1. Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3.

    Protein Science 18(3):514 (2009) PMID 19241369 PMCID PMC2760358

    SIRT3 is a key mitochondrial protein deacetylase proposed to play key roles in regulating mitochondrial metabolism but there has been considerable debate about its actual size, the sequences required for activity, and its subcellular localization. A previously cloned mouse SIRT3 has high sequenc...
  2. Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3.

    Protein Science 18(3):514 (2009) PMID 19241369 PMCID PMC2760358

    SIRT3 is a key mitochondrial protein deacetylase proposed to play key roles in regulating mitochondrial metabolism but there has been considerable debate about its actual size, the sequences required for activity, and its subcellular localization. A previously cloned mouse SIRT3 has high sequenc...
  3. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.

    Nature 450(7170):712 (2007) PMID 18046409 PMCID PMC2753457

    Calorie restriction extends lifespan and produces a metabolic profile desirable for treating diseases of ageing such as type 2 diabetes. SIRT1, an NAD+-dependent deacetylase, is a principal modulator of pathways downstream of calorie restriction that produce beneficial effects on glucose homeost...