1. The human studies database project: federating human studies design data using the ontology of clinical research.

    AMIA Summits on Translational Science proceedin... 2010:51 (2010) PMID 21347149 PMCID PMC3041546

    Human studies, encompassing interventional and observational studies, are the most important source of evidence for advancing our understanding of health, disease, and treatment options. To promote discovery, the design and results of these studies should be made machine-readable for large-scale...
  2. The human studies database project: federating human studies design data using the ontology of clinical research.

    AMIA Summits on Translational Science proceedin... 2010:51 (2010) PMID 21347149 PMCID PMC3041546

    Human studies, encompassing interventional and observational studies, are the most important source of evidence for advancing our understanding of health, disease, and treatment options. To promote discovery, the design and results of these studies should be made machine-readable for large-scale...
  3. Development and evaluation of a study design typology for human research.

    AMIA Symposium 2009:81 (2009) PMID 20351827 PMCID PMC2815479

    A systematic classification of study designs would be useful for researchers, systematic reviewers, readers, and research administrators, among others. As part of the Human Studies Database Project, we developed the Study Design Typology to standardize the classification of study designs in huma...
  4. Development and evaluation of a study design typology for human research.

    AMIA Symposium 2009:81 (2009) PMID 20351827 PMCID PMC2815479

    A systematic classification of study designs would be useful for researchers, systematic reviewers, readers, and research administrators, among others. As part of the Human Studies Database Project, we developed the Study Design Typology to standardize the classification of study designs in huma...
  5. Ultramicrotomy for biological electron microscopy.

    Methods in Molecular Biology 369:67 (2007) PMID 17656747

    This chapter describes the practical details involved in the successful sectioning of plastic-embedded specimens for electron microscopy. The focus will be on those parts of the process that are really key to the successful sectioning of any biological material, i.e., the proper shape and size o...
  6. Ultramicrotomy for biological electron microscopy.

    Methods in Molecular Biology 369:67 (2007) PMID 17656747

    This chapter describes the practical details involved in the successful sectioning of plastic-embedded specimens for electron microscopy. The focus will be on those parts of the process that are really key to the successful sectioning of any biological material, i.e., the proper shape and size o...
  7. Retinoic acid induces nonuniform alveolar septal growth after right pneumonectomy.

    Journal of Applied Physiology 96(3):1080 (2004) PMID 14617528

    To determine whether all-trans retinoic acid (RA) enhances compensatory lung growth in fully mature animals, adult male dogs (n = 4) received 2 mg x kg(-1) x day(-1) po RA 4 days/wk beginning the day after right pneumonectomy (R-PNX, 55-58% resection). Litter-matched male R-PNX controls (n = 4) ...
  8. Retinoic acid induces nonuniform alveolar septal growth after right pneumonectomy.

    Journal of Applied Physiology 96(3):1080 (2004) PMID 14617528

    To determine whether all-trans retinoic acid (RA) enhances compensatory lung growth in fully mature animals, adult male dogs (n = 4) received 2 mg x kg(-1) x day(-1) po RA 4 days/wk beginning the day after right pneumonectomy (R-PNX, 55-58% resection). Litter-matched male R-PNX controls (n = 4) ...
  9. How e-mail raises the spectre of a digital Dark Age.

    Nature 423(6942):801 (2003) PMID 12815399

  10. How e-mail raises the spectre of a digital Dark Age.

    Nature 423(6942):801 (2003) PMID 12815399

  11. Expression of epidermal growth factor and surfactant proteins during postnatal and compensatory lung growth.

    American Journal of Physiology - Lung Cellular ... 283(5):L981 (2002) PMID 12376351

    We examined whether lung growth after pneumonectomy (PNX) invokes normal signaling pathways of postnatal development. We qualitatively and quantitatively assessed the immunoexpression of epidermal growth factor (EGF), its receptor (EGFR), surfactant proteins (SP) [SP-A and -D and surfactant prop...
  12. Expression of epidermal growth factor and surfactant proteins during postnatal and compensatory lung growth.

    American Journal of Physiology - Lung Cellular ... 283(5):L981 (2002) PMID 12376351

    We examined whether lung growth after pneumonectomy (PNX) invokes normal signaling pathways of postnatal development. We qualitatively and quantitatively assessed the immunoexpression of epidermal growth factor (EGF), its receptor (EGFR), surfactant proteins (SP) [SP-A and -D and surfactant prop...
  13. Exposure of isolated adult rat cardiac myocytes to oxygen-derived free radicals initiates alterations in intracellular ionic calcium levels

    Journal of Molecular and Cellular Cardiology 23:S40 (1991)

  14. Developments in cryo-ultramicrotomy

    Micron and Microscopica Acta 22(1):45 (1991)

  15. Free radicals alter ionic calcium levels and membrane phospholipids in cultured rat ventricular myocytes

    Journal of Molecular and Cellular Cardiology 22(9):1035 (1990)

    Oxygen-derived free radicals have been implicated in damage to membrane phospholipids leading to alterations in membrane function. The purpose of this study was to investigate alterations in intracellular ionic calcium (Ca 2+) levels and Ca 2+ transients, cellular morphology, co...
  16. Porous hydroxylapatite as a bone graft substitute in mandibular contour augmentation: A histometric study

    Journal of Oral and Maxillofacial Surgery 45(5):421 (1987)

    The buccal contour of the mandible was augmented in 17 dogs with 5 × 7.5 × 20 mm blocks of porous hydroxylapatite (HA) on one side and two-layered split rib autografts on the other. Both specimens were retrieved at three, six, 12, 24, and 48 months. Undecalcified sections were prepared for ...
  17. Effect of glucose availability on functional membrane integrity, ultrastructure and contractile performance following hypoxia and reoxygenation in isolated feline cardiac muscle

    Journal of Molecular and Cellular Cardiology 12(1):109 (1980)

    Isolated, isometrically contracting feline papillary muscles were used to evaluate the effects of glucose availability during hypoxia and reoxygenation on interrelationships between changes in ultrastructure, contractile parameters and functional membrane integrity tested by an ionic lantha...
  18. Calcium containing lysosomes in the normal chick duodenum: A histochemical and analytical electron microscopic study

    Tissue and Cell 11(1):127 (1979)

    Absorptive cells of the normal chick duodenum contain numerous supranuclear vesicular/vacuolar structures. By routine transmission electron microscopy, such structures are membrane bound and demonstrate a granular content. These vesicles appear to move laterally and eventually coalesce with...