1. miR-144/451 Promote Cell Proliferation via Targeting PTEN/AKT Pathway in Insulinomas.

    Endocrinology 156(7):2429 (2015) PMID 25919186

    Insulinoma is the main type of functional pancreatic neuroendocrine tumors. The functional microRNAs (miRNAs) regulating tumor growth and progression in insulinomas are still unknown. We conducted the miRNA expression profile analysis using miRNA quantitative RT-PCR array and identified 114 diff...
  2. The HSP90 inhibitor 17-AAG exhibits potent antitumor activity for pheochromocytoma in a xenograft model.

    Tumor Biology 36(7):5103 (2015) PMID 25682284

    This study aims to investigate the effect of heat shock protein 90 (HSP90) inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) in the malignant pheochromocytoma using a xenograft mouse model. Treatment with 17-AAG induced a marked reduction in the volume and weight of PC12 pheochromocytoma...
  3. Analysis of Human Triallelic SNPs by Next-Generation Sequencing.

    Annals of Human Genetics 79(4):275 (2015) PMID 25907303

    Although single-nucleotide polymorphisms (SNPs) have become extremely useful in the study of geneticvariation, triallelic SNPs are still not fully understood. Next-generation sequencing (NGS) is a promising approach to identify triallelic sites in large populations. In this study, we explored ex...
  4. Advanced fibrosis associates with atherosclerosis in subjects with nonalcoholic fatty liver disease.

    Atherosclerosis 241(1):145 (2015) PMID 25988358

    Nonalcoholic fatty liver (NAFLD) with advanced fibrosis usually has a deteriorated prognosis, which was mainly attributed to cardiovascular cause. We investigated whether advanced fibrosis assessed by noninvasive fibrosis markers was associated with subclinical atherosclerosis in NAFLD patients....
  5. Generation and Characterization of Transgenic Mice Expressing Mouse Ins1 Promoter for Pancreatic β-Cell-Specific Gene Overexpression and Knockout.

    Endocrinology 156(7):2724 (2015) PMID 25885930

    The technologies for pancreatic β-cell-specific gene overexpression or knockout are fundamental for investigations of functional genes in vivo. Here we generated the Ins1-Cre-Dsred and Ins1-rtTA mouse models, which expressed the Cre recombinase or reverse tetracycline regulatable transactivator ...
  6. Association between metabolic syndrome and lung function in middle-aged and elderly Chinese individuals.

    Diabetes Research and Clinical Practice 108(3):e46 (2015) PMID 25818886

    Subjects with metabolic syndrome (MetS) had lower FVC and FEV1 than non-MetS subjects and decreased gradually with the increasing number of MetS components. After adjusting for potential risk factors, the lowest quartile of FVC and FEV1 was associated with increased risk of MetS. Copyright © 20...
  7. Dietary Fat Intake Modifies the Effect of a Common Variant in the LIPC Gene on Changes in Serum Lipid Concentrations during a Long-Term Weight-Loss Intervention Trial.

    Journal of Nutrition 145(6):1289 (2015) PMID 25926410 PMCID PMC4442119

    Hepatic lipase (HL) plays a pivotal role in the metabolism of HDL and LDL. Recent genome-wide association studies have identified common variants in the HL gene (LIPC) associated with HDL cholesterol. We tested the effect of a common variant in LIPC on changes in blood lipids in response to weig...
  8. Circulating microRNA predicts insensitivity to glucocorticoid therapy in Graves' ophthalmopathy.

    Endocrine 49(2):445 (2015) PMID 25588771

    Glucocorticoid (GC) insensitivity occurs commonly in Graves' ophthalmopathy (GO), and GC therapy is associated with major adverse effects. A reliable and easily accessible biomarker is required to predict the outcome of GC therapy. This study aimed to evaluate the performance of circulating micr...
  9. Sequential Versus Continual Purified Urinary FSH/hCG in Men With Idiopathic Hypogonadotropic Hypogonadism.

