1. Neuropeptide Y regulates the hematopoietic stem cell microenvironment and prevents nerve injury in the bone marrow.

    EMBO Journal 34(12):1648 (2015) PMID 25916827 PMCID PMC4475399

    Many reports have revealed the importance of the sympathetic nervous system (SNS) in the control of the bone marrow environment. However, the specific role of neuropeptide Y (NPY) in this process has not been systematically studied. Here we show that NPY-deficient mice have significantly reduced...
  2. Postprandial metabolism in adults with Prader-Willi syndrome.

    Obesity 23(6):1159 (2015) PMID 25958986

    Individuals with Prader-Willi syndrome (PWS) are commonly restricted to 60-75% of height-appropriate calorie intake because they rapidly become obese on a normal diet. This study measured changes in energy expenditure, glucose and lipid homeostasis, and metabolic flexibility in response to a mea...
  3. NPY signalling in early osteoblasts controls glucose homeostasis.

    Molecular Metabolism 4(3):164 (2015) PMID 25737952 PMCID PMC4338316

    The skeleton has recently emerged as an additional player in the control of whole-body glucose metabolism; however, the mechanism behind this is not clear. Here we employ mice lacking neuropeptide Y, Y1 receptors solely in cells of the early osteoblastic lineage (Y1f3.6Cre), to examine the role ...
  4. Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI.

    PLoS ONE 10(7):e0133362 (2015) PMID 26207898 PMCID PMC4514813

    The TGF-b superfamily cytokine MIC-1/GDF15 circulates in the blood of healthy humans. Its levels rise substantially in cancer and other diseases and this may sometimes lead to development of an anorexia/cachexia syndrome. This is mediated by a direct action of MIC-1/GDF15 on feeding centres in t...
  5. Actions of NPY, and its Y1 and Y2 receptors on pulsatile growth hormone secretion during the fed and fasted state.

    Journal of Neuroscience 34(49):16309 (2014) PMID 25471570

    The hypothalamic NPY system plays an important role in regulating food intake and energy expenditure. Different biological actions of NPY are assigned to NPY receptor subtypes. Recent studies demonstrated a close relationship between food intake and growth hormone (GH) secretion; however, the me...
  6. Actions of NPY, and Its Y1 and Y2 Receptors on Pulsatile Growth Hormone Secretion during the Fed and Fasted State.

    Journal of Neuroscience 34(49):16309 (2014) PMID 25471570

    The hypothalamic NPY system plays an important role in regulating food intake and energy expenditure. Different biological actions of NPY are assigned to NPY receptor subtypes. Recent studies demonstrated a close relationship between food intake and growth hormone (GH) secretion; however, the me...
  7. Actions of NPY, and its Y1 and Y2 receptors on pulsatile growth hormone secretion during the fed and fasted state.

    Journal of Neuroscience 34(49):16309 (2014) PMID 25471570

    The hypothalamic NPY system plays an important role in regulating food intake and energy expenditure. Different biological actions of NPY are assigned to NPY receptor subtypes. Recent studies demonstrated a close relationship between food intake and growth hormone (GH) secretion; however, the me...
  8. Actions of NPY, and Its Y1 and Y2 Receptors on Pulsatile Growth Hormone Secretion during the Fed and Fasted State.

    Journal of Neuroscience 34(49):16309 (2014) PMID 25471570

    The hypothalamic NPY system plays an important role in regulating food intake and energy expenditure. Different biological actions of NPY are assigned to NPY receptor subtypes. Recent studies demonstrated a close relationship between food intake and growth hormone (GH) secretion; however, the me...
  9. Regulation of Energy Homeostasis by the NPY system

    Trends in Endocrinology & Metabolism 26(3) (2014)

    • The NPY system is one of the most important regulators of appetite and energy balance. NPY control feeding but is also critical in the regulation of energy expenditure ...
  10. Macrophage inhibitory cytokine 1 (MIC-1/GDF15), a novel regulator of body weight and appetite and a potential therapeutic for obesity

