytidine stabilized Au NCs and AuAg NCs as fluorescent turn-on and turn off probes, respectively. The Au NCs and AuAg NCs showed...
  19. Effect of Pore Structure on CO₂ Adsorption Characteristics of Aminopolymer Impregnated MCM-36.

    Langmuir 31(15):4534 (2015) PMID 25811242

    The CO2 adsorption characteristics of a pillared 2-dimensional porous silicate material impregnated with amine containing polymers have been investigated. It was determined that the introduction of amine polymer deteriorates the CO2 capture kinetics of the MCM-36 supported amine adsorbents compa...
  20. MiR-124 promotes bone marrow mesenchymal stem cells differentiation into neurogenic cells for accelerating recovery in the spinal cord injury.

    Tissue and Cell 47(2):140 (2015) PMID 25697062

    In this research, mouse BMMSCs were isolated from bone marrow, induced to differentiate into neurogenic cells in vitro, and transplanted into the injured spinal cord after over-expression of miR-124. The results showed that the BMMSCs could induce the differentiation to neurogenic cells under th...