    Journal of Clinical Endocrinology & Metabolism 100(6):2449 (2015) PMID 25825944

    Gonadotropin therapy using a human chorionic gonadotropin (hCG) and FSH preparation is an effective regimen in inducing masculinization and spermatogenesis in men with idiopathic hypogonadotropic hypogonadism (IHH). However, the high cost of medication and frequent injections affect compliance. ...
  10. Afternoon nap and nighttime sleep with risk of micro- and macrovascular disease in middle-aged and elderly population.

    International Journal of Cardiology 187:553 (2015) PMID 25863301

  11. Subclinical hypothyroidism might worsen the effects of aging on serum lipid profiles: a population-based case-control study.

    Thyroid 25(5):485 (2015) PMID 25780934

    Dyslipidemia is an important global health problem, particularly in the elderly population. Traditionally, the high prevalence of dyslipidemia in elderly people is considered a "natural condition." Notably, subclinical hypothyroidism (SCH) is one of the most important risk factors for dyslipidem...
  12. Diagnostic value of ACTH stimulation test in determining the subtypes of primary aldosteronism.

    Journal of Clinical Endocrinology & Metabolism 100(5):1837 (2015) PMID 25695882

    Adrenal venous sampling is recommended as the golden standard for subtyping primary aldosteronism (PA). However, it is invasive and inconvenient, and seeking a better way to make differential diagnosis of PA is necessary. The objective of the study was to evaluate the diagnostic value of ACTH st...
  13. Serum lipoprotein (a) concentrations are inversely associated with T2D, prediabetes, and insulin resistance in a middle-aged and elderly Chinese population.

    Journal of Lipid Research 56(4):920 (2015) PMID 25649924 PMCID PMC4373748

    Lipoprotein (a) [Lp(a)], an LDL-like particle, has been proposed as a causal risk factor for CVD among general populations. Meanwhile, both serum Lp(a) and diabetes increase the risk of CVD. However, the relationship between serum Lp(a) and T2D is poorly characterized, especially in the Asian po...
  14. High levels of chorionic gonadotrophin attenuate insulin sensitivity and promote inflammation in adipocytes.

    Journal of Molecular Endocrinology 54(2):161 (2015) PMID 25691497

    Gestational diabetes mellitus (GDM) presents with moderate inflammation, insulin resistance and impaired glucose uptake, which may result from increased maternal fat mass and increased circulation of placental hormones and adipokines. In this study, we set out to test whether the surge in chorio...
  15. Status of cardiovascular health in chinese adults.

    Journal of the American College of Cardiology 65(10):1013 (2015) PMID 25766949

    Cardiovascular disease has become the leading cause of death in China. The goal of this study was to evaluate the current status of cardiovascular health in Chinese adults. Cardiovascular health data were collected from a nationally representative sample of 96,121 Chinese adults age ≥20 years in...
  16. Status of Cardiovascular Health in Chinese Adults

    Journal of the American College of Cardiology 65(10):1013 (2015)

    Background Cardiovascular disease has become the leading cause of death in China.
  17. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.

    Human Molecular Genetics 24(6):1791 (2015) PMID 25429064 PMCID PMC4351379

    Human height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A rec...
  18. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.

    Human Molecular Genetics 24(6):1791 (2015) PMID 25429064 PMCID PMC4351379

    Human height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A rec...
  19. Coronary artery bypass grafting versus drug-eluting stents in patients with severe coronary artery disease and diabetes mellitus: systematic review and meta-analysis.

    Journal Of Diabetes 7(2):192 (2015) PMID 24893748

    A comprehensive meta-analysis was performed to evaluate the comparative benefits of coronary artery bypass grafting (CABG) versus drug-eluting stents (DES) in patients with diabetes mellitus and severe coronary artery disease (CAD). A comprehensive literature search of PubMed, Embase, and Scienc...
  20. Decreased miR-146 expression in peripheral blood mononuclear cells is correlated with ongoing islet autoimmunity in type 1 diabetes patients 1miR-146.

    Journal Of Diabetes 7(2):158 (2015) PMID 24796653

    Type 1 diabetes mellitus (T1D) is a common autoimmune disease mediated by autoimmune attack against pancreatic β-cells. It has been reported that dysregulation of microRNAs (miRNAs) may contribute to the pathogenesis of autoimmune diseases, including T1D. The aim of the present study was to iden...