    Obesity Research & Clinical Practice 8:105 (2014)

  11. NPY signalling in early osteoblasts controls glucose homeostasis

    Molecular Metabolism 4(3) (2014) PMID 25737952 PMCID PMC4338316

    Objective The skeleton has recently emerged as an additional player in the control of whole-body glucose metabolism; however, the mechanism behind this is not clear.
  12. NPY signalling in early osteoblasts controls glucose homeostasis

    Molecular Metabolism 4(3) (2014) PMID 25737952 PMCID PMC4338316

    Objective The skeleton has recently emerged as an additional player in the control of whole-body glucose metabolism; however, the mechanism behind this is not clear.
  13. NPY signalling in early osteoblasts controls glucose homeostasis

    Molecular Metabolism 4(3) (2014) PMID 25737952 PMCID PMC4338316

    Objective The skeleton has recently emerged as an additional player in the control of whole-body glucose metabolism; however, the mechanism behind this is not clear.
  14. NPY signalling in early osteoblasts controls glucose homeostasis

    Molecular Metabolism 4(3) (2014) PMID 25737952 PMCID PMC4338316

    Objective The skeleton has recently emerged as an additional player in the control of whole-body glucose metabolism; however, the mechanism behind this is not clear.
  15. Stress- and diet-induced fat gain is controlled by NPY in catecholaminergic neurons.

    Molecular Metabolism 3(5):581 (2014) PMID 25061562 PMCID PMC4099511

    Neuropeptide Y (NPY) and noradrenaline are commonly co-expressed in sympathetic neurons. Both are key regulators of energy homeostasis and critical for stress-coping. However, little is known about the specific function of NPY in the catecholaminergic system in these regulations. Here we show th...
  16. LOW HIPPOCAMPAL PRODYNORPHIN LEVELS ARE ASSOCIATED WITH MAINTENANCE OF MEMORY IN VARIOUS AGING RODENT MODELS

    Alzheimer's & Dementia 10(4):P269 (2014)

  17. Double deletion of orexigenic neuropeptide Y and dynorphin results in paradoxical obesity in mice.

    Neuropeptides 48(3):143 (2014) PMID 24680736

    Orexigenic neuropeptide Y (NPY) and dynorphin (DYN) regulate energy homeostasis. Single NPY or dynorphin deletion reduces food intake or increases fat loss. Future developments of obesity therapeutics involve targeting multiple pathways. We hypothesised that NPY and dynorphin regulate energy hom...
  18. Double deletion of orexigenic neuropeptide Y and dynorphin results in paradoxical obesity in mice

    Neuropeptides 48(3):143 (2014)

    Objective Orexigenic neuropeptide Y (NPY) and dynorphin (DYN) regulate energy homeostasis. Single NPY or dynorphin deletion reduces food intake or increases fat loss. Future developments of obesity therapeutics involve targeting multiple pathways. We hypothesised that NPY and...
  19. Double deletion of orexigenic neuropeptide Y and dynorphin results in paradoxical obesity in mice.

    Neuropeptides 48(3):143 (2014) PMID 24680736

    Orexigenic neuropeptide Y (NPY) and dynorphin (DYN) regulate energy homeostasis. Single NPY or dynorphin deletion reduces food intake or increases fat loss. Future developments of obesity therapeutics involve targeting multiple pathways. We hypothesised that NPY and dynorphin regulate energy hom...
  20. Synthetic routes to the Neuropeptide Y Y1 receptor antagonist 1229U91 and related analogues for SAR studies and cell-based imaging.

    Organic & Biomolecular Chemistry 12(20):3271 (2014) PMID 24733083

    The potent Y1 receptor antagonist, 1229U91 has an unusual cyclic dimer structure that makes syntheses of analogue series quite challenging. We have examined three new routes to the synthesis of such peptides that has given access to novel structural variants including heterodimeric compounds, ri...